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STK10 (serine/threonine kinase 10)

Identity

Other namesLOK
PRO2729
HGNC (Hugo) STK10
LocusID (NCBI) 6793
Location 5q35.1
Location_base_pair Starts at 171469074 and ends at 171615346 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK10   11388
Cards
Entrez_Gene (NCBI)STK10  6793  serine/threonine kinase 10
GeneCards (Weizmann)STK10
Ensembl (Hinxton)ENSG00000072786 [Gene_View]  chr5:171469074-171615346 [Contig_View]  STK10 [Vega]
ICGC DataPortalENSG00000072786
cBioPortalSTK10
AceView (NCBI)STK10
Genatlas (Paris)STK10
WikiGenes6793
SOURCE (Princeton)NM_005990
Genomic and cartography
GoldenPath (UCSC)STK10  -  5q35.1   chr5:171469074-171615346 -  5q35.1   [Description]    (hg19-Feb_2009)
EnsemblSTK10 - 5q35.1 [CytoView]
Mapping of homologs : NCBISTK10 [Mapview]
OMIM603919   
Gene and transcription
Genbank (Entrez)AB015718 AF119894 AI584023 AK022960 AK092814
RefSeq transcript (Entrez)NM_005990
RefSeq genomic (Entrez)AC_000137 NC_000005 NC_018916 NT_023133 NW_001838954 NW_004929325
Consensus coding sequences : CCDS (NCBI)STK10
Cluster EST : UnigeneHs.744005 [ NCBI ]
CGAP (NCI)Hs.744005
Alternative Splicing : Fast-db (Paris)GSHG0025258
Alternative Splicing GalleryENSG00000072786
Gene ExpressionSTK10 [ NCBI-GEO ]     STK10 [ SEEK ]   STK10 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94804 (Uniprot)
NextProtO94804  [Medical]
With graphics : InterProO94804
Splice isoforms : SwissVarO94804 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   PKK [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrO94804
Domain families : Pfam (Sanger)Pkinase (PF00069)    PKK (PF12474)   
Domain families : Pfam (NCBI)pfam00069    pfam12474   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations6793
Blocks (Seattle)O94804
PDB (SRS)2J7T    4AOT    4BC6    4EQU   
PDB (PDBSum)2J7T    4AOT    4BC6    4EQU   
PDB (IMB)2J7T    4AOT    4BC6    4EQU   
PDB (RSDB)2J7T    4AOT    4BC6    4EQU   
Human Protein AtlasENSG00000072786 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO94804
HPRD06796
IPIIPI00304742   IPI00383311   IPI00984626   
Protein Interaction databases
DIP (DOE-UCLA)O94804
IntAct (EBI)O94804
FunCoupENSG00000072786
BioGRIDSTK10
InParanoidO94804
Interologous Interaction database O94804
IntegromeDBSTK10
STRING (EMBL)STK10
Ontologies - Pathways
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  cell cycle  polo kinase kinase activity  identical protein binding  protein homodimerization activity  protein autophosphorylation  lymphocyte aggregation  regulation of lymphocyte migration  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  cell cycle  polo kinase kinase activity  identical protein binding  protein homodimerization activity  protein autophosphorylation  lymphocyte aggregation  regulation of lymphocyte migration  
Protein Interaction DatabaseSTK10
Wikipedia pathwaysSTK10
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STK10
snp3D : Map Gene to Disease6793
SNP (GeneSNP Utah)STK10
SNP : HGBaseSTK10
Genetic variants : HAPMAPSTK10
Exome VariantSTK10
1000_GenomesSTK10 
ICGC programENSG00000072786 
Somatic Mutations in Cancer : COSMICSTK10 
CONAN: Copy Number AnalysisSTK10 
Mutations and Diseases : HGMDSTK10
Genomic VariantsSTK10  STK10 [DGVbeta]
dbVarSTK10
ClinVarSTK10
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603919   
MedgenSTK10
GENETestsSTK10
Disease Genetic AssociationSTK10
Huge Navigator STK10 [HugePedia]  STK10 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneSTK10
Homology/Alignments : Family Browser (UCSC)STK10
Phylogenetic Trees/Animal Genes : TreeFamSTK10
Chemical/Protein Interactions : CTD6793
Chemical/Pharm GKB GenePA36197
Clinical trialSTK10
Cancer Resource (Charite)ENSG00000072786
Other databases
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
CoreMineSTK10
iHOPSTK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:21:32 CEST 2014

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