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STK10 (serine/threonine kinase 10)

Identity

Other namesLOK
PRO2729
HGNC (Hugo) STK10
LocusID (NCBI) 6793
Atlas_Id 43506
Location 5q35.1
Location_base_pair Starts at 171469074 and ends at 171615346 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP9B (18q23) / STK10 (5q35.1)BMPR2 (2q33.1) / STK10 (5q35.1)C17orf49 (17p13.1) / STK10 (5q35.1)
CD99L2 (Xq28) / STK10 (5q35.1)DNAAF1 (16q23.3) / STK10 (5q35.1)NBPF14 (1q21.2) / STK10 (5q35.1)
SGMS1 (10q11.23) / STK10 (5q35.1)SIL1 (5q31.2) / STK10 (5q35.1)STK10 (5q35.1) / RACK1 (5q35.3)
STK10 (5q35.1) / SH3PXD2B (5q35.1)STK10 (5q35.1) / STK10 (5q35.1)SIL1 5q31.2 / STK10 5q35.1
STK10 5q35.1 / SH3PXD2B 5q35.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)STK10   11388
Cards
Entrez_Gene (NCBI)STK10  6793  serine/threonine kinase 10
GeneCards (Weizmann)STK10
Ensembl hg19 (Hinxton)ENSG00000072786 [Gene_View]  chr5:171469074-171615346 [Contig_View]  STK10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000072786 [Gene_View]  chr5:171469074-171615346 [Contig_View]  STK10 [Vega]
ICGC DataPortalENSG00000072786
TCGA cBioPortalSTK10
AceView (NCBI)STK10
Genatlas (Paris)STK10
WikiGenes6793
SOURCE (Princeton)STK10
Genomic and cartography
GoldenPath hg19 (UCSC)STK10  -     chr5:171469074-171615346 -  5q35.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STK10  -     5q35.1   [Description]    (hg38-Dec_2013)
EnsemblSTK10 - 5q35.1 [CytoView hg19]  STK10 - 5q35.1 [CytoView hg38]
Mapping of homologs : NCBISTK10 [Mapview hg19]  STK10 [Mapview hg38]
OMIM603919   
Gene and transcription
Genbank (Entrez)AB015718 AF119894 AI584023 AK022960 AK092814
RefSeq transcript (Entrez)NM_005990
RefSeq genomic (Entrez)NC_000005 NC_018916 NT_023133 NW_004929325
Consensus coding sequences : CCDS (NCBI)STK10
Cluster EST : UnigeneHs.744005 [ NCBI ]
CGAP (NCI)Hs.744005
Alternative Splicing GalleryENSG00000072786
Gene ExpressionSTK10 [ NCBI-GEO ]   STK10 [ EBI - ARRAY_EXPRESS ]   STK10 [ SEEK ]   STK10 [ MEM ]
Gene Expression Viewer (FireBrowse)STK10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6793
GTEX Portal (Tissue expression)STK10
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94804 (Uniprot)
NextProtO94804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94804
Splice isoforms : SwissVarO94804 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO94804
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PKK    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    PKK (PF12474)   
Domain families : Pfam (NCBI)pfam00069    pfam12474   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations6793
Blocks (Seattle)STK10
PDB (SRS)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
PDB (PDBSum)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
PDB (IMB)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
PDB (RSDB)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
Structural Biology KnowledgeBase2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
SCOP (Structural Classification of Proteins)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
CATH (Classification of proteins structures)2J7T    4AOT    4BC6    4EQU    4USD    4USE    5AJQ   
SuperfamilyO94804
Human Protein AtlasENSG00000072786
Peptide AtlasO94804
HPRD06796
IPIIPI00304742   IPI00383311   IPI00984626   
Protein Interaction databases
DIP (DOE-UCLA)O94804
IntAct (EBI)O94804
FunCoupENSG00000072786
BioGRIDSTK10
STRING (EMBL)STK10
ZODIACSTK10
Ontologies - Pathways
QuickGOO94804
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cell cycle  signal transduction by protein phosphorylation  polo kinase kinase activity  identical protein binding  protein homodimerization activity  protein autophosphorylation  extracellular exosome  lymphocyte aggregation  regulation of lymphocyte migration  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  plasma membrane  protein phosphorylation  cell cycle  signal transduction by protein phosphorylation  polo kinase kinase activity  identical protein binding  protein homodimerization activity  protein autophosphorylation  extracellular exosome  lymphocyte aggregation  regulation of lymphocyte migration  
NDEx Network
Atlas of Cancer Signalling NetworkSTK10
Wikipedia pathwaysSTK10
Orthology - Evolution
OrthoDB6793
GeneTree (enSembl)ENSG00000072786
Phylogenetic Trees/Animal Genes : TreeFamSTK10
Homologs : HomoloGeneSTK10
Homology/Alignments : Family Browser (UCSC)STK10
Gene fusions - Rearrangements
Fusion: TCGASIL1 5q31.2 STK10 5q35.1 BRCA
Fusion: TCGASTK10 5q35.1 SH3PXD2B 5q35.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerSTK10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK10
dbVarSTK10
ClinVarSTK10
1000_GenomesSTK10 
Exome Variant ServerSTK10
ExAC (Exome Aggregation Consortium)STK10 (select the gene name)
Genetic variants : HAPMAP6793
Genomic Variants (DGV)STK10 [DGVbeta]
Mutations
ICGC Data PortalSTK10 
TCGA Data PortalSTK10 
Broad Tumor PortalSTK10
OASIS PortalSTK10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK10 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch STK10
DgiDB (Drug Gene Interaction Database)STK10
DoCM (Curated mutations)STK10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK10 (select a term)
intoGenSTK10
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)5:171469074-171615346  ENSG00000072786
CONAN: Copy Number AnalysisSTK10 
Mutations and Diseases : HGMDSTK10
OMIM603919   
MedgenSTK10
Genetic Testing Registry STK10
NextProtO94804 [Medical]
TSGene6793
GENETestsSTK10
Huge Navigator STK10 [HugePedia]
snp3D : Map Gene to Disease6793
BioCentury BCIQSTK10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6793
Chemical/Pharm GKB GenePA36197
Clinical trialSTK10
Miscellaneous
canSAR (ICR)STK10 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK10
EVEXSTK10
GoPubMedSTK10
iHOPSTK10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun May 8 19:07:41 CEST 2016

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