Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STK16 (serine/threonine kinase 16)

Identity

Alias_symbol (synonym)PKL12
MPSK
Other aliasKRCT
PSK
TSF1
hPSK
HGNC (Hugo) STK16
LocusID (NCBI) 8576
Atlas_Id 43507
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219245479 and ends at 219250337 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POMC (2p23.3) / STK16 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK16   11394
Cards
Entrez_Gene (NCBI)STK16  8576  serine/threonine kinase 16
AliasesKRCT; MPSK; PKL12; PSK; 
TSF1; hPSK
GeneCards (Weizmann)STK16
Ensembl hg19 (Hinxton)ENSG00000115661 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115661 [Gene_View]  ENSG00000115661 [Sequence]  chr2:219245479-219250337 [Contig_View]  STK16 [Vega]
ICGC DataPortalENSG00000115661
TCGA cBioPortalSTK16
AceView (NCBI)STK16
Genatlas (Paris)STK16
WikiGenes8576
SOURCE (Princeton)STK16
Genetics Home Reference (NIH)STK16
Genomic and cartography
GoldenPath hg38 (UCSC)STK16  -     chr2:219245479-219250337 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK16  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathSTK16 - 2q35 [CytoView hg19]  STK16 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000115661
Mapping of homologs : NCBISTK16 [Mapview hg19]  STK16 [Mapview hg38]
OMIM604719   
Gene and transcription
Genbank (Entrez)AA741170 AB020739 AF060798 AF203910 AJ005791
RefSeq transcript (Entrez)NM_001008910 NM_001330213 NM_001330214 NM_001330215 NM_003691 NM_032768
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK16
Alternative Splicing GalleryENSG00000115661
Gene ExpressionSTK16 [ NCBI-GEO ]   STK16 [ EBI - ARRAY_EXPRESS ]   STK16 [ SEEK ]   STK16 [ MEM ]
Gene Expression Viewer (FireBrowse)STK16 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8576
GTEX Portal (Tissue expression)STK16
Human Protein AtlasENSG00000115661-STK16 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75716   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75716  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75716
Splice isoforms : SwissVarO75716
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO75716
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK16
DMDM Disease mutations8576
Blocks (Seattle)STK16
PDB (RSDB)2BUJ   
PDB Europe2BUJ   
PDB (PDBSum)2BUJ   
PDB (IMB)2BUJ   
Structural Biology KnowledgeBase2BUJ   
SCOP (Structural Classification of Proteins)2BUJ   
CATH (Classification of proteins structures)2BUJ   
SuperfamilyO75716
Human Protein Atlas [tissue]ENSG00000115661-STK16 [tissue]
Peptide AtlasO75716
HPRD05281
IPIIPI00306833   IPI00909976   IPI00915837   IPI00916226   
Protein Interaction databases
DIP (DOE-UCLA)O75716
IntAct (EBI)O75716
FunCoupENSG00000115661
BioGRIDSTK16
STRING (EMBL)STK16
ZODIACSTK16
Ontologies - Pathways
QuickGOO75716
Ontology : AmiGORNA polymerase II proximal promoter sequence-specific DNA binding  protein serine/threonine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi-associated vesicle  cytosol  membrane  peptidyl-tyrosine phosphorylation  positive regulation of transcription by RNA polymerase II  protein autophosphorylation  perinuclear region of cytoplasm  cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBIRNA polymerase II proximal promoter sequence-specific DNA binding  protein serine/threonine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  Golgi-associated vesicle  cytosol  membrane  peptidyl-tyrosine phosphorylation  positive regulation of transcription by RNA polymerase II  protein autophosphorylation  perinuclear region of cytoplasm  cellular response to transforming growth factor beta stimulus  
NDEx NetworkSTK16
Atlas of Cancer Signalling NetworkSTK16
Wikipedia pathwaysSTK16
Orthology - Evolution
OrthoDB8576
GeneTree (enSembl)ENSG00000115661
Phylogenetic Trees/Animal Genes : TreeFamSTK16
HOGENOMO75716
Homologs : HomoloGeneSTK16
Homology/Alignments : Family Browser (UCSC)STK16
Gene fusions - Rearrangements
Fusion : QuiverSTK16
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK16 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK16
dbVarSTK16
ClinVarSTK16
1000_GenomesSTK16 
Exome Variant ServerSTK16
ExAC (Exome Aggregation Consortium)ENSG00000115661
GNOMAD BrowserENSG00000115661
Varsome BrowserSTK16
Genetic variants : HAPMAP8576
Genomic Variants (DGV)STK16 [DGVbeta]
DECIPHERSTK16 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK16 
Mutations
ICGC Data PortalSTK16 
TCGA Data PortalSTK16 
Broad Tumor PortalSTK16
OASIS PortalSTK16 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK16  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTK16
Mutations and Diseases : HGMDSTK16
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK16
DgiDB (Drug Gene Interaction Database)STK16
DoCM (Curated mutations)STK16 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK16 (select a term)
intoGenSTK16
Cancer3DSTK16(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604719   
Orphanet
DisGeNETSTK16
MedgenSTK16
Genetic Testing Registry STK16
NextProtO75716 [Medical]
TSGene8576
GENETestsSTK16
Target ValidationSTK16
Huge Navigator STK16 [HugePedia]
snp3D : Map Gene to Disease8576
BioCentury BCIQSTK16
ClinGenSTK16
Clinical trials, drugs, therapy
Protein Interactions : CTD8576
Pharm GKB GenePA36202
Clinical trialSTK16
Miscellaneous
canSAR (ICR)STK16 (select the gene name)
HarmonizomeSTK16
DataMed IndexSTK16
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK16
EVEXSTK16
GoPubMedSTK16
iHOPSTK16
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:32:46 CEST 2020
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