Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STK17A (serine/threonine kinase 17a)

Identity

Alias_namesserine/threonine kinase 17a (apoptosis-inducing)
Alias_symbol (synonym)DRAK1
Other alias
HGNC (Hugo) STK17A
LocusID (NCBI) 9263
Atlas_Id 42437
Location 7p13  [Link to chromosome band 7p13]
Location_base_pair Starts at 43583108 and ends at 43627379 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
STK17A (7p13) / GET4 (7p22.3)STK17A (7p13) / STK17A (7p13)STK17A (7p13) / TMEM123 (11q22.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK17A   11395
Cards
Entrez_Gene (NCBI)STK17A  9263  serine/threonine kinase 17a
AliasesDRAK1
GeneCards (Weizmann)STK17A
Ensembl hg19 (Hinxton)ENSG00000164543 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164543 [Gene_View]  ENSG00000164543 [Sequence]  chr7:43583108-43627379 [Contig_View]  STK17A [Vega]
ICGC DataPortalENSG00000164543
TCGA cBioPortalSTK17A
AceView (NCBI)STK17A
Genatlas (Paris)STK17A
WikiGenes9263
SOURCE (Princeton)STK17A
Genetics Home Reference (NIH)STK17A
Genomic and cartography
GoldenPath hg38 (UCSC)STK17A  -     chr7:43583108-43627379 +  7p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK17A  -     7p13   [Description]    (hg19-Feb_2009)
GoldenPathSTK17A - 7p13 [CytoView hg19]  STK17A - 7p13 [CytoView hg38]
ImmunoBaseENSG00000164543
Mapping of homologs : NCBISTK17A [Mapview hg19]  STK17A [Mapview hg38]
OMIM604726   
Gene and transcription
Genbank (Entrez)AB011420 AK097170 AW183478 BC023508 BC047696
RefSeq transcript (Entrez)NM_004760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK17A
Alternative Splicing GalleryENSG00000164543
Gene ExpressionSTK17A [ NCBI-GEO ]   STK17A [ EBI - ARRAY_EXPRESS ]   STK17A [ SEEK ]   STK17A [ MEM ]
Gene Expression Viewer (FireBrowse)STK17A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9263
GTEX Portal (Tissue expression)STK17A
Human Protein AtlasENSG00000164543-STK17A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UEE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UEE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UEE5
Splice isoforms : SwissVarQ9UEE5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UEE5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DRAK1_STKc    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK17A
DMDM Disease mutations9263
Blocks (Seattle)STK17A
SuperfamilyQ9UEE5
Human Protein Atlas [tissue]ENSG00000164543-STK17A [tissue]
Peptide AtlasQ9UEE5
HPRD05288
IPIIPI00646659   IPI00386205   
Protein Interaction databases
DIP (DOE-UCLA)Q9UEE5
IntAct (EBI)Q9UEE5
FunCoupENSG00000164543
BioGRIDSTK17A
STRING (EMBL)STK17A
ZODIACSTK17A
Ontologies - Pathways
QuickGOQ9UEE5
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  nucleus  plasma membrane  protein phosphorylation  apoptotic process  nuclear speck  intracellular signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of fibroblast apoptotic process  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  nucleus  nucleus  plasma membrane  protein phosphorylation  apoptotic process  nuclear speck  intracellular signal transduction  intracellular signal transduction  positive regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of fibroblast apoptotic process  regulation of reactive oxygen species metabolic process  
NDEx NetworkSTK17A
Atlas of Cancer Signalling NetworkSTK17A
Wikipedia pathwaysSTK17A
Orthology - Evolution
OrthoDB9263
GeneTree (enSembl)ENSG00000164543
Phylogenetic Trees/Animal Genes : TreeFamSTK17A
HOGENOMQ9UEE5
Homologs : HomoloGeneSTK17A
Homology/Alignments : Family Browser (UCSC)STK17A
Gene fusions - Rearrangements
Fusion : QuiverSTK17A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK17A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK17A
dbVarSTK17A
ClinVarSTK17A
1000_GenomesSTK17A 
Exome Variant ServerSTK17A
ExAC (Exome Aggregation Consortium)ENSG00000164543
GNOMAD BrowserENSG00000164543
Varsome BrowserSTK17A
Genetic variants : HAPMAP9263
Genomic Variants (DGV)STK17A [DGVbeta]
DECIPHERSTK17A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK17A 
Mutations
ICGC Data PortalSTK17A 
TCGA Data PortalSTK17A 
Broad Tumor PortalSTK17A
OASIS PortalSTK17A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK17A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTK17A
Mutations and Diseases : HGMDSTK17A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK17A
DgiDB (Drug Gene Interaction Database)STK17A
DoCM (Curated mutations)STK17A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK17A (select a term)
intoGenSTK17A
Cancer3DSTK17A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604726   
Orphanet
DisGeNETSTK17A
MedgenSTK17A
Genetic Testing Registry STK17A
NextProtQ9UEE5 [Medical]
TSGene9263
GENETestsSTK17A
Target ValidationSTK17A
Huge Navigator STK17A [HugePedia]
snp3D : Map Gene to Disease9263
BioCentury BCIQSTK17A
ClinGenSTK17A
Clinical trials, drugs, therapy
Protein Interactions : CTD9263
Pharm GKB GenePA36203
Clinical trialSTK17A
Miscellaneous
canSAR (ICR)STK17A (select the gene name)
HarmonizomeSTK17A
DataMed IndexSTK17A
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK17A
EVEXSTK17A
GoPubMedSTK17A
iHOPSTK17A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Jun 30 20:32:46 CEST 2020
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