STK17A (serine/threonine kinase 17a)

2003-11-01  

Identity

HGNC
STK17A
LOCATION
7p13
LOCUSID
9263
ALIAS
DRAK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9263
MIM: 604726
HGNC: 11395
Ensembl: ENSG00000164543

Variants:

dbSNP: 9263
ClinVar: 9263
TCGA: ENSG00000164543
COSMIC: STK17A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164543ENST00000319357Q9UEE5
ENSG00000164543ENST00000648544Q9UEE5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
214899892011Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells.11
255313292015Cytoplasmic DRAK1 overexpressed in head and neck cancers inhibits TGF-β1 tumor suppressor activity by binding to Smad3 to interrupt its complex formation with Smad4.9
238603222013Polymorphisms in STK17A gene are associated with systemic lupus erythematosus and its clinical manifestations.8
243123602013Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma.7
263050962015Abnormal Localization of STK17A in Bile Canaliculi in Liver Allografts: An Early Sign of Chronic Rejection.3
293979382018Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1.2
305305032019Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling.2
306553192019Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells.2

Citation

Dessen P

STK17A (serine/threonine kinase 17a)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42437/stk17a