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STK17B (serine/threonine kinase 17b)

Identity

Alias_namesserine/threonine kinase 17b (apoptosis-inducing)
Alias_symbol (synonym)DRAK2
Other alias
HGNC (Hugo) STK17B
LocusID (NCBI) 9262
Atlas_Id 42438
Location 2q32.3  [Link to chromosome band 2q32]
Location_base_pair Starts at 196133583 and ends at 196171612 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CD68 (17p13.1) / STK17B (2q32.3)STK17B (2q32.3) / CUX1 (7q22.1)STK17B (2q32.3) / HECW2 (2q32.3)
STK17B (2q32.3) / SLC4A2 (7q36.1)TRIM33 (1p13.2) / STK17B (2q32.3)STK17B 2q32.3 / HECW2 2q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(q32;q33) STK17B/HECW2

External links

Nomenclature
HGNC (Hugo)STK17B   11396
Cards
Entrez_Gene (NCBI)STK17B  9262  serine/threonine kinase 17b
AliasesDRAK2
GeneCards (Weizmann)STK17B
Ensembl hg19 (Hinxton)ENSG00000081320 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000081320 [Gene_View]  ENSG00000081320 [Sequence]  chr2:196133583-196171612 [Contig_View]  STK17B [Vega]
ICGC DataPortalENSG00000081320
TCGA cBioPortalSTK17B
AceView (NCBI)STK17B
Genatlas (Paris)STK17B
WikiGenes9262
SOURCE (Princeton)STK17B
Genetics Home Reference (NIH)STK17B
Genomic and cartography
GoldenPath hg38 (UCSC)STK17B  -     chr2:196133583-196171612 -  2q32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK17B  -     2q32.3   [Description]    (hg19-Feb_2009)
EnsemblSTK17B - 2q32.3 [CytoView hg19]  STK17B - 2q32.3 [CytoView hg38]
Mapping of homologs : NCBISTK17B [Mapview hg19]  STK17B [Mapview hg38]
OMIM604727   
Gene and transcription
Genbank (Entrez)AB011421 AK312865 BC016040 BC052561 BM994696
RefSeq transcript (Entrez)NM_004226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK17B
Cluster EST : UnigeneHs.88297 [ NCBI ]
CGAP (NCI)Hs.88297
Alternative Splicing GalleryENSG00000081320
Gene ExpressionSTK17B [ NCBI-GEO ]   STK17B [ EBI - ARRAY_EXPRESS ]   STK17B [ SEEK ]   STK17B [ MEM ]
Gene Expression Viewer (FireBrowse)STK17B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9262
GTEX Portal (Tissue expression)STK17B
Human Protein AtlasENSG00000081320-STK17B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94768   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94768  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94768
Splice isoforms : SwissVarO94768
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO94768
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK17B
DMDM Disease mutations9262
Blocks (Seattle)STK17B
PDB (SRS)3LM0    3LM5   
PDB (PDBSum)3LM0    3LM5   
PDB (IMB)3LM0    3LM5   
PDB (RSDB)3LM0    3LM5   
Structural Biology KnowledgeBase3LM0    3LM5   
SCOP (Structural Classification of Proteins)3LM0    3LM5   
CATH (Classification of proteins structures)3LM0    3LM5   
SuperfamilyO94768
Human Protein Atlas [tissue]ENSG00000081320-STK17B [tissue]
Peptide AtlasO94768
HPRD05289
IPIIPI00014934   IPI00916930   IPI00927329   
Protein Interaction databases
DIP (DOE-UCLA)O94768
IntAct (EBI)O94768
FunCoupENSG00000081320
BioGRIDSTK17B
STRING (EMBL)STK17B
ZODIACSTK17B
Ontologies - Pathways
QuickGOO94768
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  ATP binding  nucleus  nucleus  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  protein phosphorylation  apoptotic process  actin cytoskeleton  intracellular signal transduction  protein autophosphorylation  positive regulation of fibroblast apoptotic process  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  ATP binding  ATP binding  nucleus  nucleus  endoplasmic reticulum-Golgi intermediate compartment  plasma membrane  protein phosphorylation  apoptotic process  actin cytoskeleton  intracellular signal transduction  protein autophosphorylation  positive regulation of fibroblast apoptotic process  
NDEx NetworkSTK17B
Atlas of Cancer Signalling NetworkSTK17B
Wikipedia pathwaysSTK17B
Orthology - Evolution
OrthoDB9262
GeneTree (enSembl)ENSG00000081320
Phylogenetic Trees/Animal Genes : TreeFamSTK17B
HOVERGENO94768
HOGENOMO94768
Homologs : HomoloGeneSTK17B
Homology/Alignments : Family Browser (UCSC)STK17B
Gene fusions - Rearrangements
Fusion : MitelmanSTK17B/HECW2 [2q32.3/2q32.3]  
Fusion PortalSTK17B 2q32.3 HECW2 2q32.3 BRCA
Fusion : QuiverSTK17B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK17B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK17B
dbVarSTK17B
ClinVarSTK17B
1000_GenomesSTK17B 
Exome Variant ServerSTK17B
ExAC (Exome Aggregation Consortium)ENSG00000081320
GNOMAD BrowserENSG00000081320
Varsome BrowserSTK17B
Genetic variants : HAPMAP9262
Genomic Variants (DGV)STK17B [DGVbeta]
DECIPHERSTK17B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK17B 
Mutations
ICGC Data PortalSTK17B 
TCGA Data PortalSTK17B 
Broad Tumor PortalSTK17B
OASIS PortalSTK17B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK17B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK17B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK17B
DgiDB (Drug Gene Interaction Database)STK17B
DoCM (Curated mutations)STK17B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK17B (select a term)
intoGenSTK17B
Cancer3DSTK17B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604727   
Orphanet
DisGeNETSTK17B
MedgenSTK17B
Genetic Testing Registry STK17B
NextProtO94768 [Medical]
TSGene9262
GENETestsSTK17B
Target ValidationSTK17B
Huge Navigator STK17B [HugePedia]
snp3D : Map Gene to Disease9262
BioCentury BCIQSTK17B
ClinGenSTK17B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9262
Chemical/Pharm GKB GenePA36204
Clinical trialSTK17B
Miscellaneous
canSAR (ICR)STK17B (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK17B
EVEXSTK17B
GoPubMedSTK17B
iHOPSTK17B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:42:36 CET 2018
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