STK17B (serine/threonine kinase 17b)

2003-11-01  

Identity

HGNC
LOCATION
2q32.3
LOCUSID
ALIAS
DRAK2
FUSION GENES

Other Information

Locus ID:

NCBI: 9262
MIM: 604727
HGNC: 11396
Ensembl: ENSG00000081320

Variants:

dbSNP: 9262
ClinVar: 9262
TCGA: ENSG00000081320
COSMIC: STK17B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081320ENST00000263955O94768
ENSG00000081320ENST00000263955Q53QE7
ENSG00000081320ENST00000409228O94768
ENSG00000081320ENST00000409228Q53QE7
ENSG00000081320ENST00000420683C9JZJ1
ENSG00000081320ENST00000606789U3KQF8

Expression (GTEx)

0
10
20
30
40
50
60

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
196389872009Regulation of the apoptosis-inducing kinase DRAK2 by cyclooxygenase-2 in colorectal cancer.11
231229562012DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.10
171826162007Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes.8
195424402009Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development.8
294451892018STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.7
211487962011Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.5
233989432013The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.5
240863682013An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.3

Citation

Dessen P

STK17B (serine/threonine kinase 17b)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42438/stk17b