Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STK24 (serine/threonine kinase 24)

Identity

Alias_namesserine/threonine kinase 24 (Ste20
Alias_symbol (synonym)MST-3
MST3
MST3B
STK3
STE20
Other aliasHEL-S-95
HGNC (Hugo) STK24
LocusID (NCBI) 8428
Atlas_Id 43509
Location 13q32.2  [Link to chromosome band 13q32]
Location_base_pair Starts at 98450199 and ends at 98522125 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL4A2 (13q34) / STK24 (13q32.2)DOCK9 (13q32.3) / STK24 (13q32.2)FARP1 (13q32.2) / STK24 (13q32.2)
MCF2L (13q34) / STK24 (13q32.2)RBBP8 (18q11.2) / STK24 (13q32.2)RPN2 (20q11.23) / STK24 (13q32.2)
STK24 (13q32.2) / ATF7 (12q13.13)STK24 (13q32.2) / KDM4B (19p13.3)STK24 (13q32.2) / PIP5K1B (9q21.11)
STK24 (13q32.2) / RNF4 (4p16.3)STK24 (13q32.2) / TMTC4 (13q32.3)STK24 (13q32.2) / TRIQK (8q22.1)
MCF2L 13q34 / STK24 13q32.2STK24 13q32.2 / ATF7 12q13.13STK24 13q32.2 C8orf83
STK24 13q32.2 / PIP5K1B 9q21.11STK24 13q32.2 / TMTC4 13q32.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(8;13)(q22;q32) STK24/TRIQK
t(9;13)(q21;q32) STK24/PIP5K1B
t(12;13)(q13;q32) STK24/ATF7
t(13;13)(q32;q32) STK24/TMTC4
t(13;13)(q32;q34) MCF2L/STK24

External links

Nomenclature
HGNC (Hugo)STK24   11403
Cards
Entrez_Gene (NCBI)STK24  8428  serine/threonine kinase 24
AliasesHEL-S-95; MST3; MST3B; STE20; 
STK3
GeneCards (Weizmann)STK24
Ensembl hg19 (Hinxton)ENSG00000102572 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102572 [Gene_View]  chr13:98450199-98522125 [Contig_View]  STK24 [Vega]
ICGC DataPortalENSG00000102572
TCGA cBioPortalSTK24
AceView (NCBI)STK24
Genatlas (Paris)STK24
WikiGenes8428
SOURCE (Princeton)STK24
Genetics Home Reference (NIH)STK24
Genomic and cartography
GoldenPath hg38 (UCSC)STK24  -     chr13:98450199-98522125 -  13q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK24  -     13q32.2   [Description]    (hg19-Feb_2009)
EnsemblSTK24 - 13q32.2 [CytoView hg19]  STK24 - 13q32.2 [CytoView hg38]
Mapping of homologs : NCBISTK24 [Mapview hg19]  STK24 [Mapview hg38]
OMIM604984   
Gene and transcription
Genbank (Entrez)AF024636 AF083420 AF339826 AK297583 AK299140
RefSeq transcript (Entrez)NM_001032296 NM_001286649 NM_003576
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK24
Cluster EST : UnigeneHs.508514 [ NCBI ]
CGAP (NCI)Hs.508514
Alternative Splicing GalleryENSG00000102572
Gene ExpressionSTK24 [ NCBI-GEO ]   STK24 [ EBI - ARRAY_EXPRESS ]   STK24 [ SEEK ]   STK24 [ MEM ]
Gene Expression Viewer (FireBrowse)STK24 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8428
GTEX Portal (Tissue expression)STK24
Human Protein AtlasENSG00000102572-STK24 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6E0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6E0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6E0
Splice isoforms : SwissVarQ9Y6E0
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9Y6E0
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK24
DMDM Disease mutations8428
Blocks (Seattle)STK24
PDB (SRS)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
PDB (PDBSum)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
PDB (IMB)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
PDB (RSDB)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
Structural Biology KnowledgeBase3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
SCOP (Structural Classification of Proteins)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
CATH (Classification of proteins structures)3A7F    3A7G    3A7H    3A7I    3A7J    3CKW    3CKX    3ZHP    4O27    4QML    4QMM    4QMN    4QMO    4QMP    4QMQ    4QMS    4QMT    4QMU    4QMV    4QMW    4QMX    4QMY    4QMZ    4QNA    4QO9    4U8Z    4W8D    4W8E   
SuperfamilyQ9Y6E0
Human Protein Atlas [tissue]ENSG00000102572-STK24 [tissue]
Peptide AtlasQ9Y6E0
HPRD10385
IPIIPI00002212   IPI00981772   IPI00641189   IPI00909904   IPI00552426   IPI00640104   IPI01009580   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6E0
IntAct (EBI)Q9Y6E0
FunCoupENSG00000102572
BioGRIDSTK24
STRING (EMBL)STK24
ZODIACSTK24
Ontologies - Pathways
QuickGOQ9Y6E0
Ontology : AmiGOMAPK cascade  activation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein phosphorylation  signal transduction  regulation of mitotic cell cycle  MAP kinase kinase kinase kinase activity  intrinsic apoptotic signaling pathway in response to oxidative stress  cellular response to starvation  membrane  negative regulation of cell migration  stress-activated protein kinase signaling cascade  response to hydrogen peroxide  regulation of apoptotic process  cadherin binding  protein autophosphorylation  protein autophosphorylation  metal ion binding  regulation of axon regeneration  neuron projection morphogenesis  extracellular exosome  execution phase of apoptosis  execution phase of apoptosis  
Ontology : EGO-EBIMAPK cascade  activation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein phosphorylation  signal transduction  regulation of mitotic cell cycle  MAP kinase kinase kinase kinase activity  intrinsic apoptotic signaling pathway in response to oxidative stress  cellular response to starvation  membrane  negative regulation of cell migration  stress-activated protein kinase signaling cascade  response to hydrogen peroxide  regulation of apoptotic process  cadherin binding  protein autophosphorylation  protein autophosphorylation  metal ion binding  regulation of axon regeneration  neuron projection morphogenesis  extracellular exosome  execution phase of apoptosis  execution phase of apoptosis  
NDEx NetworkSTK24
Atlas of Cancer Signalling NetworkSTK24
Wikipedia pathwaysSTK24
Orthology - Evolution
OrthoDB8428
GeneTree (enSembl)ENSG00000102572
Phylogenetic Trees/Animal Genes : TreeFamSTK24
HOVERGENQ9Y6E0
HOGENOMQ9Y6E0
Homologs : HomoloGeneSTK24
Homology/Alignments : Family Browser (UCSC)STK24
Gene fusions - Rearrangements
Fusion : MitelmanMCF2L/STK24 [13q34/13q32.2]  [t(13;13)(q32;q34)]  
Fusion : MitelmanSTK24/ATF7 [13q32.2/12q13.13]  [t(12;13)(q13;q32)]  
Fusion : MitelmanSTK24/PIP5K1B [13q32.2/9q21.11]  [t(9;13)(q21;q32)]  
Fusion : MitelmanSTK24/TMTC4 [13q32.2/13q32.3]  [t(13;13)(q32;q32)]  
Fusion : MitelmanSTK24/TRIQK [13q32.2/8q22.1]  [t(8;13)(q22;q32)]  
Fusion: TCGA_MDACCMCF2L 13q34 STK24 13q32.2 BLCA
Fusion: TCGA_MDACCSTK24 13q32.2 ATF7 12q13.13 BRCA
Fusion: TCGA_MDACCSTK24 13q32.2 C8orf83 LUAD
Fusion: TCGA_MDACCSTK24 13q32.2 PIP5K1B 9q21.11 BRCA
Fusion: TCGA_MDACCSTK24 13q32.2 TMTC4 13q32.3 BLCA
Fusion PortalMCF2L 13q34 STK24 13q32.2 BLCA
Fusion PortalSTK24 13q32.2 ATF7 12q13.13 BRCA
Fusion PortalSTK24 13q32.2 C8orf83 LUAD
Fusion PortalSTK24 13q32.2 PIP5K1B 9q21.11 BRCA
Fusion PortalSTK24 13q32.2 TMTC4 13q32.3 BLCA
Fusion : QuiverSTK24
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK24
dbVarSTK24
ClinVarSTK24
1000_GenomesSTK24 
Exome Variant ServerSTK24
ExAC (Exome Aggregation Consortium)ENSG00000102572
GNOMAD BrowserENSG00000102572
Genetic variants : HAPMAP8428
Genomic Variants (DGV)STK24 [DGVbeta]
DECIPHERSTK24 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK24 
Mutations
ICGC Data PortalSTK24 
TCGA Data PortalSTK24 
Broad Tumor PortalSTK24
OASIS PortalSTK24 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK24  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK24
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK24
DgiDB (Drug Gene Interaction Database)STK24
DoCM (Curated mutations)STK24 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK24 (select a term)
intoGenSTK24
Cancer3DSTK24(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604984   
Orphanet
DisGeNETSTK24
MedgenSTK24
Genetic Testing Registry STK24
NextProtQ9Y6E0 [Medical]
TSGene8428
GENETestsSTK24
Target ValidationSTK24
Huge Navigator STK24 [HugePedia]
snp3D : Map Gene to Disease8428
BioCentury BCIQSTK24
ClinGenSTK24
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8428
Chemical/Pharm GKB GenePA36210
Clinical trialSTK24
Miscellaneous
canSAR (ICR)STK24 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK24
EVEXSTK24
GoPubMedSTK24
iHOPSTK24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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