Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STK25 (serine/threonine kinase 25)

Identity

Alias_namesserine/threonine kinase 25 (Ste20
Alias_symbol (synonym)SOK1
YSK1
Other alias
HGNC (Hugo) STK25
LocusID (NCBI) 10494
Atlas_Id 43510
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 241494707 and ends at 241508695 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		NFYC (1p34.2) / STK25 (2q37.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STK25   11404
Cards
Entrez_Gene (NCBI)STK25  10494  serine/threonine kinase 25
AliasesSOK1; YSK1
GeneCards (Weizmann)STK25
Ensembl hg19 (Hinxton)ENSG00000115694 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115694 [Gene_View]  chr2:241494707-241508695 [Contig_View]  STK25 [Vega]
ICGC DataPortalENSG00000115694
TCGA cBioPortalSTK25
AceView (NCBI)STK25
Genatlas (Paris)STK25
WikiGenes10494
SOURCE (Princeton)STK25
Genetics Home Reference (NIH)STK25
Genomic and cartography
GoldenPath hg38 (UCSC)STK25  -     chr2:241494707-241508695 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK25  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblSTK25 - 2q37.3 [CytoView hg19]  STK25 - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBISTK25 [Mapview hg19]  STK25 [Mapview hg38]
OMIM602255   
Gene and transcription
Genbank (Entrez)AK092161 AK125895 AK291808 AK291947 AK297374
RefSeq transcript (Entrez)NM_001271977 NM_001271978 NM_001271979 NM_001271980 NM_001282305 NM_001282306 NM_001282307 NM_001282308 NM_006374
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK25
Cluster EST : UnigeneHs.516807 [ NCBI ]
CGAP (NCI)Hs.516807
Alternative Splicing GalleryENSG00000115694
Gene ExpressionSTK25 [ NCBI-GEO ]   STK25 [ EBI - ARRAY_EXPRESS ]   STK25 [ SEEK ]   STK25 [ MEM ]
Gene Expression Viewer (FireBrowse)STK25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10494
GTEX Portal (Tissue expression)STK25
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00506   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00506  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00506
Splice isoforms : SwissVarO00506
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusO00506
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK25
DMDM Disease mutations10494
Blocks (Seattle)STK25
PDB (SRS)2XIK    3W8H    4NZW   
PDB (PDBSum)2XIK    3W8H    4NZW   
PDB (IMB)2XIK    3W8H    4NZW   
PDB (RSDB)2XIK    3W8H    4NZW   
Structural Biology KnowledgeBase2XIK    3W8H    4NZW   
SCOP (Structural Classification of Proteins)2XIK    3W8H    4NZW   
CATH (Classification of proteins structures)2XIK    3W8H    4NZW   
SuperfamilyO00506
Human Protein AtlasENSG00000115694
Peptide AtlasO00506
HPRD03770
IPIIPI00012093   IPI00893919   IPI00893689   IPI01009312   IPI00893092   IPI00892997   IPI00892960   IPI00892595   IPI00894406   IPI00894210   IPI00893842   IPI00893926   IPI00893536   IPI00893361   IPI00893500   
Protein Interaction databases
DIP (DOE-UCLA)O00506
IntAct (EBI)O00506
FunCoupENSG00000115694
BioGRIDSTK25
STRING (EMBL)STK25
ZODIACSTK25
Ontologies - Pathways
QuickGOO00506
Ontology : AmiGOGolgi membrane  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  protein phosphorylation  response to oxidative stress  establishment or maintenance of cell polarity  signal transduction  signal transduction by protein phosphorylation  positive regulation of stress-activated MAPK cascade  intrinsic apoptotic signaling pathway in response to hydrogen peroxide  response to hydrogen peroxide  protein homodimerization activity  regulation of cell differentiation  protein autophosphorylation  metal ion binding  positive regulation of axonogenesis  Golgi localization  establishment of Golgi localization  extracellular exosome  Golgi reassembly  
Ontology : EGO-EBIGolgi membrane  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  Golgi apparatus  protein phosphorylation  response to oxidative stress  establishment or maintenance of cell polarity  signal transduction  signal transduction by protein phosphorylation  positive regulation of stress-activated MAPK cascade  intrinsic apoptotic signaling pathway in response to hydrogen peroxide  response to hydrogen peroxide  protein homodimerization activity  regulation of cell differentiation  protein autophosphorylation  metal ion binding  positive regulation of axonogenesis  Golgi localization  establishment of Golgi localization  extracellular exosome  Golgi reassembly  
NDEx NetworkSTK25
Atlas of Cancer Signalling NetworkSTK25
Wikipedia pathwaysSTK25
Orthology - Evolution
OrthoDB10494
GeneTree (enSembl)ENSG00000115694
Phylogenetic Trees/Animal Genes : TreeFamSTK25
HOVERGENO00506
HOGENOMO00506
Homologs : HomoloGeneSTK25
Homology/Alignments : Family Browser (UCSC)STK25
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK25
dbVarSTK25
ClinVarSTK25
1000_GenomesSTK25 
Exome Variant ServerSTK25
ExAC (Exome Aggregation Consortium)STK25 (select the gene name)
Genetic variants : HAPMAP10494
Genomic Variants (DGV)STK25 [DGVbeta]
DECIPHERSTK25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK25 
Mutations
ICGC Data PortalSTK25 
TCGA Data PortalSTK25 
Broad Tumor PortalSTK25
OASIS PortalSTK25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK25
DgiDB (Drug Gene Interaction Database)STK25
DoCM (Curated mutations)STK25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK25 (select a term)
intoGenSTK25
Cancer3DSTK25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602255   
Orphanet
MedgenSTK25
Genetic Testing Registry STK25
NextProtO00506 [Medical]
TSGene10494
GENETestsSTK25
Target ValidationSTK25
Huge Navigator STK25 [HugePedia]
snp3D : Map Gene to Disease10494
BioCentury BCIQSTK25
ClinGenSTK25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10494
Chemical/Pharm GKB GenePA36211
Clinical trialSTK25
Miscellaneous
canSAR (ICR)STK25 (select the gene name)
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK25
EVEXSTK25
GoPubMedSTK25
iHOPSTK25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:57:54 CEST 2017
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