STK3 (serine/threonine kinase 3)

2003-11-01  

Identity

HGNC
LOCATION
8q22.2
LOCUSID
ALIAS
KRS1,MST2
FUSION GENES

Other Information

Locus ID:

NCBI: 6788
MIM: 605030
HGNC: 11406
Ensembl: ENSG00000104375

Variants:

dbSNP: 6788
ClinVar: 6788
TCGA: ENSG00000104375
COSMIC: STK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104375ENST00000419617Q13188
ENSG00000104375ENST00000419617A0A384MR07
ENSG00000104375ENST00000424861Q8NBU1
ENSG00000104375ENST00000518165E5RFQ9
ENSG00000104375ENST00000521649E5RIM6
ENSG00000104375ENST00000523601Q13188
ENSG00000104375ENST00000617590A0A087WZ06

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156880062005The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.214
242551782013Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.157
186409762008Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP).155
178896692007RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein.152
156185212004Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.100
210764102010Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.78
175389462007Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma.64
221959632011Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.59
193279962009MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.52
211998772011The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.44

Citation

Dessen P

STK3 (serine/threonine kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42439/stk3