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STK3 (serine/threonine kinase 3)

Identity

Alias_namesserine/threonine kinase 3 (Ste20
Alias_symbol (synonym)MST2
KRS1
HGNC (Hugo) STK3
LocusID (NCBI) 6788
Atlas_Id 42439
Location 8q22.2  [Link to chromosome band 8q22]
Location_base_pair Starts at 99466859 and ends at 99954799 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ETV6 (12p13.2) / STK3 (8q22.2)MALAT1 (11q13.1) / STK3 (8q22.2)RNF19A (8q22.2) / STK3 (8q22.2)
SNHG3 (1p35.3) / STK3 (8q22.2)SNRNP48 (6p24.3) / STK3 (8q22.2)STK3 (8q22.2) / AC010859.1 ()
STK3 (8q22.2) / MKL1 (22q13.1)STK3 (8q22.2) / MRPL48 (11q13.4)STK3 (8q22.2) / NIPAL2 (8q22.2)
STK3 (8q22.2) / OXR1 (8q23.1)STK3 (8q22.2) / POLR2K (8q22.2)STK3 (8q22.2) / STK3 (8q22.2)
STK3 (8q22.2) / ZHX2 (8q24.13)SNRNP48 6p24.3 / STK3 8q22.2STK3 8q22.2 AC010859.1
STK3 8q22.2 / MRPL48 11q13.4STK3 8q22.2 / POLR2K 8q22.2STK3 8q22.2 / ZHX2 8q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STK3   11406
Cards
Entrez_Gene (NCBI)STK3  6788  serine/threonine kinase 3
AliasesKRS1; MST2
GeneCards (Weizmann)STK3
Ensembl hg19 (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000104375 [Gene_View]  chr8:99466859-99954799 [Contig_View]  STK3 [Vega]
ICGC DataPortalENSG00000104375
TCGA cBioPortalSTK3
AceView (NCBI)STK3
Genatlas (Paris)STK3
WikiGenes6788
SOURCE (Princeton)STK3
Genetics Home Reference (NIH)STK3
Genomic and cartography
GoldenPath hg19 (UCSC)STK3  -     chr8:99466859-99954799 -  8q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STK3  -     8q22.2   [Description]    (hg38-Dec_2013)
EnsemblSTK3 - 8q22.2 [CytoView hg19]  STK3 - 8q22.2 [CytoView hg38]
Mapping of homologs : NCBISTK3 [Mapview hg19]  STK3 [Mapview hg38]
OMIM605030   
Gene and transcription
Genbank (Entrez)AA370619 AK075229 AK131363 AK291837 AK307787
RefSeq transcript (Entrez)NM_001256312 NM_001256313 NM_006281
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929340
Consensus coding sequences : CCDS (NCBI)STK3
Cluster EST : UnigeneHs.738869 [ NCBI ]
CGAP (NCI)Hs.738869
Alternative Splicing GalleryENSG00000104375
Gene ExpressionSTK3 [ NCBI-GEO ]   STK3 [ EBI - ARRAY_EXPRESS ]   STK3 [ SEEK ]   STK3 [ MEM ]
Gene Expression Viewer (FireBrowse)STK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6788
GTEX Portal (Tissue expression)STK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13188   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13188  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13188
Splice isoforms : SwissVarQ13188
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ13188
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SARAH (PS50951)   
Domains : Interpro (EBI)Kinase-like_dom    Mst1_SARAH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    SARAH_dom    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam11629    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK3
DMDM Disease mutations6788
Blocks (Seattle)STK3
PDB (SRS)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
PDB (PDBSum)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
PDB (IMB)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
PDB (RSDB)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
Structural Biology KnowledgeBase3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
SCOP (Structural Classification of Proteins)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
CATH (Classification of proteins structures)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM   
SuperfamilyQ13188
Human Protein AtlasENSG00000104375
Peptide AtlasQ13188
HPRD05433
IPIIPI00942120   IPI00411984   IPI00974494   IPI00978085   IPI00168325   
Protein Interaction databases
DIP (DOE-UCLA)Q13188
IntAct (EBI)Q13188
FunCoupENSG00000104375
BioGRIDSTK3
STRING (EMBL)STK3
ZODIACSTK3
Ontologies - Pathways
QuickGOQ13188
Ontology : AmiGOmagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell proliferation  signal transduction by protein phosphorylation  positive regulation of protein binding  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein complex  protein serine/threonine kinase activator activity  positive regulation of fat cell differentiation  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  regulation of cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBImagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell proliferation  signal transduction by protein phosphorylation  positive regulation of protein binding  hippo signaling  hippo signaling  intracellular signal transduction  positive regulation of apoptotic process  protein complex  protein serine/threonine kinase activator activity  positive regulation of fat cell differentiation  positive regulation of JNK cascade  negative regulation of organ growth  protein dimerization activity  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  regulation of cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGMAPK signaling pathway    Hippo signaling pathway   
NDEx NetworkSTK3
Atlas of Cancer Signalling NetworkSTK3
Wikipedia pathwaysSTK3
Orthology - Evolution
OrthoDB6788
GeneTree (enSembl)ENSG00000104375
Phylogenetic Trees/Animal Genes : TreeFamSTK3
HOVERGENQ13188
HOGENOMQ13188
Homologs : HomoloGeneSTK3
Homology/Alignments : Family Browser (UCSC)STK3
Gene fusions - Rearrangements
Fusion : MitelmanSNRNP48/STK3 [6p24.3/8q22.2]  [t(6;8)(p24;q22)]  
Fusion : MitelmanSTK3/MRPL48 [8q22.2/11q13.4]  [t(8;11)(q22;q13)]  
Fusion : MitelmanSTK3/NIPAL2 [8q22.2/8q22.2]  [t(8;8)(q22;q22)]  
Fusion : MitelmanSTK3/POLR2K [8q22.2/8q22.2]  [t(8;8)(q22;q22)]  
Fusion : MitelmanSTK3/ZHX2 [8q22.2/8q24.13]  [t(8;8)(q22;q24)]  
Fusion: TCGASNRNP48 6p24.3 STK3 8q22.2 BRCA
Fusion: TCGASTK3 8q22.2 AC010859.1 LUAD
Fusion: TCGASTK3 8q22.2 MRPL48 11q13.4 BLCA
Fusion: TCGASTK3 8q22.2 POLR2K 8q22.2 BRCA
Fusion: TCGASTK3 8q22.2 ZHX2 8q24.13 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK3
dbVarSTK3
ClinVarSTK3
1000_GenomesSTK3 
Exome Variant ServerSTK3
ExAC (Exome Aggregation Consortium)STK3 (select the gene name)
Genetic variants : HAPMAP6788
Genomic Variants (DGV)STK3 [DGVbeta]
DECIPHER (Syndromes)8:99466859-99954799  ENSG00000104375
CONAN: Copy Number AnalysisSTK3 
Mutations
ICGC Data PortalSTK3 
TCGA Data PortalSTK3 
Broad Tumor PortalSTK3
OASIS PortalSTK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK3
DgiDB (Drug Gene Interaction Database)STK3
DoCM (Curated mutations)STK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK3 (select a term)
intoGenSTK3
Cancer3DSTK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605030   
Orphanet
MedgenSTK3
Genetic Testing Registry STK3
NextProtQ13188 [Medical]
TSGene6788
GENETestsSTK3
Huge Navigator STK3 [HugePedia]
snp3D : Map Gene to Disease6788
BioCentury BCIQSTK3
ClinGenSTK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6788
Chemical/Pharm GKB GenePA36213
Clinical trialSTK3
Miscellaneous
canSAR (ICR)STK3 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK3
EVEXSTK3
GoPubMedSTK3
iHOPSTK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:52:52 CET 2016

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