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STK3 (serine/threonine kinase 3)

Identity

Alias (NCBI)KRS1
MST2
HGNC (Hugo) STK3
HGNC Alias symbMST2
KRS1
HGNC Alias namehippo (Drosophila) homolog
HGNC Previous nameserine/threonine kinase 3 (Ste20, yeast homolog)
LocusID (NCBI) 6788
Atlas_Id 42439
Location 8q22.2  [Link to chromosome band 8q22]
Location_base_pair Starts at 98454633 and ends at 98825688 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / STK3 (8q22.2)MALAT1 (11q13.1) / STK3 (8q22.2)RNF19A (8q22.2) / STK3 (8q22.2)
SNHG3 (1p35.3) / STK3 (8q22.2)SNRNP48 (6p24.3) / STK3 (8q22.2)STK3 (8q22.2) / AC010859.1 ()
STK3 (8q22.2) / MKL1 (22q13.1)STK3 (8q22.2) / MRPL48 (11q13.4)STK3 (8q22.2) / NIPAL2 (8q22.2)
STK3 (8q22.2) / OXR1 (8q23.1)STK3 (8q22.2) / POLR2K (8q22.2)STK3 (8q22.2) / STK3 (8q22.2)
STK3 (8q22.2) / ZHX2 (8q24.13)SNRNP48 6p24.3 / STK3 8q22.2STK3 8q22.2 AC010859.1
STK3 8q22.2 / MRPL48 11q13.4STK3 8q22.2 / POLR2K 8q22.2STK3 8q22.2 / ZHX2 8q24.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;12)(q22;p13) ETV6/STK3


External links

 

Nomenclature
HGNC (Hugo)STK3   11406
Cards
Entrez_Gene (NCBI)STK3    serine/threonine kinase 3
AliasesKRS1; MST2
GeneCards (Weizmann)STK3
Ensembl hg19 (Hinxton)ENSG00000104375 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104375 [Gene_View]  ENSG00000104375 [Sequence]  chr8:98454633-98825688 [Contig_View]  STK3 [Vega]
ICGC DataPortalENSG00000104375
TCGA cBioPortalSTK3
AceView (NCBI)STK3
Genatlas (Paris)STK3
SOURCE (Princeton)STK3
Genetics Home Reference (NIH)STK3
Genomic and cartography
GoldenPath hg38 (UCSC)STK3  -     chr8:98454633-98825688 -  8q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK3  -     8q22.2   [Description]    (hg19-Feb_2009)
GoldenPathSTK3 - 8q22.2 [CytoView hg19]  STK3 - 8q22.2 [CytoView hg38]
ImmunoBaseENSG00000104375
Genome Data Viewer NCBISTK3 [Mapview hg19]  
OMIM605030   
Gene and transcription
Genbank (Entrez)AA370619 AK075229 AK131363 AK291837 AK307787
RefSeq transcript (Entrez)NM_001256312 NM_001256313 NM_006281
Consensus coding sequences : CCDS (NCBI)STK3
Gene ExpressionSTK3 [ NCBI-GEO ]   STK3 [ EBI - ARRAY_EXPRESS ]   STK3 [ SEEK ]   STK3 [ MEM ]
Gene Expression Viewer (FireBrowse)STK3 [ Firebrowse - Broad ]
GenevisibleExpression of STK3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6788
GTEX Portal (Tissue expression)STK3
Human Protein AtlasENSG00000104375-STK3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13188   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13188  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13188
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13188
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    SARAH (PS50951)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Mst1_SARAH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    SARAH_dom   
Domain families : Pfam (Sanger)Mst1_SARAH (PF11629)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam11629    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK3
PDB (RSDB)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
PDB Europe3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
PDB (PDBSum)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
PDB (IMB)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
Structural Biology KnowledgeBase3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
SCOP (Structural Classification of Proteins)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
CATH (Classification of proteins structures)3WWS    4HKD    4L0N    4LG4    4LGD    4OH9    5BRM    5DH3    6AO5    6AR2   
SuperfamilyQ13188
AlphaFold pdb e-kbQ13188   
Human Protein Atlas [tissue]ENSG00000104375-STK3 [tissue]
HPRD05433
Protein Interaction databases
DIP (DOE-UCLA)Q13188
IntAct (EBI)Q13188
BioGRIDSTK3
STRING (EMBL)STK3
ZODIACSTK3
Ontologies - Pathways
QuickGOQ13188
Ontology : AmiGOmagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  protein phosphorylation  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell population proliferation  positive regulation of protein binding  activation of protein kinase activity  protein-containing complex  hippo signaling  hippo signaling  intracellular signal transduction  intracellular signal transduction  identical protein binding  positive regulation of apoptotic process  regulation of MAPK cascade  protein serine/threonine kinase activator activity  positive regulation of fat cell differentiation  positive regulation of JNK cascade  negative regulation of organ growth  protein stabilization  positive regulation of DNA-binding transcription factor activity  protein tetramerization  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  regulation of cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  protein serine kinase activity  protein threonine kinase activity  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBImagnesium ion binding  neural tube formation  endocardium development  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  protein phosphorylation  protein phosphorylation  apoptotic process  signal transduction  central nervous system development  negative regulation of cell population proliferation  positive regulation of protein binding  activation of protein kinase activity  protein-containing complex  hippo signaling  hippo signaling  intracellular signal transduction  intracellular signal transduction  identical protein binding  positive regulation of apoptotic process  regulation of MAPK cascade  protein serine/threonine kinase activator activity  positive regulation of fat cell differentiation  positive regulation of JNK cascade  negative regulation of organ growth  protein stabilization  positive regulation of DNA-binding transcription factor activity  protein tetramerization  positive regulation of protein kinase B signaling  primitive hemopoiesis  cell differentiation involved in embryonic placenta development  regulation of cell differentiation involved in embryonic placenta development  positive regulation of protein serine/threonine kinase activity  negative regulation of canonical Wnt signaling pathway  hepatocyte apoptotic process  protein serine kinase activity  protein threonine kinase activity  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGMAPK signaling pathway    Hippo signaling pathway   
NDEx NetworkSTK3
Atlas of Cancer Signalling NetworkSTK3
Wikipedia pathwaysSTK3
Orthology - Evolution
OrthoDB6788
GeneTree (enSembl)ENSG00000104375
Phylogenetic Trees/Animal Genes : TreeFamSTK3
Homologs : HomoloGeneSTK3
Homology/Alignments : Family Browser (UCSC)STK3
Gene fusions - Rearrangements
Fusion : MitelmanSNRNP48/STK3 [6p24.3/8q22.2]  
Fusion : MitelmanSTK3/MRPL48 [8q22.2/11q13.4]  
Fusion : MitelmanSTK3/NIPAL2 [8q22.2/8q22.2]  
Fusion : MitelmanSTK3/POLR2K [8q22.2/8q22.2]  
Fusion : MitelmanSTK3/ZHX2 [8q22.2/8q24.13]  
Fusion : QuiverSTK3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK3
dbVarSTK3
ClinVarSTK3
MonarchSTK3
1000_GenomesSTK3 
Exome Variant ServerSTK3
GNOMAD BrowserENSG00000104375
Varsome BrowserSTK3
ACMGSTK3 variants
VarityQ13188
Genomic Variants (DGV)STK3 [DGVbeta]
DECIPHERSTK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK3 
Mutations
ICGC Data PortalSTK3 
TCGA Data PortalSTK3 
Broad Tumor PortalSTK3
OASIS PortalSTK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTK3
Mutations and Diseases : HGMDSTK3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTK3
DgiDB (Drug Gene Interaction Database)STK3
DoCM (Curated mutations)STK3
CIViC (Clinical Interpretations of Variants in Cancer)STK3
Cancer3DSTK3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605030   
Orphanet
DisGeNETSTK3
MedgenSTK3
Genetic Testing Registry STK3
NextProtQ13188 [Medical]
GENETestsSTK3
Target ValidationSTK3
Huge Navigator STK3 [HugePedia]
ClinGenSTK3
Clinical trials, drugs, therapy
MyCancerGenomeSTK3
Protein Interactions : CTDSTK3
Pharm GKB GenePA36213
PharosQ13188
Clinical trialSTK3
Miscellaneous
canSAR (ICR)STK3
HarmonizomeSTK3
DataMed IndexSTK3
Probes
Litterature
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:33:36 CEST 2021

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