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STK39 (serine/threonine kinase 39)

Identity

Alias_namesserine threonine kinase 39
Alias_symbol (synonym)DCHT
SPAK
Other aliasPASK
HGNC (Hugo) STK39
LocusID (NCBI) 27347
Atlas_Id 43518
Location 2q24.3  [Link to chromosome band 2q24]
Location_base_pair Starts at 168810530 and ends at 169104105 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
COL6A3 (2q37.3) / STK39 (2q24.3)SP3 (2q31.1) / STK39 (2q24.3)STK39 (2q24.3) / B3GALT1 (2q24.3)
STK39 (2q24.3) / ITGB6 (2q24.2)STK39 (2q24.3) / MAT1A (10q23.1)STK39 (2q24.3) / NFIC (19p13.3)
STK39 (2q24.3) / PCNX1 (14q24.2)STK39 (2q24.3) / SCN3A (2q24.3)SP3 2q31.1 / STK39 2q24.3
STK39 2q24.3 / ITGB6 2q24.2STK39 2q24.3 / MAT1A 10q23.1STK39 2q24.3 / SCN3A 2q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)STK39   17717
Cards
Entrez_Gene (NCBI)STK39  27347  serine/threonine kinase 39
AliasesDCHT; PASK; SPAK
GeneCards (Weizmann)STK39
Ensembl hg19 (Hinxton)ENSG00000198648 [Gene_View]  chr2:168810530-169104105 [Contig_View]  STK39 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198648 [Gene_View]  chr2:168810530-169104105 [Contig_View]  STK39 [Vega]
ICGC DataPortalENSG00000198648
TCGA cBioPortalSTK39
AceView (NCBI)STK39
Genatlas (Paris)STK39
WikiGenes27347
SOURCE (Princeton)STK39
Genetics Home Reference (NIH)STK39
Genomic and cartography
GoldenPath hg19 (UCSC)STK39  -     chr2:168810530-169104105 -  2q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STK39  -     2q24.3   [Description]    (hg38-Dec_2013)
EnsemblSTK39 - 2q24.3 [CytoView hg19]  STK39 - 2q24.3 [CytoView hg38]
Mapping of homologs : NCBISTK39 [Mapview hg19]  STK39 [Mapview hg38]
OMIM607648   
Gene and transcription
Genbank (Entrez)AF017635 AF030403 AF099989 AK126343 BC146813
RefSeq transcript (Entrez)NM_013233
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)STK39
Cluster EST : UnigeneHs.276271 [ NCBI ]
CGAP (NCI)Hs.276271
Alternative Splicing GalleryENSG00000198648
Gene ExpressionSTK39 [ NCBI-GEO ]   STK39 [ EBI - ARRAY_EXPRESS ]   STK39 [ SEEK ]   STK39 [ MEM ]
Gene Expression Viewer (FireBrowse)STK39 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27347
GTEX Portal (Tissue expression)STK39
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UEW8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UEW8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UEW8
Splice isoforms : SwissVarQ9UEW8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ9UEW8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Kinase_OSR1/WNK_CCT    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)OSR1_C (PF12202)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam12202    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK39
DMDM Disease mutations27347
Blocks (Seattle)STK39
SuperfamilyQ9UEW8
Human Protein AtlasENSG00000198648
Peptide AtlasQ9UEW8
HPRD09627
IPIIPI00973560   IPI00004363   
Protein Interaction databases
DIP (DOE-UCLA)Q9UEW8
IntAct (EBI)Q9UEW8
FunCoupENSG00000198648
BioGRIDSTK39
STRING (EMBL)STK39
ZODIACSTK39
Ontologies - Pathways
QuickGOQ9UEW8
Ontology : AmiGOnegative regulation of protein phosphorylation  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  protein phosphorylation  response to stress  regulation of blood pressure  basolateral plasma membrane  apical plasma membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  signal transduction by protein phosphorylation  intracellular signal transduction  positive regulation of potassium ion transport  regulation of inflammatory response  cellular hypotonic response  negative regulation of pancreatic juice secretion  negative regulation of potassium ion transmembrane transporter activity  negative regulation of potassium ion transmembrane transport  regulation of ion homeostasis  negative regulation of rubidium ion transport  negative regulation of rubidium ion transmembrane transporter activity  
Ontology : EGO-EBInegative regulation of protein phosphorylation  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytoskeleton  protein phosphorylation  response to stress  regulation of blood pressure  basolateral plasma membrane  apical plasma membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  signal transduction by protein phosphorylation  intracellular signal transduction  positive regulation of potassium ion transport  regulation of inflammatory response  cellular hypotonic response  negative regulation of pancreatic juice secretion  negative regulation of potassium ion transmembrane transporter activity  negative regulation of potassium ion transmembrane transport  regulation of ion homeostasis  negative regulation of rubidium ion transport  negative regulation of rubidium ion transmembrane transporter activity  
NDEx NetworkSTK39
Atlas of Cancer Signalling NetworkSTK39
Wikipedia pathwaysSTK39
Orthology - Evolution
OrthoDB27347
GeneTree (enSembl)ENSG00000198648
Phylogenetic Trees/Animal Genes : TreeFamSTK39
HOVERGENQ9UEW8
HOGENOMQ9UEW8
Homologs : HomoloGeneSTK39
Homology/Alignments : Family Browser (UCSC)STK39
Gene fusions - Rearrangements
Fusion : MitelmanSP3/STK39 [2q31.1/2q24.3]  [t(2;2)(q24;q31)]  
Fusion : MitelmanSTK39/B3GALT1 [2q24.3/2q24.3]  [t(2;2)(q24;q24)]  
Fusion : MitelmanSTK39/ITGB6 [2q24.3/2q24.2]  [t(2;2)(q24;q24)]  
Fusion : MitelmanSTK39/MAT1A [2q24.3/10q23.1]  [t(2;10)(q24;q23)]  
Fusion : MitelmanSTK39/SCN3A [2q24.3/2q24.3]  [t(2;2)(q24;q24)]  
Fusion: TCGASP3 2q31.1 STK39 2q24.3 LUSC
Fusion: TCGASTK39 2q24.3 ITGB6 2q24.2 BRCA
Fusion: TCGASTK39 2q24.3 MAT1A 10q23.1 BRCA
Fusion: TCGASTK39 2q24.3 SCN3A 2q24.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK39 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK39
dbVarSTK39
ClinVarSTK39
1000_GenomesSTK39 
Exome Variant ServerSTK39
ExAC (Exome Aggregation Consortium)STK39 (select the gene name)
Genetic variants : HAPMAP27347
Genomic Variants (DGV)STK39 [DGVbeta]
DECIPHER (Syndromes)2:168810530-169104105  ENSG00000198648
CONAN: Copy Number AnalysisSTK39 
Mutations
ICGC Data PortalSTK39 
TCGA Data PortalSTK39 
Broad Tumor PortalSTK39
OASIS PortalSTK39 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK39  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK39
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK39
DgiDB (Drug Gene Interaction Database)STK39
DoCM (Curated mutations)STK39 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK39 (select a term)
intoGenSTK39
Cancer3DSTK39(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607648   
Orphanet
MedgenSTK39
Genetic Testing Registry STK39
NextProtQ9UEW8 [Medical]
TSGene27347
GENETestsSTK39
Huge Navigator STK39 [HugePedia]
snp3D : Map Gene to Disease27347
BioCentury BCIQSTK39
ClinGenSTK39
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27347
Chemical/Pharm GKB GenePA38243
Clinical trialSTK39
Miscellaneous
canSAR (ICR)STK39 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK39
EVEXSTK39
GoPubMedSTK39
iHOPSTK39
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:29:41 CET 2017

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