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STK40 (serine/threonine kinase 40)

Identity

Alias_symbol (synonym)MGC4796
SgK495
Other aliasSHIK
HGNC (Hugo) STK40
LocusID (NCBI) 83931
Atlas_Id 74311
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 36339619 and ends at 36385927 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IDI2-AS1 (10p15.3) / STK40 (1p34.3)LSM10 (1p34.3) / STK40 (1p34.3)QDPR (4p15.32) / STK40 (1p34.3)
RHOBTB2 (8p21.3) / STK40 (1p34.3)STK40 (1p34.3) / MDM4 (1q32.1)STK40 (1p34.3) / STK40 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STK40   21373
Cards
Entrez_Gene (NCBI)STK40  83931  serine/threonine kinase 40
AliasesSHIK; SgK495
GeneCards (Weizmann)STK40
Ensembl hg19 (Hinxton)ENSG00000196182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196182 [Gene_View]  chr1:36339619-36385927 [Contig_View]  STK40 [Vega]
ICGC DataPortalENSG00000196182
TCGA cBioPortalSTK40
AceView (NCBI)STK40
Genatlas (Paris)STK40
WikiGenes83931
SOURCE (Princeton)STK40
Genetics Home Reference (NIH)STK40
Genomic and cartography
GoldenPath hg38 (UCSC)STK40  -     chr1:36339619-36385927 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STK40  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblSTK40 - 1p34.3 [CytoView hg19]  STK40 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBISTK40 [Mapview hg19]  STK40 [Mapview hg38]
OMIM609437   
Gene and transcription
Genbank (Entrez)AK000808 AK024504 AK075029 AK075048 AK131560
RefSeq transcript (Entrez)NM_001282546 NM_001282547 NM_032017
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STK40
Cluster EST : UnigeneHs.471768 [ NCBI ]
CGAP (NCI)Hs.471768
Alternative Splicing GalleryENSG00000196182
Gene ExpressionSTK40 [ NCBI-GEO ]   STK40 [ EBI - ARRAY_EXPRESS ]   STK40 [ SEEK ]   STK40 [ MEM ]
Gene Expression Viewer (FireBrowse)STK40 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83931
GTEX Portal (Tissue expression)STK40
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N2I9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N2I9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N2I9
Splice isoforms : SwissVarQ8N2I9
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8N2I9
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_40    Ser/Thr_kinase_AS    Tribbles/Ser_Thr_kinase_40   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)STK40
DMDM Disease mutations83931
Blocks (Seattle)STK40
PDB (SRS)5L2Q   
PDB (PDBSum)5L2Q   
PDB (IMB)5L2Q   
PDB (RSDB)5L2Q   
Structural Biology KnowledgeBase5L2Q   
SCOP (Structural Classification of Proteins)5L2Q   
CATH (Classification of proteins structures)5L2Q   
SuperfamilyQ8N2I9
Human Protein AtlasENSG00000196182
Peptide AtlasQ8N2I9
HPRD11359
IPIIPI00644404   IPI00790155   IPI00161013   IPI00181701   
Protein Interaction databases
DIP (DOE-UCLA)Q8N2I9
IntAct (EBI)Q8N2I9
FunCoupENSG00000196182
BioGRIDSTK40
STRING (EMBL)STK40
ZODIACSTK40
Ontologies - Pathways
QuickGOQ8N2I9
Ontology : AmiGOrespiratory system process  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  glycogen metabolic process  protein phosphorylation  regulation of gene expression  multicellular organism growth  negative regulation of apoptotic process  regulation of MAPK cascade  lung alveolus development  lung morphogenesis  
Ontology : EGO-EBIrespiratory system process  protein serine/threonine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  glycogen metabolic process  protein phosphorylation  regulation of gene expression  multicellular organism growth  negative regulation of apoptotic process  regulation of MAPK cascade  lung alveolus development  lung morphogenesis  
NDEx NetworkSTK40
Atlas of Cancer Signalling NetworkSTK40
Wikipedia pathwaysSTK40
Orthology - Evolution
OrthoDB83931
GeneTree (enSembl)ENSG00000196182
Phylogenetic Trees/Animal Genes : TreeFamSTK40
HOVERGENQ8N2I9
HOGENOMQ8N2I9
Homologs : HomoloGeneSTK40
Homology/Alignments : Family Browser (UCSC)STK40
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTK40 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STK40
dbVarSTK40
ClinVarSTK40
1000_GenomesSTK40 
Exome Variant ServerSTK40
ExAC (Exome Aggregation Consortium)STK40 (select the gene name)
Genetic variants : HAPMAP83931
Genomic Variants (DGV)STK40 [DGVbeta]
DECIPHERSTK40 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTK40 
Mutations
ICGC Data PortalSTK40 
TCGA Data PortalSTK40 
Broad Tumor PortalSTK40
OASIS PortalSTK40 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTK40  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTK40
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STK40
DgiDB (Drug Gene Interaction Database)STK40
DoCM (Curated mutations)STK40 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STK40 (select a term)
intoGenSTK40
Cancer3DSTK40(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609437   
Orphanet
MedgenSTK40
Genetic Testing Registry STK40
NextProtQ8N2I9 [Medical]
TSGene83931
GENETestsSTK40
Target ValidationSTK40
Huge Navigator STK40 [HugePedia]
snp3D : Map Gene to Disease83931
BioCentury BCIQSTK40
ClinGenSTK40
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83931
Chemical/Pharm GKB GenePA142670860
Clinical trialSTK40
Miscellaneous
canSAR (ICR)STK40 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTK40
EVEXSTK40
GoPubMedSTK40
iHOPSTK40
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:44:23 CEST 2017

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