STMN2 (stathmin 2)

2014-09-01  

Identity

HGNC
STMN2
LOCATION
8q21.13
LOCUSID
11075
ALIAS
SCG10,SCGN10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11075
MIM: 600621
HGNC: 10577
Ensembl: ENSG00000104435

Variants:

dbSNP: 11075
ClinVar: 11075
TCGA: ENSG00000104435
COSMIC: STMN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104435ENST00000220876Q93045
ENSG00000104435ENST00000518111Q93045
ENSG00000104435ENST00000518491E5RGX5

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
238932402014PAK4 kinase-mediated SCG10 phosphorylation involved in gastric cancer metastasis.26
306432922019ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair.26
212732912011IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia.24
306432982019Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.20
189968432009Rnd1 regulates axon extension by enhancing the microtubule destabilizing activity of SCG10.15
121402912002RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.13
173114102007Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth.13
186113922008Stathmin-like 2, a developmentally-associated neuronal marker, is expressed and modulated during osteogenesis of human mesenchymal stem cells.13
167127872006STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells.10
185492472008The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.8

Citation

Dessen P

STMN2 (stathmin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54882/stmn2