STON2 (stonin 2)

2018-07-01  

Identity

HGNC
LOCATION
14q31.1
LOCUSID
ALIAS
STN2,STNB,STNB2
FUSION GENES

Other Information

Locus ID:

NCBI: 85439
MIM: 608467
HGNC: 30652
Ensembl: ENSG00000140022

Variants:

dbSNP: 85439
ClinVar: 85439
TCGA: ENSG00000140022
COSMIC: STON2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140022ENST00000553821H0YJ05
ENSG00000140022ENST00000555447Q8WXE9
ENSG00000140022ENST00000557055G3V322
ENSG00000140022ENST00000614646Q8WXE9
ENSG00000140022ENST00000649389A0A3B3IU55

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164593022006Stonin 2 is an AP-2-dependent endocytic sorting adaptor for synaptotagmin internalization and recycling.62
181666562007Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2.29
214071392011Positive association of the human STON2 gene with schizophrenia.8
287589392017Stonin 2 Overexpression is Correlated with Unfavorable Prognosis and Tumor Invasion in Epithelial Ovarian Cancer.6
237853972013Cortical surface area correlates with STON2 gene Ser307Pro polymorphism in first-episode treatment-naïve patients with schizophrenia.4
305184242018STON2 negatively modulates stem-like properties in ovarian cancer cells via DNMT1/MUC1 pathway.4
303255822019miR-199b-5p-Stonin 2 axis regulates metastases and epithelial-to-mesenchymal transition of papillary thyroid carcinoma.3

Citation

Dessen P

STON2 (stonin 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57526/ston2