Identity
HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
LYK5,NY-BR-96,PMSE,STRAD,STRAD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 92335
MIM: 608626
HGNC: 30172
Ensembl: ENSG00000266173
Variants:
dbSNP: 92335
ClinVar: 92335
TCGA: ENSG00000266173
COSMIC: STRADA
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33247513 | 2021 | Two further cases of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, caused by a truncating variant in STRADA. | 2 |
| 33440120 | 2021 | Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα. | 4 |
| 33247513 | 2021 | Two further cases of polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, caused by a truncating variant in STRADA. | 2 |
| 33440120 | 2021 | Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα. | 4 |
| 27170158 | 2016 | Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). | 9 |
| 27170158 | 2016 | Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE). | 9 |
| 20424326 | 2010 | STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. | 65 |
| 20424326 | 2010 | STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. | 65 |
| 18854318 | 2009 | C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest. | 33 |
| 19386264 | 2009 | Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. | 89 |
| 19513107 | 2009 | ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. | 75 |
| 19892943 | 2009 | Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. | 160 |
| 18854318 | 2009 | C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest. | 33 |
| 19386264 | 2009 | Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. | 89 |
| 19513107 | 2009 | ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor. | 75 |
Citation
Dessen P
STRADA (STE20 related adaptor alpha)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45584/strada
