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STRADA (STE20-related kinase adaptor alpha)

Identity

Alias_symbol (synonym)NY-BR-96
LYK5
Stlk
STRAD
Other aliasPMSE
HGNC (Hugo) STRADA
LocusID (NCBI) 92335
Atlas_Id 45584
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63702832 and ends at 63741970 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PARK2 (6q26) / STRADA (17q23.3)STARD3 (17q12) / STRADA (17q23.3)STRADA (17q23.3) / AGBL4 (1p33)
TANC2 (17q23.2) / STRADA (17q23.3)TMEM218 (11q24.2) / STRADA (17q23.3)PARK2 6q26 / STRADA 17q23.3
STARD3 17q12 / STRADA 17q23.3TANC2 17q23.2 / STRADA 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STRADA   30172
Cards
Entrez_Gene (NCBI)STRADA  92335  STE20-related kinase adaptor alpha
AliasesLYK5; NY-BR-96; PMSE; STRAD; 
Stlk
GeneCards (Weizmann)STRADA
Ensembl hg19 (Hinxton)ENSG00000266173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000266173 [Gene_View]  chr17:63702832-63741970 [Contig_View]  STRADA [Vega]
ICGC DataPortalENSG00000266173
TCGA cBioPortalSTRADA
AceView (NCBI)STRADA
Genatlas (Paris)STRADA
WikiGenes92335
SOURCE (Princeton)STRADA
Genetics Home Reference (NIH)STRADA
Genomic and cartography
GoldenPath hg38 (UCSC)STRADA  -     chr17:63702832-63741970 -  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STRADA  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblSTRADA - 17q23.3 [CytoView hg19]  STRADA - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBISTRADA [Mapview hg19]  STRADA [Mapview hg38]
OMIM608626   611087   
Gene and transcription
Genbank (Entrez)AF308302 AK074771 AK075005 AK128173 AK293160
RefSeq transcript (Entrez)NM_001003786 NM_001003787 NM_001003788 NM_001165969 NM_001165970 NM_153335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STRADA
Cluster EST : UnigeneHs.514402 [ NCBI ]
CGAP (NCI)Hs.514402
Alternative Splicing GalleryENSG00000266173
Gene ExpressionSTRADA [ NCBI-GEO ]   STRADA [ EBI - ARRAY_EXPRESS ]   STRADA [ SEEK ]   STRADA [ MEM ]
Gene Expression Viewer (FireBrowse)STRADA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92335
GTEX Portal (Tissue expression)STRADA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7RTN6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7RTN6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7RTN6
Splice isoforms : SwissVarQ7RTN6
PhosPhoSitePlusQ7RTN6
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Conserved Domain (NCBI)STRADA
DMDM Disease mutations92335
Blocks (Seattle)STRADA
PDB (SRS)1UPK    2WTK    3GNI   
PDB (PDBSum)1UPK    2WTK    3GNI   
PDB (IMB)1UPK    2WTK    3GNI   
PDB (RSDB)1UPK    2WTK    3GNI   
Structural Biology KnowledgeBase1UPK    2WTK    3GNI   
SCOP (Structural Classification of Proteins)1UPK    2WTK    3GNI   
CATH (Classification of proteins structures)1UPK    2WTK    3GNI   
SuperfamilyQ7RTN6
Human Protein AtlasENSG00000266173
Peptide AtlasQ7RTN6
HPRD14332
IPIIPI00300700   IPI00396083   IPI00456673   IPI00873876   IPI00456050   IPI00947317   IPI00945374   
Protein Interaction databases
DIP (DOE-UCLA)Q7RTN6
IntAct (EBI)Q7RTN6
FunCoupENSG00000266173
BioGRIDSTRADA
STRING (EMBL)STRADA
ZODIACSTRADA
Ontologies - Pathways
QuickGOQ7RTN6
Ontology : AmiGOprotein kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  protein export from nucleus  cell cycle arrest  kinase binding  protein kinase activator activity  activation of protein kinase activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIprotein kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  protein export from nucleus  cell cycle arrest  kinase binding  protein kinase activator activity  activation of protein kinase activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Pathways : KEGGmTOR signaling pathway   
NDEx NetworkSTRADA
Atlas of Cancer Signalling NetworkSTRADA
Wikipedia pathwaysSTRADA
Orthology - Evolution
OrthoDB92335
GeneTree (enSembl)ENSG00000266173
Phylogenetic Trees/Animal Genes : TreeFamSTRADA
HOVERGENQ7RTN6
HOGENOMQ7RTN6
Homologs : HomoloGeneSTRADA
Homology/Alignments : Family Browser (UCSC)STRADA
Gene fusions - Rearrangements
Fusion : MitelmanPARK2/STRADA [6q26/17q23.3]  [t(6;17)(q26;q23)]  
Fusion : MitelmanSTARD3/STRADA [17q12/17q23.3]  [t(17;17)(q12;q23)]  
Fusion : MitelmanTANC2/STRADA [17q23.2/17q23.3]  [t(17;17)(q23;q23)]  
Fusion: TCGAPARK2 6q26 STRADA 17q23.3 LGG
Fusion: TCGASTARD3 17q12 STRADA 17q23.3 BRCA
Fusion: TCGATANC2 17q23.2 STRADA 17q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTRADA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STRADA
dbVarSTRADA
ClinVarSTRADA
1000_GenomesSTRADA 
Exome Variant ServerSTRADA
ExAC (Exome Aggregation Consortium)STRADA (select the gene name)
Genetic variants : HAPMAP92335
Genomic Variants (DGV)STRADA [DGVbeta]
DECIPHERSTRADA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTRADA 
Mutations
ICGC Data PortalSTRADA 
TCGA Data PortalSTRADA 
Broad Tumor PortalSTRADA
OASIS PortalSTRADA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTRADA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTRADA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STRADA
DgiDB (Drug Gene Interaction Database)STRADA
DoCM (Curated mutations)STRADA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STRADA (select a term)
intoGenSTRADA
Cancer3DSTRADA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608626    611087   
Orphanet
MedgenSTRADA
Genetic Testing Registry STRADA
NextProtQ7RTN6 [Medical]
TSGene92335
GENETestsSTRADA
Target ValidationSTRADA
Huge Navigator STRADA [HugePedia]
snp3D : Map Gene to Disease92335
BioCentury BCIQSTRADA
ClinGenSTRADA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92335
Chemical/Pharm GKB GenePA164726342
Clinical trialSTRADA
Miscellaneous
canSAR (ICR)STRADA (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTRADA
EVEXSTRADA
GoPubMedSTRADA
iHOPSTRADA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:16:01 CEST 2017

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