STRAP (serine/threonine kinase receptor associated protein)

2003-02-01  

Identity

HGNC
LOCATION
12p12.3
LOCUSID
ALIAS
MAWD,PT-WD,UNRIP
FUSION GENES

Other Information

Locus ID:

NCBI: 11171
MIM: 605986
HGNC: 30796
Ensembl: ENSG00000023734

Variants:

dbSNP: 11171
ClinVar: 11171
TCGA: ENSG00000023734
COSMIC: STRAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000023734ENST00000025399Q9Y3F4
ENSG00000023734ENST00000419869Q9Y3F4
ENSG00000023734ENST00000538718H0YH33
ENSG00000023734ENST00000541731F5H1G1

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Survival motor neuron (SMN) complexKEGGhsa_M00426
Survival motor neuron (SMN) complexKEGGM00426
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161598902005Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.36
158481702005Unrip is a component of SMN complexes active in snRNP assembly.31
170234152006Gemin8 is required for the architecture and function of the survival motor neuron complex.30
162511922005Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.27
173140992007NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.25
179843212007Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex.25
288273712017STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway.21
198805232010Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.16
201441492010MMP28 gene expression is regulated by Sp1 transcription factor acetylation.13
239188052013Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs.13

Citation

Dessen P

STRAP (serine/threonine kinase receptor associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42445/strap