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STRN3 (striatin 3)

Identity

Alias_namesstriatin
Alias_symbol (synonym)SG2NA
PPP2R6B
Other alias
HGNC (Hugo) STRN3
LocusID (NCBI) 29966
Atlas_Id 42446
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 31363005 and ends at 31495607 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AGO2 (8q24.3) / STRN3 (14q12)MAP3K3 (17q23.3) / STRN3 (14q12)STRN3 (14q12) / ACTR8 (3p21.1)
STRN3 (14q12) / C19orf66 (19p13.2)STRN3 (14q12) / DVL3 (3q27.1)STRN3 (14q12) / EGLN3 (14q13.1)
STRN3 (14q12) / JAK2 (9p24.1)STRN3 (14q12) / MAP3K3 (17q23.3)STRN3 (14q12) / METTL3 (14q11.2)
STRN3 (14q12) / PPP6R3 (11q13.2)STRN3 (14q12) / RNASE10 (14q11.2)STRN3 (14q12) / SCFD1 (14q12)
STRN3 14q12 / EGLN3 14q13.1STRN3 14q12 / METTL3 14q11.2STRN3 14q12 / PPP6R3 11q13.2
STRN3 14q12 / RNASE10 14q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;9)(q14.1;p24) SSBP2/JAK2


External links

Nomenclature
HGNC (Hugo)STRN3   15720
Cards
Entrez_Gene (NCBI)STRN3  29966  striatin 3
AliasesSG2NA
GeneCards (Weizmann)STRN3
Ensembl hg19 (Hinxton)ENSG00000196792 [Gene_View]  chr14:31363005-31495607 [Contig_View]  STRN3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196792 [Gene_View]  chr14:31363005-31495607 [Contig_View]  STRN3 [Vega]
ICGC DataPortalENSG00000196792
TCGA cBioPortalSTRN3
AceView (NCBI)STRN3
Genatlas (Paris)STRN3
WikiGenes29966
SOURCE (Princeton)STRN3
Genetics Home Reference (NIH)STRN3
Genomic and cartography
GoldenPath hg19 (UCSC)STRN3  -     chr14:31363005-31495607 -  14q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)STRN3  -     14q12   [Description]    (hg38-Dec_2013)
EnsemblSTRN3 - 14q12 [CytoView hg19]  STRN3 - 14q12 [CytoView hg38]
Mapping of homologs : NCBISTRN3 [Mapview hg19]  STRN3 [Mapview hg38]
OMIM614766   
Gene and transcription
Genbank (Entrez)AA572712 AF243424 AK290229 AK314041 AW070834
RefSeq transcript (Entrez)NM_001083893 NM_014574
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)STRN3
Cluster EST : UnigeneHs.401843 [ NCBI ]
CGAP (NCI)Hs.401843
Alternative Splicing GalleryENSG00000196792
Gene ExpressionSTRN3 [ NCBI-GEO ]   STRN3 [ EBI - ARRAY_EXPRESS ]   STRN3 [ SEEK ]   STRN3 [ MEM ]
Gene Expression Viewer (FireBrowse)STRN3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29966
GTEX Portal (Tissue expression)STRN3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13033   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13033  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13033
Splice isoforms : SwissVarQ13033
PhosPhoSitePlusQ13033
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Striatin_N    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom   
Domain families : Pfam (Sanger)Striatin (PF08232)    WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam08232    pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)STRN3
DMDM Disease mutations29966
Blocks (Seattle)STRN3
PDB (SRS)4N6J   
PDB (PDBSum)4N6J   
PDB (IMB)4N6J   
PDB (RSDB)4N6J   
Structural Biology KnowledgeBase4N6J   
SCOP (Structural Classification of Proteins)4N6J   
CATH (Classification of proteins structures)4N6J   
SuperfamilyQ13033
Human Protein AtlasENSG00000196792
Peptide AtlasQ13033
HPRD11613
IPIIPI00011461   IPI00477001   IPI01024896   IPI01024769   IPI01025790   IPI01025912   
Protein Interaction databases
DIP (DOE-UCLA)Q13033
IntAct (EBI)Q13033
FunCoupENSG00000196792
BioGRIDSTRN3
STRING (EMBL)STRN3
ZODIACSTRN3
Ontologies - Pathways
QuickGOQ13033
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein phosphatase type 2A complex  transcription factor activity, sequence-specific DNA binding  protein binding  calmodulin binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  plasma membrane  dendrite  response to estradiol  protein complex binding  negative regulation of intracellular estrogen receptor signaling pathway  neuronal cell body  protein complex  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein phosphatase 2A binding  armadillo repeat domain binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein phosphatase type 2A complex  transcription factor activity, sequence-specific DNA binding  protein binding  calmodulin binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  plasma membrane  dendrite  response to estradiol  protein complex binding  negative regulation of intracellular estrogen receptor signaling pathway  neuronal cell body  protein complex  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  protein phosphatase 2A binding  armadillo repeat domain binding  
NDEx NetworkSTRN3
Atlas of Cancer Signalling NetworkSTRN3
Wikipedia pathwaysSTRN3
Orthology - Evolution
OrthoDB29966
GeneTree (enSembl)ENSG00000196792
Phylogenetic Trees/Animal Genes : TreeFamSTRN3
HOVERGENQ13033
HOGENOMQ13033
Homologs : HomoloGeneSTRN3
Homology/Alignments : Family Browser (UCSC)STRN3
Gene fusions - Rearrangements
Fusion : MitelmanSTRN3/EGLN3 [14q12/14q13.1]  
Fusion : MitelmanSTRN3/JAK2 [14q12/9p24.1]  [t(9;14)(p24;q12)]  
Fusion : MitelmanSTRN3/METTL3 [14q12/14q11.2]  [t(14;14)(q11;q12)]  
Fusion : MitelmanSTRN3/PPP6R3 [14q12/11q13.2]  [t(11;14)(q13;q12)]  
Fusion : MitelmanSTRN3/RNASE10 [14q12/14q11.2]  [t(14;14)(q11;q12)]  
Fusion: TCGASTRN3 14q12 EGLN3 14q13.1 LUAD
Fusion: TCGASTRN3 14q12 METTL3 14q11.2 KIRC
Fusion: TCGASTRN3 14q12 PPP6R3 11q13.2 BRCA
Fusion: TCGASTRN3 14q12 RNASE10 14q11.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTRN3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STRN3
dbVarSTRN3
ClinVarSTRN3
1000_GenomesSTRN3 
Exome Variant ServerSTRN3
ExAC (Exome Aggregation Consortium)STRN3 (select the gene name)
Genetic variants : HAPMAP29966
Genomic Variants (DGV)STRN3 [DGVbeta]
DECIPHER (Syndromes)14:31363005-31495607  ENSG00000196792
CONAN: Copy Number AnalysisSTRN3 
Mutations
ICGC Data PortalSTRN3 
TCGA Data PortalSTRN3 
Broad Tumor PortalSTRN3
OASIS PortalSTRN3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTRN3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTRN3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STRN3
DgiDB (Drug Gene Interaction Database)STRN3
DoCM (Curated mutations)STRN3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STRN3 (select a term)
intoGenSTRN3
Cancer3DSTRN3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614766   
Orphanet
MedgenSTRN3
Genetic Testing Registry STRN3
NextProtQ13033 [Medical]
TSGene29966
GENETestsSTRN3
Huge Navigator STRN3 [HugePedia]
snp3D : Map Gene to Disease29966
BioCentury BCIQSTRN3
ClinGenSTRN3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29966
Chemical/Pharm GKB GenePA38394
Clinical trialSTRN3
Miscellaneous
canSAR (ICR)STRN3 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTRN3
EVEXSTRN3
GoPubMedSTRN3
iHOPSTRN3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:21:20 CEST 2017

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