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STT3A (STT3 oligosaccharyltransferase complex catalytic subunit A)

Identity

Alias (NCBI)ITM1
STT3-A
TMC
HGNC (Hugo) STT3A
HGNC Alias symbTMC
MGC9042
STT3-A
HGNC Alias namedolichyl-diphosphooligosaccharide protein glycotransferase
HGNC Previous nameITM1
HGNC Previous nameintegral membrane protein 1
 STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
 STT3A, catalytic subunit of the oligosaccharyltransferase complex
LocusID (NCBI) 3703
Atlas_Id 52275
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 125592852 and ends at 125623070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CARKD (13q34) / STT3A (11q24.2)STT3A (11q24.2) / CKB (14q32.32)STT3A (11q24.2) / GJA1 (6q22.31)
STT3A (11q24.2) / LIPG (18q21.1)STT3A (11q24.2) / LRRC47 (1p36.32)STT3A (11q24.2) / PTPN23 (3p21.31)
STT3A (11q24.2) / UBQLN4 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)STT3A   6172
Cards
Entrez_Gene (NCBI)STT3A    STT3 oligosaccharyltransferase complex catalytic subunit A
AliasesITM1; STT3-A; TMC
GeneCards (Weizmann)STT3A
Ensembl hg19 (Hinxton)ENSG00000134910 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134910 [Gene_View]  ENSG00000134910 [Sequence]  chr11:125592852-125623070 [Contig_View]  STT3A [Vega]
ICGC DataPortalENSG00000134910
TCGA cBioPortalSTT3A
AceView (NCBI)STT3A
Genatlas (Paris)STT3A
SOURCE (Princeton)STT3A
Genetics Home Reference (NIH)STT3A
Genomic and cartography
GoldenPath hg38 (UCSC)STT3A  -     chr11:125592852-125623070 +  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STT3A  -     11q24.2   [Description]    (hg19-Feb_2009)
GoldenPathSTT3A - 11q24.2 [CytoView hg19]  STT3A - 11q24.2 [CytoView hg38]
ImmunoBaseENSG00000134910
Genome Data Viewer NCBISTT3A [Mapview hg19]  
OMIM601134   615596   
Gene and transcription
Genbank (Entrez)AK130548 AK290040 AK290657 AK295892 AK308902
RefSeq transcript (Entrez)NM_001278503 NM_001278504 NM_152713
Consensus coding sequences : CCDS (NCBI)STT3A
Gene ExpressionSTT3A [ NCBI-GEO ]   STT3A [ EBI - ARRAY_EXPRESS ]   STT3A [ SEEK ]   STT3A [ MEM ]
Gene Expression Viewer (FireBrowse)STT3A [ Firebrowse - Broad ]
GenevisibleExpression of STT3A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3703
GTEX Portal (Tissue expression)STT3A
Human Protein AtlasENSG00000134910-STT3A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46977   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46977  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46977
Catalytic activity : Enzyme2.4.99.18 [ Enzyme-Expasy ]   2.4.99.182.4.99.18 [ IntEnz-EBI ]   2.4.99.18 [ BRENDA ]   2.4.99.18 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP46977
Domains : Interpro (EBI)Oligo_trans_STT3   
Domain families : Pfam (Sanger)STT3 (PF02516)   
Domain families : Pfam (NCBI)pfam02516   
Conserved Domain (NCBI)STT3A
PDB (RSDB)6S7O   
PDB Europe6S7O   
PDB (PDBSum)6S7O   
PDB (IMB)6S7O   
Structural Biology KnowledgeBase6S7O   
SCOP (Structural Classification of Proteins)6S7O   
CATH (Classification of proteins structures)6S7O   
SuperfamilyP46977
AlphaFold pdb e-kbP46977   
Human Protein Atlas [tissue]ENSG00000134910-STT3A [tissue]
HPRD03086
Protein Interaction databases
DIP (DOE-UCLA)P46977
IntAct (EBI)P46977
BioGRIDSTT3A
STRING (EMBL)STT3A
ZODIACSTT3A
Ontologies - Pathways
QuickGOP46977
Ontology : AmiGOdolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  protein binding  endoplasmic reticulum membrane  protein N-linked glycosylation  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  viral protein processing  oligosaccharyltransferase III complex  co-translational protein modification  post-translational protein modification  metal ion binding  
Ontology : EGO-EBIdolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  protein binding  endoplasmic reticulum membrane  protein N-linked glycosylation  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  viral protein processing  oligosaccharyltransferase III complex  co-translational protein modification  post-translational protein modification  metal ion binding  
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkSTT3A
Atlas of Cancer Signalling NetworkSTT3A
Wikipedia pathwaysSTT3A
Orthology - Evolution
OrthoDB3703
GeneTree (enSembl)ENSG00000134910
Phylogenetic Trees/Animal Genes : TreeFamSTT3A
Homologs : HomoloGeneSTT3A
Homology/Alignments : Family Browser (UCSC)STT3A
Gene fusions - Rearrangements
Fusion : QuiverSTT3A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTT3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STT3A
dbVarSTT3A
ClinVarSTT3A
MonarchSTT3A
1000_GenomesSTT3A 
Exome Variant ServerSTT3A
GNOMAD BrowserENSG00000134910
Varsome BrowserSTT3A
ACMGSTT3A variants
VarityP46977
Genomic Variants (DGV)STT3A [DGVbeta]
DECIPHERSTT3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTT3A 
Mutations
ICGC Data PortalSTT3A 
TCGA Data PortalSTT3A 
Broad Tumor PortalSTT3A
OASIS PortalSTT3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTT3A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTT3A
Mutations and Diseases : HGMDSTT3A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSTT3A
DgiDB (Drug Gene Interaction Database)STT3A
DoCM (Curated mutations)STT3A
CIViC (Clinical Interpretations of Variants in Cancer)STT3A
Cancer3DSTT3A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601134    615596   
Orphanet22500   
DisGeNETSTT3A
MedgenSTT3A
Genetic Testing Registry STT3A
NextProtP46977 [Medical]
GENETestsSTT3A
Target ValidationSTT3A
Huge Navigator STT3A [HugePedia]
ClinGenSTT3A (curated)
Clinical trials, drugs, therapy
MyCancerGenomeSTT3A
Protein Interactions : CTDSTT3A
Pharm GKB GenePA29969
PharosP46977
Clinical trialSTT3A
Miscellaneous
canSAR (ICR)STT3A
HarmonizomeSTT3A
DataMed IndexSTT3A
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSTT3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:33:42 CEST 2021

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