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STT3A (STT3A, catalytic subunit of the oligosaccharyltransferase complex)

Identity

Alias_namesITM1
integral membrane protein 1
STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Alias_symbol (synonym)TMC
MGC9042
STT3-A
Other alias
HGNC (Hugo) STT3A
LocusID (NCBI) 3703
Atlas_Id 52275
Location 11q24.2  [Link to chromosome band 11q24]
Location_base_pair Starts at 125592795 and ends at 125622759 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CARKD (13q34) / STT3A (11q24.2)STT3A (11q24.2) / CKB (14q32.32)STT3A (11q24.2) / GJA1 (6q22.31)
STT3A (11q24.2) / LIPG (18q21.1)STT3A (11q24.2) / LRRC47 (1p36.32)STT3A (11q24.2) / PTPN23 (3p21.31)
STT3A (11q24.2) / UBQLN4 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STT3A   6172
Cards
Entrez_Gene (NCBI)STT3A  3703  STT3A, catalytic subunit of the oligosaccharyltransferase complex
AliasesITM1; STT3-A; TMC
GeneCards (Weizmann)STT3A
Ensembl hg19 (Hinxton)ENSG00000134910 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134910 [Gene_View]  chr11:125592795-125622759 [Contig_View]  STT3A [Vega]
ICGC DataPortalENSG00000134910
TCGA cBioPortalSTT3A
AceView (NCBI)STT3A
Genatlas (Paris)STT3A
WikiGenes3703
SOURCE (Princeton)STT3A
Genetics Home Reference (NIH)STT3A
Genomic and cartography
GoldenPath hg38 (UCSC)STT3A  -     chr11:125592795-125622759 +  11q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STT3A  -     11q24.2   [Description]    (hg19-Feb_2009)
EnsemblSTT3A - 11q24.2 [CytoView hg19]  STT3A - 11q24.2 [CytoView hg38]
Mapping of homologs : NCBISTT3A [Mapview hg19]  STT3A [Mapview hg38]
OMIM601134   615596   
Gene and transcription
Genbank (Entrez)AK130548 AK290040 AK290657 AK295892 AK308902
RefSeq transcript (Entrez)NM_001278503 NM_001278504 NM_152713
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STT3A
Cluster EST : UnigeneHs.659244 [ NCBI ]
CGAP (NCI)Hs.659244
Alternative Splicing GalleryENSG00000134910
Gene ExpressionSTT3A [ NCBI-GEO ]   STT3A [ EBI - ARRAY_EXPRESS ]   STT3A [ SEEK ]   STT3A [ MEM ]
Gene Expression Viewer (FireBrowse)STT3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3703
GTEX Portal (Tissue expression)STT3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46977   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46977  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46977
Splice isoforms : SwissVarP46977
Catalytic activity : Enzyme2.4.99.18 [ Enzyme-Expasy ]   2.4.99.182.4.99.18 [ IntEnz-EBI ]   2.4.99.18 [ BRENDA ]   2.4.99.18 [ KEGG ]   
PhosPhoSitePlusP46977
Domains : Interpro (EBI)Oligo_trans_STT3   
Domain families : Pfam (Sanger)STT3 (PF02516)   
Domain families : Pfam (NCBI)pfam02516   
Conserved Domain (NCBI)STT3A
DMDM Disease mutations3703
Blocks (Seattle)STT3A
SuperfamilyP46977
Human Protein AtlasENSG00000134910
Peptide AtlasP46977
HPRD03086
IPIIPI00297492   IPI00979390   IPI00983309   IPI00984489   IPI00981261   IPI00976321   
Protein Interaction databases
DIP (DOE-UCLA)P46977
IntAct (EBI)P46977
FunCoupENSG00000134910
BioGRIDSTT3A
STRING (EMBL)STT3A
ZODIACSTT3A
Ontologies - Pathways
QuickGOP46977
Ontology : AmiGOdolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  protein binding  endoplasmic reticulum membrane  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  co-translational protein modification  post-translational protein modification  metal ion binding  
Ontology : EGO-EBIdolichyl-diphosphooligosaccharide-protein glycotransferase activity  dolichyl-diphosphooligosaccharide-protein glycotransferase activity  protein binding  endoplasmic reticulum membrane  oligosaccharyltransferase complex  oligosaccharyltransferase complex  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  co-translational protein modification  post-translational protein modification  metal ion binding  
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkSTT3A
Atlas of Cancer Signalling NetworkSTT3A
Wikipedia pathwaysSTT3A
Orthology - Evolution
OrthoDB3703
GeneTree (enSembl)ENSG00000134910
Phylogenetic Trees/Animal Genes : TreeFamSTT3A
HOVERGENP46977
HOGENOMP46977
Homologs : HomoloGeneSTT3A
Homology/Alignments : Family Browser (UCSC)STT3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTT3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STT3A
dbVarSTT3A
ClinVarSTT3A
1000_GenomesSTT3A 
Exome Variant ServerSTT3A
ExAC (Exome Aggregation Consortium)STT3A (select the gene name)
Genetic variants : HAPMAP3703
Genomic Variants (DGV)STT3A [DGVbeta]
DECIPHERSTT3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTT3A 
Mutations
ICGC Data PortalSTT3A 
TCGA Data PortalSTT3A 
Broad Tumor PortalSTT3A
OASIS PortalSTT3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTT3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTT3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STT3A
DgiDB (Drug Gene Interaction Database)STT3A
DoCM (Curated mutations)STT3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STT3A (select a term)
intoGenSTT3A
Cancer3DSTT3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601134    615596   
Orphanet22500   
MedgenSTT3A
Genetic Testing Registry STT3A
NextProtP46977 [Medical]
TSGene3703
GENETestsSTT3A
Target ValidationSTT3A
Huge Navigator STT3A [HugePedia]
snp3D : Map Gene to Disease3703
BioCentury BCIQSTT3A
ClinGenSTT3A (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3703
Chemical/Pharm GKB GenePA29969
Clinical trialSTT3A
Miscellaneous
canSAR (ICR)STT3A (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTT3A
EVEXSTT3A
GoPubMedSTT3A
iHOPSTT3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:58:01 CEST 2017

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