STX17 (syntaxin 17)

2009-05-01  

Identity

HGNC
LOCATION
9q31.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55014
MIM: 604204
HGNC: 11432
Ensembl: ENSG00000136874

Variants:

dbSNP: 55014
ClinVar: 55014
TCGA: ENSG00000136874
COSMIC: STX17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136874ENST00000259400P56962
ENSG00000136874ENST00000524405E9PIC2
ENSG00000136874ENST00000525342E9PJV6
ENSG00000136874ENST00000525640P56962
ENSG00000136874ENST00000526607E9PJW1
ENSG00000136874ENST00000529340E9PQU9
ENSG00000136874ENST00000531035E9PJW1
ENSG00000136874ENST00000534052P56962

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
Autophagy - animalKEGGko04140
SNARE interactions in vesicular transportKEGGhsa04130
Autophagy - animalKEGGhsa04140
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
232177092012The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes.337
205960222010Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.146
245547702014The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17.138
256199262015A role for the ancient SNARE syntaxin 17 in regulating mitochondrial division.42
294201922018Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.33
294201922018Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.33
286739652017Accumulation of autophagosomes confers cytotoxicity.26
283065022017Pacer Mediates the Function of Class III PI3K and HOPS Complexes in Autophagosome Maturation by Engaging Stx17.17
285042732017Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.17
290737202018MALAT1 modulates the autophagy of retinoblastoma cell through miR-124-mediated stx17 regulation.14

Citation

Dessen P

STX17 (syntaxin 17)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50884/stx17