Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STX1A (syntaxin 1A)

Identity

Alias_namesSTX1
syntaxin 1A (brain)
Alias_symbol (synonym)HPC-1
p35-1
Other aliasP35-1
SYN1A
HGNC (Hugo) STX1A
LocusID (NCBI) 6804
Atlas_Id 50519
Location 7q11.23  [Link to chromosome band 7q11]
Location_base_pair Starts at 73699205 and ends at 73719687 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and neck: Retinoblastoma


External links

Nomenclature
HGNC (Hugo)STX1A   11433
Cards
Entrez_Gene (NCBI)STX1A  6804  syntaxin 1A
AliasesHPC-1; P35-1; STX1; SYN1A
GeneCards (Weizmann)STX1A
Ensembl hg19 (Hinxton)ENSG00000106089 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106089 [Gene_View]  chr7:73699205-73719687 [Contig_View]  STX1A [Vega]
ICGC DataPortalENSG00000106089
TCGA cBioPortalSTX1A
AceView (NCBI)STX1A
Genatlas (Paris)STX1A
WikiGenes6804
SOURCE (Princeton)STX1A
Genetics Home Reference (NIH)STX1A
Genomic and cartography
GoldenPath hg38 (UCSC)STX1A  -     chr7:73699205-73719687 -  7q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STX1A  -     7q11.23   [Description]    (hg19-Feb_2009)
EnsemblSTX1A - 7q11.23 [CytoView hg19]  STX1A - 7q11.23 [CytoView hg38]
Mapping of homologs : NCBISTX1A [Mapview hg19]  STX1A [Mapview hg38]
OMIM186590   
Gene and transcription
Genbank (Entrez)AB086954 AI951874 AK299959 AK313980 BC000444
RefSeq transcript (Entrez)NM_001165903 NM_004603
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STX1A
Cluster EST : UnigeneHs.647024 [ NCBI ]
CGAP (NCI)Hs.647024
Alternative Splicing GalleryENSG00000106089
Gene ExpressionSTX1A [ NCBI-GEO ]   STX1A [ EBI - ARRAY_EXPRESS ]   STX1A [ SEEK ]   STX1A [ MEM ]
Gene Expression Viewer (FireBrowse)STX1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6804
GTEX Portal (Tissue expression)STX1A
Human Protein AtlasENSG00000106089-STX1A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16623   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16623  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16623
Splice isoforms : SwissVarQ16623
PhosPhoSitePlusQ16623
Domaine pattern : Prosite (Expaxy)SYNTAXIN (PS00914)    T_SNARE (PS50192)   
Domains : Interpro (EBI)SNARE    STX1A/1B    Syntaxin/epimorphin_CS    Syntaxin_N    T_SNARE_dom   
Domain families : Pfam (Sanger)SNARE (PF05739)    Syntaxin (PF00804)   
Domain families : Pfam (NCBI)pfam05739    pfam00804   
Domain families : Smart (EMBL)SynN (SM00503)  t_SNARE (SM00397)  
Conserved Domain (NCBI)STX1A
DMDM Disease mutations6804
Blocks (Seattle)STX1A
SuperfamilyQ16623
Human Protein Atlas [tissue]ENSG00000106089-STX1A [tissue]
Peptide AtlasQ16623
HPRD01721
IPIIPI00003370   IPI00221098   IPI00221099   IPI00909608   IPI00980923   IPI00792889   IPI00795234   
Protein Interaction databases
DIP (DOE-UCLA)Q16623
IntAct (EBI)Q16623
FunCoupENSG00000106089
BioGRIDSTX1A
STRING (EMBL)STX1A
ZODIACSTX1A
Ontologies - Pathways
QuickGOQ16623
Ontology : AmiGOSNARE binding  glycoprotein binding  positive regulation of neurotransmitter secretion  SNAP receptor activity  protein binding  extracellular region  cytosol  plasma membrane  plasma membrane  intracellular protein transport  neurotransmitter secretion  synaptic vesicle  voltage-gated potassium channel complex  response to gravity  positive regulation of norepinephrine secretion  regulation of synaptic vesicle priming  glutamate secretion  postsynaptic density  integral component of membrane  synaptic vesicle docking  myosin binding  calcium channel inhibitor activity  chloride channel inhibitor activity  kinase binding  protein domain specific binding  cell junction  secretory granule  synaptic vesicle membrane  protein binding, bridging  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  nuclear membrane  myosin head/neck binding  secretion by cell  positive regulation of catecholamine secretion  SNARE complex assembly  actomyosin  neuron projection  ATP-dependent protein binding  ion channel binding  positive regulation of calcium ion-dependent exocytosis  protein heterodimerization activity  protein N-terminus binding  vesicle docking  calcium-dependent protein binding  presynaptic active zone membrane  regulation of insulin secretion  regulation of molecular function  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  protein localization to membrane  positive regulation of excitatory postsynaptic potential  
Ontology : EGO-EBISNARE binding  glycoprotein binding  positive regulation of neurotransmitter secretion  SNAP receptor activity  protein binding  extracellular region  cytosol  plasma membrane  plasma membrane  intracellular protein transport  neurotransmitter secretion  synaptic vesicle  voltage-gated potassium channel complex  response to gravity  positive regulation of norepinephrine secretion  regulation of synaptic vesicle priming  glutamate secretion  postsynaptic density  integral component of membrane  synaptic vesicle docking  myosin binding  calcium channel inhibitor activity  chloride channel inhibitor activity  kinase binding  protein domain specific binding  cell junction  secretory granule  synaptic vesicle membrane  protein binding, bridging  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  nuclear membrane  myosin head/neck binding  secretion by cell  positive regulation of catecholamine secretion  SNARE complex assembly  actomyosin  neuron projection  ATP-dependent protein binding  ion channel binding  positive regulation of calcium ion-dependent exocytosis  protein heterodimerization activity  protein N-terminus binding  vesicle docking  calcium-dependent protein binding  presynaptic active zone membrane  regulation of insulin secretion  regulation of molecular function  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex  synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex  synaptobrevin 2-SNAP-25-syntaxin-1a complex  protein localization to membrane  positive regulation of excitatory postsynaptic potential  
Pathways : BIOCARTABlockade of Neurotransmitter Relase by Botulinum Toxin [Genes]   
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle    Insulin secretion    Amphetamine addiction   
NDEx NetworkSTX1A
Atlas of Cancer Signalling NetworkSTX1A
Wikipedia pathwaysSTX1A
Orthology - Evolution
OrthoDB6804
GeneTree (enSembl)ENSG00000106089
Phylogenetic Trees/Animal Genes : TreeFamSTX1A
HOVERGENQ16623
HOGENOMQ16623
Homologs : HomoloGeneSTX1A
Homology/Alignments : Family Browser (UCSC)STX1A
Gene fusions - Rearrangements
Fusion: Tumor Portal STX1A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTX1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STX1A
dbVarSTX1A
ClinVarSTX1A
1000_GenomesSTX1A 
Exome Variant ServerSTX1A
ExAC (Exome Aggregation Consortium)ENSG00000106089
GNOMAD BrowserENSG00000106089
Genetic variants : HAPMAP6804
Genomic Variants (DGV)STX1A [DGVbeta]
DECIPHERSTX1A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTX1A 
Mutations
ICGC Data PortalSTX1A 
TCGA Data PortalSTX1A 
Broad Tumor PortalSTX1A
OASIS PortalSTX1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTX1A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTX1A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STX1A
DgiDB (Drug Gene Interaction Database)STX1A
DoCM (Curated mutations)STX1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STX1A (select a term)
intoGenSTX1A
Cancer3DSTX1A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186590   
Orphanet49   
MedgenSTX1A
Genetic Testing Registry STX1A
NextProtQ16623 [Medical]
TSGene6804
GENETestsSTX1A
Target ValidationSTX1A
Huge Navigator STX1A [HugePedia]
snp3D : Map Gene to Disease6804
BioCentury BCIQSTX1A
ClinGenSTX1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6804
Chemical/Pharm GKB GenePA36233
Clinical trialSTX1A
Miscellaneous
canSAR (ICR)STX1A (select the gene name)
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTX1A
EVEXSTX1A
GoPubMedSTX1A
iHOPSTX1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 13:13:15 CET 2017

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