Atlas of Genetics and Cytogenetics in Oncology and Haematology

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STX1B (syntaxin 1B)

Identity

Alias_namesSTX1B1
STX1B2
syntaxin 1B1
syntaxin 1B2
Other aliasGEFSP9
HGNC (Hugo) STX1B
LocusID (NCBI) 112755
Atlas_Id 56157
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30989256 and ends at 31010638 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
STX1B (16p11.2) / GRIN1 (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)STX1B   18539
Cards
Entrez_Gene (NCBI)STX1B  112755  syntaxin 1B
AliasesGEFSP9; STX1B1; STX1B2
GeneCards (Weizmann)STX1B
Ensembl hg19 (Hinxton)ENSG00000099365 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000099365 [Gene_View]  ENSG00000099365 [Sequence]  chr16:30989256-31010638 [Contig_View]  STX1B [Vega]
ICGC DataPortalENSG00000099365
TCGA cBioPortalSTX1B
AceView (NCBI)STX1B
Genatlas (Paris)STX1B
WikiGenes112755
SOURCE (Princeton)STX1B
Genetics Home Reference (NIH)STX1B
Genomic and cartography
GoldenPath hg38 (UCSC)STX1B  -     chr16:30989256-31010638 -  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STX1B  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathSTX1B - 16p11.2 [CytoView hg19]  STX1B - 16p11.2 [CytoView hg38]
Genome Data Viewer NCBISTX1B [Mapview hg19]  
OMIM601485   616172   
Gene and transcription
Genbank (Entrez)AI084152 AK123137 AL713744 AL833259 AY028792
RefSeq transcript (Entrez)NM_052874
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STX1B
Alternative Splicing GalleryENSG00000099365
Gene ExpressionSTX1B [ NCBI-GEO ]   STX1B [ EBI - ARRAY_EXPRESS ]   STX1B [ SEEK ]   STX1B [ MEM ]
Gene Expression Viewer (FireBrowse)STX1B [ Firebrowse - Broad ]
GenevisibleExpression of STX1B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)112755
GTEX Portal (Tissue expression)STX1B
Human Protein AtlasENSG00000099365-STX1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61266   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61266  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61266
Splice isoforms : SwissVarP61266
PhosPhoSitePlusP61266
Domaine pattern : Prosite (Expaxy)SYNTAXIN (PS00914)    T_SNARE (PS50192)   
Domains : Interpro (EBI)SNARE    STX1    Syntaxin/epimorphin_CS    Syntaxin_N    T_SNARE_dom   
Domain families : Pfam (Sanger)SNARE (PF05739)    Syntaxin (PF00804)   
Domain families : Pfam (NCBI)pfam05739    pfam00804   
Domain families : Smart (EMBL)SynN (SM00503)  t_SNARE (SM00397)  
Conserved Domain (NCBI)STX1B
DMDM Disease mutations112755
SuperfamilyP61266
Human Protein Atlas [tissue]ENSG00000099365-STX1B [tissue]
Peptide AtlasP61266
HPRD18126
IPIIPI00410675   IPI00657774   IPI00428752   
Protein Interaction databases
DIP (DOE-UCLA)P61266
IntAct (EBI)P61266
FunCoupENSG00000099365
BioGRIDSTX1B
STRING (EMBL)STX1B
ZODIACSTX1B
Ontologies - Pathways
QuickGOP61266
Ontology : AmiGOSNARE binding  positive regulation of neurotransmitter secretion  signaling receptor binding  SNAP receptor activity  nucleus  microtubule organizing center  spindle  cytosol  plasma membrane  plasma membrane  plasma membrane  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  vesicle fusion  synaptic vesicle  regulation of gene expression  regulation of synaptic vesicle priming  negative regulation of neuron projection development  endomembrane system  membrane  integral component of membrane  synaptic vesicle docking  protein kinase binding  protein domain specific binding  axon  SNARE complex  neuromuscular junction  synaptic vesicle fusion to presynaptic active zone membrane  synaptic vesicle fusion to presynaptic active zone membrane  presynaptic membrane  vesicle docking  presynaptic active zone membrane  presynaptic active zone membrane  calcium ion-regulated exocytosis of neurotransmitter  regulation of synaptic activity  spontaneous neurotransmitter secretion  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  negative regulation of synaptic vesicle recycling  positive regulation of spontaneous neurotransmitter secretion  negative regulation of macropinocytosis  positive regulation of excitatory postsynaptic potential  
Ontology : EGO-EBISNARE binding  positive regulation of neurotransmitter secretion  signaling receptor binding  SNAP receptor activity  nucleus  microtubule organizing center  spindle  cytosol  plasma membrane  plasma membrane  plasma membrane  intracellular protein transport  exocytosis  vesicle docking involved in exocytosis  vesicle fusion  synaptic vesicle  regulation of gene expression  regulation of synaptic vesicle priming  negative regulation of neuron projection development  endomembrane system  membrane  integral component of membrane  synaptic vesicle docking  protein kinase binding  protein domain specific binding  axon  SNARE complex  neuromuscular junction  synaptic vesicle fusion to presynaptic active zone membrane  synaptic vesicle fusion to presynaptic active zone membrane  presynaptic membrane  vesicle docking  presynaptic active zone membrane  presynaptic active zone membrane  calcium ion-regulated exocytosis of neurotransmitter  regulation of synaptic activity  spontaneous neurotransmitter secretion  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  negative regulation of synaptic vesicle recycling  positive regulation of spontaneous neurotransmitter secretion  negative regulation of macropinocytosis  positive regulation of excitatory postsynaptic potential  
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle   
NDEx NetworkSTX1B
Atlas of Cancer Signalling NetworkSTX1B
Wikipedia pathwaysSTX1B
Orthology - Evolution
OrthoDB112755
GeneTree (enSembl)ENSG00000099365
Phylogenetic Trees/Animal Genes : TreeFamSTX1B
HOGENOMP61266
Homologs : HomoloGeneSTX1B
Homology/Alignments : Family Browser (UCSC)STX1B
Gene fusions - Rearrangements
Fusion : QuiverSTX1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTX1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STX1B
dbVarSTX1B
ClinVarSTX1B
1000_GenomesSTX1B 
Exome Variant ServerSTX1B
GNOMAD BrowserENSG00000099365
Varsome BrowserSTX1B
Genetic variants : HAPMAP112755
Genomic Variants (DGV)STX1B [DGVbeta]
DECIPHERSTX1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTX1B 
Mutations
ICGC Data PortalSTX1B 
TCGA Data PortalSTX1B 
Broad Tumor PortalSTX1B
OASIS PortalSTX1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTX1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSTX1B
Mutations and Diseases : HGMDSTX1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect STX1B
DgiDB (Drug Gene Interaction Database)STX1B
DoCM (Curated mutations)STX1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STX1B (select a term)
intoGenSTX1B
Cancer3DSTX1B (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601485    616172   
Orphanet10424   
DisGeNETSTX1B
MedgenSTX1B
Genetic Testing Registry STX1B
NextProtP61266 [Medical]
TSGene112755
GENETestsSTX1B
Open Targets GeneticsENSG00000099365  [validation]
snp3D : Map Gene to Disease112755
BioCentury BCIQSTX1B
ClinGenSTX1B
Clinical trials, drugs, therapy
Protein Interactions : CTD112755
Pharm GKB GenePA38345
Pharm GKB PathwaysPA162355621   
Clinical trialSTX1B
Miscellaneous
canSAR (ICR)STX1B (select the gene name)
HarmonizomeSTX1B
DataMed IndexSTX1B
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTX1B
EVEXSTX1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Jul 11 20:14:01 CEST 2020
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