STX2 (syntaxin 2)

2007-02-01  

Identity

HGNC
STX2
LOCATION
12q24.33
LOCUSID
2054
ALIAS
EPIM,EPM,STX2A,STX2B,STX2C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2054
MIM: 132350
HGNC: 3403
Ensembl: ENSG00000111450

Variants:

dbSNP: 2054
ClinVar: 2054
TCGA: ENSG00000111450
COSMIC: STX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111450ENST00000261653P32856
ENSG00000111450ENST00000344271J3KNU7
ENSG00000111450ENST00000392373P32856

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
220456762011Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis.30
211569302010Effect of genetic variations in syntaxin-binding protein-5 and syntaxin-2 on von Willebrand factor concentration and cardiovascular risk.18
121981392002Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.16
191292002009Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.15
227923892012Effect of genetic variation in STXBP5 and STX2 on von Willebrand factor and bleeding phenotype in type 1 von Willebrand disease patients.14
245783792014Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.12
298554622018STX2 promotes colorectal cancer metastasis through a positive feedback loop that activates the NF-κB pathway.6
182730502008Overexpression of extracellular epimorphin leads to impaired epidermal differentiation in HaCaT keratinocytes.5
174855532007SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane.4
240397872013Epimorphin-induced MET sensitizes ovarian cancer cells to platinum.4

Citation

Dessen P

STX2 (syntaxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45908/stx2