Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STX3 (syntaxin 3)

Identity

Alias_namesSTX3A
syntaxin 3A
Other alias
HGNC (Hugo) STX3
LocusID (NCBI) 6809
Atlas_Id 56217
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 59755059 and ends at 59805882 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HSPA8 (11q24.1) / STX3 (11q12.1)STX3 (11q12.1) / ATP5A1 (18q21.1)STX3 (11q12.1) / MEPCE (7q22.1)
STX3 (11q12.1) / STX3 (11q12.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STX3   11438
Cards
Entrez_Gene (NCBI)STX3  6809  syntaxin 3
AliasesSTX3A
GeneCards (Weizmann)STX3
Ensembl hg19 (Hinxton)ENSG00000166900 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166900 [Gene_View]  chr11:59755059-59805882 [Contig_View]  STX3 [Vega]
ICGC DataPortalENSG00000166900
TCGA cBioPortalSTX3
AceView (NCBI)STX3
Genatlas (Paris)STX3
WikiGenes6809
SOURCE (Princeton)STX3
Genetics Home Reference (NIH)STX3
Genomic and cartography
GoldenPath hg38 (UCSC)STX3  -     chr11:59755059-59805882 +  11q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STX3  -     11q12.1   [Description]    (hg19-Feb_2009)
EnsemblSTX3 - 11q12.1 [CytoView hg19]  STX3 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBISTX3 [Mapview hg19]  STX3 [Mapview hg38]
OMIM600876   
Gene and transcription
Genbank (Entrez)AA858058 AJ002076 AJ002077 AK055468 AK125660
RefSeq transcript (Entrez)NM_001178040 NM_004177
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STX3
Cluster EST : UnigeneHs.180711 [ NCBI ]
CGAP (NCI)Hs.180711
Alternative Splicing GalleryENSG00000166900
Gene ExpressionSTX3 [ NCBI-GEO ]   STX3 [ EBI - ARRAY_EXPRESS ]   STX3 [ SEEK ]   STX3 [ MEM ]
Gene Expression Viewer (FireBrowse)STX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6809
GTEX Portal (Tissue expression)STX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13277   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13277  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13277
Splice isoforms : SwissVarQ13277
PhosPhoSitePlusQ13277
Domaine pattern : Prosite (Expaxy)SYNTAXIN (PS00914)    T_SNARE (PS50192)   
Domains : Interpro (EBI)SNARE    Stx3    Syntaxin/epimorphin_CS    Syntaxin_N    T_SNARE_dom   
Domain families : Pfam (Sanger)SNARE (PF05739)    Syntaxin (PF00804)   
Domain families : Pfam (NCBI)pfam05739    pfam00804   
Domain families : Smart (EMBL)SynN (SM00503)  t_SNARE (SM00397)  
Conserved Domain (NCBI)STX3
DMDM Disease mutations6809
Blocks (Seattle)STX3
SuperfamilyQ13277
Human Protein AtlasENSG00000166900
Peptide AtlasQ13277
HPRD15985
IPIIPI00395768   IPI00220099   IPI00909631   IPI00982270   IPI00742798   IPI00979221   IPI00964617   
Protein Interaction databases
DIP (DOE-UCLA)Q13277
IntAct (EBI)Q13277
FunCoupENSG00000166900
BioGRIDSTX3
STRING (EMBL)STX3
ZODIACSTX3
Ontologies - Pathways
QuickGOQ13277
Ontology : AmiGOSNARE binding  SNAP receptor activity  protein binding  vacuole  plasma membrane  plasma membrane  cell-cell junction  intracellular protein transport  synaptic vesicle  positive regulation of cell proliferation  integral component of membrane  synaptic vesicle docking  apical plasma membrane  lamellipodium  dendrite  growth cone  neuron projection development  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  melanosome  specific granule  azurophil granule  zymogen granule membrane  presynaptic membrane  neuron projection  positive regulation of cell adhesion  vesicle docking  arachidonic acid binding  positive regulation of chemotaxis  long-term synaptic potentiation  extracellular exosome  ribbon synapse  postsynapse  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  positive regulation of protein localization to plasma membrane  photoreceptor cell terminal bouton  positive regulation of protein localization to cell surface  
Ontology : EGO-EBISNARE binding  SNAP receptor activity  protein binding  vacuole  plasma membrane  plasma membrane  cell-cell junction  intracellular protein transport  synaptic vesicle  positive regulation of cell proliferation  integral component of membrane  synaptic vesicle docking  apical plasma membrane  lamellipodium  dendrite  growth cone  neuron projection development  SNARE complex  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  melanosome  specific granule  azurophil granule  zymogen granule membrane  presynaptic membrane  neuron projection  positive regulation of cell adhesion  vesicle docking  arachidonic acid binding  positive regulation of chemotaxis  long-term synaptic potentiation  extracellular exosome  ribbon synapse  postsynapse  exocytic insertion of neurotransmitter receptor to postsynaptic membrane  positive regulation of protein localization to plasma membrane  photoreceptor cell terminal bouton  positive regulation of protein localization to cell surface  
Pathways : KEGGSNARE interactions in vesicular transport    Synaptic vesicle cycle   
NDEx NetworkSTX3
Atlas of Cancer Signalling NetworkSTX3
Wikipedia pathwaysSTX3
Orthology - Evolution
OrthoDB6809
GeneTree (enSembl)ENSG00000166900
Phylogenetic Trees/Animal Genes : TreeFamSTX3
HOVERGENQ13277
HOGENOMQ13277
Homologs : HomoloGeneSTX3
Homology/Alignments : Family Browser (UCSC)STX3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STX3
dbVarSTX3
ClinVarSTX3
1000_GenomesSTX3 
Exome Variant ServerSTX3
ExAC (Exome Aggregation Consortium)STX3 (select the gene name)
Genetic variants : HAPMAP6809
Genomic Variants (DGV)STX3 [DGVbeta]
DECIPHERSTX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTX3 
Mutations
ICGC Data PortalSTX3 
TCGA Data PortalSTX3 
Broad Tumor PortalSTX3
OASIS PortalSTX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STX3
DgiDB (Drug Gene Interaction Database)STX3
DoCM (Curated mutations)STX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STX3 (select a term)
intoGenSTX3
Cancer3DSTX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600876   
Orphanet2157   
MedgenSTX3
Genetic Testing Registry STX3
NextProtQ13277 [Medical]
TSGene6809
GENETestsSTX3
Target ValidationSTX3
Huge Navigator STX3 [HugePedia]
snp3D : Map Gene to Disease6809
BioCentury BCIQSTX3
ClinGenSTX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6809
Chemical/Pharm GKB GenePA36235
Clinical trialSTX3
Miscellaneous
canSAR (ICR)STX3 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTX3
EVEXSTX3
GoPubMedSTX3
iHOPSTX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:33:39 CEST 2017

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