Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STX4 (syntaxin 4)

Identity

Alias_namesSTX4A
syntaxin 4A (placental)
Alias_symbol (synonym)p35-2
Other alias
HGNC (Hugo) STX4
LocusID (NCBI) 6810
Atlas_Id 56250
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 31033491 and ends at 31040167 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ANKFY1 (17p13.2) / STX4 (16p11.2)STX4 (16p11.2) / HLA-C (6p21.33)STX4 (16p11.2) / KRT7 (12q13.13)
WDR1 (4p16.1) / STX4 (16p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STX4   11439
Cards
Entrez_Gene (NCBI)STX4  6810  syntaxin 4
AliasesSTX4A; p35-2
GeneCards (Weizmann)STX4
Ensembl hg19 (Hinxton)ENSG00000103496 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103496 [Gene_View]  chr16:31033491-31040167 [Contig_View]  STX4 [Vega]
ICGC DataPortalENSG00000103496
TCGA cBioPortalSTX4
AceView (NCBI)STX4
Genatlas (Paris)STX4
WikiGenes6810
SOURCE (Princeton)STX4
Genetics Home Reference (NIH)STX4
Genomic and cartography
GoldenPath hg38 (UCSC)STX4  -     chr16:31033491-31040167 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STX4  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblSTX4 - 16p11.2 [CytoView hg19]  STX4 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBISTX4 [Mapview hg19]  STX4 [Mapview hg38]
OMIM186591   
Gene and transcription
Genbank (Entrez)AF026007 AF318489 AJ000541 AK091833 AK296652
RefSeq transcript (Entrez)NM_001272095 NM_001272096 NM_004604
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STX4
Cluster EST : UnigeneHs.83734 [ NCBI ]
CGAP (NCI)Hs.83734
Alternative Splicing GalleryENSG00000103496
Gene ExpressionSTX4 [ NCBI-GEO ]   STX4 [ EBI - ARRAY_EXPRESS ]   STX4 [ SEEK ]   STX4 [ MEM ]
Gene Expression Viewer (FireBrowse)STX4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6810
GTEX Portal (Tissue expression)STX4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12846   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12846  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12846
Splice isoforms : SwissVarQ12846
PhosPhoSitePlusQ12846
Domaine pattern : Prosite (Expaxy)SYNTAXIN (PS00914)    T_SNARE (PS50192)   
Domains : Interpro (EBI)SNARE    Syntaxin/epimorphin_CS    Syntaxin_N    T_SNARE_dom   
Domain families : Pfam (Sanger)SNARE (PF05739)    Syntaxin (PF00804)   
Domain families : Pfam (NCBI)pfam05739    pfam00804   
Domain families : Smart (EMBL)SynN (SM00503)  t_SNARE (SM00397)  
Conserved Domain (NCBI)STX4
DMDM Disease mutations6810
Blocks (Seattle)STX4
SuperfamilyQ12846
Human Protein AtlasENSG00000103496
Peptide AtlasQ12846
HPRD01722
IPIIPI00029730   IPI00797749   IPI00798227   
Protein Interaction databases
DIP (DOE-UCLA)Q12846
IntAct (EBI)Q12846
FunCoupENSG00000103496
BioGRIDSTX4
STRING (EMBL)STX4
ZODIACSTX4
Ontologies - Pathways
QuickGOQ12846
Ontology : AmiGOSNARE binding  storage vacuole  SNAP receptor activity  protein binding  extracellular space  intracellular  endosome  vacuole  trans-Golgi network  cytosol  plasma membrane  plasma membrane  intracellular protein transport  post-Golgi vesicle-mediated transport  synaptic vesicle  positive regulation of cell proliferation  cell surface  membrane  integral component of membrane  sphingomyelin phosphodiesterase activator activity  basolateral plasma membrane  regulation of exocytosis  lamellipodium  positive regulation of cell migration  phagocytic vesicle membrane  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  response to hydroperoxide  SNARE complex assembly  myelin sheath adaxonal region  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of insulin secretion involved in cellular response to glucose stimulus  somatodendritic compartment  specific granule  positive regulation of catalytic activity  dendritic spine  lateral loop  positive regulation of eosinophil degranulation  synapse  positive regulation of cell adhesion  vesicle docking  organelle fusion  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of immunoglobulin secretion  long-term synaptic potentiation  extracellular exosome  positive regulation of establishment of protein localization to plasma membrane  regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of protein localization to plasma membrane  vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  positive regulation of protein localization to cell surface  
Ontology : EGO-EBISNARE binding  storage vacuole  SNAP receptor activity  protein binding  extracellular space  intracellular  endosome  vacuole  trans-Golgi network  cytosol  plasma membrane  plasma membrane  intracellular protein transport  post-Golgi vesicle-mediated transport  synaptic vesicle  positive regulation of cell proliferation  cell surface  membrane  integral component of membrane  sphingomyelin phosphodiesterase activator activity  basolateral plasma membrane  regulation of exocytosis  lamellipodium  positive regulation of cell migration  phagocytic vesicle membrane  SNARE complex  synaptic vesicle fusion to presynaptic active zone membrane  response to hydroperoxide  SNARE complex assembly  myelin sheath adaxonal region  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of insulin secretion involved in cellular response to glucose stimulus  somatodendritic compartment  specific granule  positive regulation of catalytic activity  dendritic spine  lateral loop  positive regulation of eosinophil degranulation  synapse  positive regulation of cell adhesion  vesicle docking  organelle fusion  perinuclear region of cytoplasm  positive regulation of chemotaxis  positive regulation of immunoglobulin secretion  long-term synaptic potentiation  extracellular exosome  positive regulation of establishment of protein localization to plasma membrane  regulation of extrinsic apoptotic signaling pathway via death domain receptors  positive regulation of protein localization to plasma membrane  vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane  positive regulation of protein localization to cell surface  
Pathways : KEGGSNARE interactions in vesicular transport    Vasopressin-regulated water reabsorption   
NDEx NetworkSTX4
Atlas of Cancer Signalling NetworkSTX4
Wikipedia pathwaysSTX4
Orthology - Evolution
OrthoDB6810
GeneTree (enSembl)ENSG00000103496
Phylogenetic Trees/Animal Genes : TreeFamSTX4
HOVERGENQ12846
HOGENOMQ12846
Homologs : HomoloGeneSTX4
Homology/Alignments : Family Browser (UCSC)STX4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTX4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STX4
dbVarSTX4
ClinVarSTX4
1000_GenomesSTX4 
Exome Variant ServerSTX4
ExAC (Exome Aggregation Consortium)STX4 (select the gene name)
Genetic variants : HAPMAP6810
Genomic Variants (DGV)STX4 [DGVbeta]
DECIPHERSTX4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTX4 
Mutations
ICGC Data PortalSTX4 
TCGA Data PortalSTX4 
Broad Tumor PortalSTX4
OASIS PortalSTX4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTX4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTX4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STX4
DgiDB (Drug Gene Interaction Database)STX4
DoCM (Curated mutations)STX4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STX4 (select a term)
intoGenSTX4
Cancer3DSTX4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186591   
Orphanet
MedgenSTX4
Genetic Testing Registry STX4
NextProtQ12846 [Medical]
TSGene6810
GENETestsSTX4
Target ValidationSTX4
Huge Navigator STX4 [HugePedia]
snp3D : Map Gene to Disease6810
BioCentury BCIQSTX4
ClinGenSTX4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6810
Chemical/Pharm GKB GenePA36236
Clinical trialSTX4
Miscellaneous
canSAR (ICR)STX4 (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTX4
EVEXSTX4
GoPubMedSTX4
iHOPSTX4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 14:08:55 CEST 2017

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