STX5 (syntaxin 5)

2016-10-01 Affiliation

Identity

HGNC

STX5

LOCATION

11q12.3

LOCUSID

6811

ALIAS

SED5,STX5A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6811
MIM: 603189
HGNC: 11440
Ensembl: ENSG00000162236

Variants:

dbSNP: 6811
ClinVar: 6811
TCGA: ENSG00000162236
COSMIC: STX5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000162236	ENST00000294179	Q13190
ENSG00000162236	ENST00000377897	Q13190
ENSG00000162236	ENST00000394690	Q13190
ENSG00000162236	ENST00000431400	H7C3X5
ENSG00000162236	ENST00000486437	E9PP18
ENSG00000162236	ENST00000488303	H0YEJ8
ENSG00000162236	ENST00000491231	E9PNU4
ENSG00000162236	ENST00000492066	E9PRW9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
SNARE interactions in vesicular transport	KEGG	ko04130
SNARE interactions in vesicular transport	KEGG	hsa04130
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
ER to Golgi Anterograde Transport	REACTOME	R-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle Transport	REACTOME	R-HSA-204005
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Cargo concentration in the ER	REACTOME	R-HSA-5694530
COPI-mediated anterograde transport	REACTOME	R-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER traffic	REACTOME	R-HSA-6811442
Intra-Golgi traffic	REACTOME	R-HSA-6811438

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17389686	2007	Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins.	48
21242315	2011	Autophagic substrate clearance requires activity of the syntaxin-5 SNARE complex.	48
19536132	2009	Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing.	43
18167358	2008	Coordination of golgin tethering and SNARE assembly: GM130 binds syntaxin 5 in a p115-regulated manner.	36
25410859	2015	Syntaxin 5-dependent retrograde transport to the trans-Golgi network is required for adeno-associated virus transduction.	24
16081076	2005	RNA interference-mediated silencing of the syntaxin 5 gene induces Golgi fragmentation but capable of transporting vesicles.	16
27404360	2016	Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.	10
21715015	2011	Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis.	4
23701949	2013	Stx5 is a novel interactor of VLDL-R to affect its intracellular trafficking and processing.	3

Citation

Dessen P

STX5 (syntaxin 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56302/stx5