STX6 (syntaxin 6)

2016-08-01  

Identity

HGNC
LOCATION
1q25.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10228
MIM: 603944
HGNC: 11441
Ensembl: ENSG00000135823

Variants:

dbSNP: 10228
ClinVar: 10228
TCGA: ENSG00000135823
COSMIC: STX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135823ENST00000258301O43752
ENSG00000135823ENST00000542060O43752

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218078812011The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport.42
210630202011Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6.41
247468152014Cholesterol regulates Syntaxin 6 trafficking at trans-Golgi network endosomal boundaries.38
201300902010Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator.37
211095602011The trans-Golgi SNARE syntaxin 6 is recruited to the chlamydial inclusion membrane.29
225738262012Regulation of integrin endocytic recycling and chemotactic cell migration by syntaxin 6 and VAMP3 interaction.28
224898842012Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6.25
218807372011Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling.23
238189892013Ubiquitination and degradation of CFTR by the E3 ubiquitin ligase MARCH2 through its association with adaptor proteins CAL and STX6.21
235854722013ATP11B mediates platinum resistance in ovarian cancer.19

Citation

Dessen P

STX6 (syntaxin 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-08-01

Online version: http://atlasgeneticsoncology.org/gene/55881/stx6