Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STX7 (syntaxin 7)

Identity

Other alias-
HGNC (Hugo) STX7
LocusID (NCBI) 8417
Atlas_Id 51151
Location 6q23.2  [Link to chromosome band 6q23]
Location_base_pair Starts at 132457524 and ends at 132513198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GANAB (11q12.3) / STX7 (6q23.2)LIN28B (6q16.3) / STX7 (6q23.2)STX7 (6q23.2) / STX7 (6q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(6)(q23) LIN28B/STX7


External links

Nomenclature
HGNC (Hugo)STX7   11442
Cards
Entrez_Gene (NCBI)STX7  8417  syntaxin 7
Aliases
GeneCards (Weizmann)STX7
Ensembl hg19 (Hinxton)ENSG00000079950 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079950 [Gene_View]  ENSG00000079950 [Sequence]  chr6:132457524-132513198 [Contig_View]  STX7 [Vega]
ICGC DataPortalENSG00000079950
TCGA cBioPortalSTX7
AceView (NCBI)STX7
Genatlas (Paris)STX7
WikiGenes8417
SOURCE (Princeton)STX7
Genetics Home Reference (NIH)STX7
Genomic and cartography
GoldenPath hg38 (UCSC)STX7  -     chr6:132457524-132513198 -  6q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STX7  -     6q23.2   [Description]    (hg19-Feb_2009)
EnsemblSTX7 - 6q23.2 [CytoView hg19]  STX7 - 6q23.2 [CytoView hg38]
Mapping of homologs : NCBISTX7 [Mapview hg19]  STX7 [Mapview hg38]
OMIM603217   
Gene and transcription
Genbank (Entrez)AF131808 AJ420529 AK294911 AK301464 AW500305
RefSeq transcript (Entrez)NM_001326578 NM_001326579 NM_001326580 NM_003569
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STX7
Cluster EST : UnigeneHs.605992 [ NCBI ]
CGAP (NCI)Hs.605992
Alternative Splicing GalleryENSG00000079950
Gene ExpressionSTX7 [ NCBI-GEO ]   STX7 [ EBI - ARRAY_EXPRESS ]   STX7 [ SEEK ]   STX7 [ MEM ]
Gene Expression Viewer (FireBrowse)STX7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8417
GTEX Portal (Tissue expression)STX7
Human Protein AtlasENSG00000079950-STX7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15400   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15400  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15400
Splice isoforms : SwissVarO15400
PhosPhoSitePlusO15400
Domaine pattern : Prosite (Expaxy)SYNTAXIN (PS00914)    T_SNARE (PS50192)   
Domains : Interpro (EBI)SNARE    Syntaxin/epimorphin_CS    Syntaxin_N    T_SNARE_dom   
Domain families : Pfam (Sanger)SNARE (PF05739)    Syntaxin_2 (PF14523)   
Domain families : Pfam (NCBI)pfam05739    pfam14523   
Domain families : Smart (EMBL)SynN (SM00503)  t_SNARE (SM00397)  
Conserved Domain (NCBI)STX7
DMDM Disease mutations8417
Blocks (Seattle)STX7
SuperfamilyO15400
Human Protein Atlas [tissue]ENSG00000079950-STX7 [tissue]
Peptide AtlasO15400
HPRD04449
IPIIPI00289876   IPI00552913   IPI00909094   IPI00910704   
Protein Interaction databases
DIP (DOE-UCLA)O15400
IntAct (EBI)O15400
FunCoupENSG00000079950
BioGRIDSTX7
STRING (EMBL)STX7
ZODIACSTX7
Ontologies - Pathways
QuickGOO15400
Ontology : AmiGOSNARE binding  SNARE binding  immunological synapse  positive regulation of T cell mediated cytotoxicity  SNAP receptor activity  protein binding  lysosome  lysosomal membrane  endosome  early endosome  late endosome  plasma membrane  intracellular protein transport  vesicle fusion  synaptic vesicle  endomembrane system  integral component of membrane  chloride channel inhibitor activity  syntaxin binding  endocytic vesicle  SNARE complex  early endosome membrane  vesicle  azurophil granule  vesicle docking  perinuclear region of cytoplasm  organelle localization  recycling endosome  extracellular exosome  tertiary granule  organelle assembly  positive regulation of receptor localization to synapse  regulation of protein localization to plasma membrane  
Ontology : EGO-EBISNARE binding  SNARE binding  immunological synapse  positive regulation of T cell mediated cytotoxicity  SNAP receptor activity  protein binding  lysosome  lysosomal membrane  endosome  early endosome  late endosome  plasma membrane  intracellular protein transport  vesicle fusion  synaptic vesicle  endomembrane system  integral component of membrane  chloride channel inhibitor activity  syntaxin binding  endocytic vesicle  SNARE complex  early endosome membrane  vesicle  azurophil granule  vesicle docking  perinuclear region of cytoplasm  organelle localization  recycling endosome  extracellular exosome  tertiary granule  organelle assembly  positive regulation of receptor localization to synapse  regulation of protein localization to plasma membrane  
Pathways : KEGGSNARE interactions in vesicular transport    Phagosome   
NDEx NetworkSTX7
Atlas of Cancer Signalling NetworkSTX7
Wikipedia pathwaysSTX7
Orthology - Evolution
OrthoDB8417
GeneTree (enSembl)ENSG00000079950
Phylogenetic Trees/Animal Genes : TreeFamSTX7
HOVERGENO15400
HOGENOMO15400
Homologs : HomoloGeneSTX7
Homology/Alignments : Family Browser (UCSC)STX7
Gene fusions - Rearrangements
Fusion : MitelmanLIN28B/STX7 [6q16.3/6q23.2]  [del(6)(q16)]  [del(6)(q16q23)]  
[del(6)(q23)]  
Fusion : QuiverSTX7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTX7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STX7
dbVarSTX7
ClinVarSTX7
1000_GenomesSTX7 
Exome Variant ServerSTX7
ExAC (Exome Aggregation Consortium)ENSG00000079950
GNOMAD BrowserENSG00000079950
Varsome BrowserSTX7
Genetic variants : HAPMAP8417
Genomic Variants (DGV)STX7 [DGVbeta]
DECIPHERSTX7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTX7 
Mutations
ICGC Data PortalSTX7 
TCGA Data PortalSTX7 
Broad Tumor PortalSTX7
OASIS PortalSTX7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTX7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTX7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STX7
DgiDB (Drug Gene Interaction Database)STX7
DoCM (Curated mutations)STX7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STX7 (select a term)
intoGenSTX7
Cancer3DSTX7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603217   
Orphanet
DisGeNETSTX7
MedgenSTX7
Genetic Testing Registry STX7
NextProtO15400 [Medical]
TSGene8417
GENETestsSTX7
Target ValidationSTX7
Huge Navigator STX7 [HugePedia]
snp3D : Map Gene to Disease8417
BioCentury BCIQSTX7
ClinGenSTX7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8417
Chemical/Pharm GKB GenePA36239
Clinical trialSTX7
Miscellaneous
canSAR (ICR)STX7 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTX7
EVEXSTX7
GoPubMedSTX7
iHOPSTX7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:42:51 CET 2018

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