Atlas of Genetics and Cytogenetics in Oncology and Haematology


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STYK1 (serine/threonine/tyrosine kinase 1)

Identity

Alias_symbol (synonym)SuRTK106
DKFZp761P1010
NOK
Other alias
HGNC (Hugo) STYK1
LocusID (NCBI) 55359
Atlas_Id 43519
Location 12p13.2  [Link to chromosome band 12p13]
Location_base_pair Starts at 10618939 and ends at 10674292 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LRP6 (12p13.2) / STYK1 (12p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)STYK1   18889
Cards
Entrez_Gene (NCBI)STYK1  55359  serine/threonine/tyrosine kinase 1
AliasesNOK; SuRTK106
GeneCards (Weizmann)STYK1
Ensembl hg19 (Hinxton)ENSG00000060140 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000060140 [Gene_View]  chr12:10618939-10674292 [Contig_View]  STYK1 [Vega]
ICGC DataPortalENSG00000060140
TCGA cBioPortalSTYK1
AceView (NCBI)STYK1
Genatlas (Paris)STYK1
WikiGenes55359
SOURCE (Princeton)STYK1
Genetics Home Reference (NIH)STYK1
Genomic and cartography
GoldenPath hg38 (UCSC)STYK1  -     chr12:10618939-10674292 -  12p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)STYK1  -     12p13.2   [Description]    (hg19-Feb_2009)
EnsemblSTYK1 - 12p13.2 [CytoView hg19]  STYK1 - 12p13.2 [CytoView hg38]
Mapping of homologs : NCBISTYK1 [Mapview hg19]  STYK1 [Mapview hg38]
OMIM611433   
Gene and transcription
Genbank (Entrez)AF251059 AK313906 AL353940 AM393808 AY563054
RefSeq transcript (Entrez)NM_018423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)STYK1
Cluster EST : UnigeneHs.24979 [ NCBI ]
CGAP (NCI)Hs.24979
Alternative Splicing GalleryENSG00000060140
Gene ExpressionSTYK1 [ NCBI-GEO ]   STYK1 [ EBI - ARRAY_EXPRESS ]   STYK1 [ SEEK ]   STYK1 [ MEM ]
Gene Expression Viewer (FireBrowse)STYK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55359
GTEX Portal (Tissue expression)STYK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6J9G0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6J9G0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6J9G0
Splice isoforms : SwissVarQ6J9G0
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusQ6J9G0
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Tyr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Conserved Domain (NCBI)STYK1
DMDM Disease mutations55359
Blocks (Seattle)STYK1
SuperfamilyQ6J9G0
Human Protein AtlasENSG00000060140
Peptide AtlasQ6J9G0
HPRD15447
IPIIPI00387030   IPI01013042   IPI01012636   IPI01012216   IPI01010031   IPI01011343   
Protein Interaction databases
DIP (DOE-UCLA)Q6J9G0
IntAct (EBI)Q6J9G0
FunCoupENSG00000060140
BioGRIDSTYK1
STRING (EMBL)STYK1
ZODIACSTYK1
Ontologies - Pathways
QuickGOQ6J9G0
Ontology : AmiGOnon-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  plasma membrane  chemotaxis  cell adhesion  epidermal growth factor receptor signaling pathway  integral component of membrane  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  
Ontology : EGO-EBInon-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  plasma membrane  chemotaxis  cell adhesion  epidermal growth factor receptor signaling pathway  integral component of membrane  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  regulation of mast cell degranulation  innate immune response  
NDEx NetworkSTYK1
Atlas of Cancer Signalling NetworkSTYK1
Wikipedia pathwaysSTYK1
Orthology - Evolution
OrthoDB55359
GeneTree (enSembl)ENSG00000060140
Phylogenetic Trees/Animal Genes : TreeFamSTYK1
HOVERGENQ6J9G0
HOGENOMQ6J9G0
Homologs : HomoloGeneSTYK1
Homology/Alignments : Family Browser (UCSC)STYK1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSTYK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)STYK1
dbVarSTYK1
ClinVarSTYK1
1000_GenomesSTYK1 
Exome Variant ServerSTYK1
ExAC (Exome Aggregation Consortium)STYK1 (select the gene name)
Genetic variants : HAPMAP55359
Genomic Variants (DGV)STYK1 [DGVbeta]
DECIPHERSTYK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSTYK1 
Mutations
ICGC Data PortalSTYK1 
TCGA Data PortalSTYK1 
Broad Tumor PortalSTYK1
OASIS PortalSTYK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSTYK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSTYK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch STYK1
DgiDB (Drug Gene Interaction Database)STYK1
DoCM (Curated mutations)STYK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)STYK1 (select a term)
intoGenSTYK1
Cancer3DSTYK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611433   
Orphanet
MedgenSTYK1
Genetic Testing Registry STYK1
NextProtQ6J9G0 [Medical]
TSGene55359
GENETestsSTYK1
Huge Navigator STYK1 [HugePedia]
snp3D : Map Gene to Disease55359
BioCentury BCIQSTYK1
ClinGenSTYK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55359
Chemical/Pharm GKB GenePA134976821
Clinical trialSTYK1
Miscellaneous
canSAR (ICR)STYK1 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSTYK1
EVEXSTYK1
GoPubMedSTYK1
iHOPSTYK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:39:46 CEST 2017

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