STYXL1 (serine/threonine/tyrosine interacting like 1)

2014-11-01  

Identity

HGNC
STYXL1
LOCATION
7q11.23
LOCUSID
51657
ALIAS
DUSP24,MK-STYX,MKSTYX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51657
MIM: 616695
HGNC: 18165
Ensembl: ENSG00000127952

Variants:

dbSNP: 51657
ClinVar: 51657
TCGA: ENSG00000127952
COSMIC: STYXL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127952ENST00000248600Q9Y6J8
ENSG00000127952ENST00000248600A0A024R4L1
ENSG00000127952ENST00000340062Q9Y6J8
ENSG00000127952ENST00000359697Q9Y6J8
ENSG00000127952ENST00000359697A0A024R4L1
ENSG00000127952ENST00000360591Q9Y6J8
ENSG00000127952ENST00000430497H7C1Y2
ENSG00000127952ENST00000431581Q9Y6J8
ENSG00000127952ENST00000431581A0A024R4L1
ENSG00000127952ENST00000438695H0Y6C4
ENSG00000127952ENST00000451157C9J4H0
ENSG00000127952ENST00000454618A0A0C4DG63

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201807782010The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation.14
212627712011MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.12
231638952013The pseudophosphatase MK-STYX inhibits stress granule assembly independently of Ser149 phosphorylation of G3BP-1.6
247099862014The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.4
257245872015Homozygous missense mutation in STYXL1 associated with moderate intellectual disability, epilepsy and behavioural complexities.2
309094122019Pseudophosphatase MK-STYX Alters Histone Deacetylase 6 Cytoplasmic Localization, Decreases Its Phosphorylation, and Increases Detyrosination of Tubulin.1
304724862019A previously identified missense mutation in STYXL1 is likely benign.0
311469102019Serine/threonine/tyrosine-interacting-like protein 1 (STYXL1), a pseudo phosphatase, promotes oncogenesis in glioma.0

Citation

Dessen P

STYXL1 (serine/threonine/tyrosine interacting like 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74350/styxl1