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SUCLA2 (succinate-CoA ligase ADP-forming subunit beta)

Identity

Alias (NCBI)A-BETA
A-SCS
LINC00444
MTDPS5
SCS-betaA
HGNC (Hugo) SUCLA2
HGNC Alias namesuccinate--CoA ligase (ADP-forming)
HGNC Previous namesuccinate-CoA ligase, ADP-forming, beta subunit
LocusID (NCBI) 8803
Atlas_Id 74351
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 47942656 and ends at 48001326 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTTNBP2NL (1p13.2) / SUCLA2 (13q14.2)SUCLA2 (13q14.2) / CASR (3q21.1)SUCLA2 (13q14.2) / FAAP20 (1p36.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;13)(p13;q14) CTTNBP2NL/SUCLA2
t(3;13)(q21;q14) SUCLA2/CASR

External links

Nomenclature
HGNC (Hugo)SUCLA2   11448
Cards
Entrez_Gene (NCBI)SUCLA2    succinate-CoA ligase ADP-forming subunit beta
AliasesA-BETA; A-SCS; LINC00444; MTDPS5; 
SCS-betaA
GeneCards (Weizmann)SUCLA2
Ensembl hg19 (Hinxton)ENSG00000136143 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136143 [Gene_View]  ENSG00000136143 [Sequence]  chr13:47942656-48001326 [Contig_View]  SUCLA2 [Vega]
ICGC DataPortalENSG00000136143
TCGA cBioPortalSUCLA2
AceView (NCBI)SUCLA2
Genatlas (Paris)SUCLA2
SOURCE (Princeton)SUCLA2
Genetics Home Reference (NIH)SUCLA2
Genomic and cartography
GoldenPath hg38 (UCSC)SUCLA2  -     chr13:47942656-48001326 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUCLA2  -     13q14.2   [Description]    (hg19-Feb_2009)
GoldenPathSUCLA2 - 13q14.2 [CytoView hg19]  SUCLA2 - 13q14.2 [CytoView hg38]
ImmunoBaseENSG00000136143
genome Data Viewer NCBISUCLA2 [Mapview hg19]  
OMIM603921   612073   
Gene and transcription
Genbank (Entrez)AB035863 AF058953 AF087890 AK001458 AK001847
RefSeq transcript (Entrez)NM_003850
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUCLA2
Alternative Splicing GalleryENSG00000136143
Gene ExpressionSUCLA2 [ NCBI-GEO ]   SUCLA2 [ EBI - ARRAY_EXPRESS ]   SUCLA2 [ SEEK ]   SUCLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)SUCLA2 [ Firebrowse - Broad ]
GenevisibleExpression of SUCLA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8803
GTEX Portal (Tissue expression)SUCLA2
Human Protein AtlasENSG00000136143-SUCLA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2R7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2R7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2R7
Splice isoforms : SwissVarQ9P2R7
PhosPhoSitePlusQ9P2R7
Domaine pattern : Prosite (Expaxy)ATP_GRASP (PS50975)    SUCCINYL_COA_LIG_3 (PS01217)   
Domains : Interpro (EBI)ATP-grasp    ATP-grasp_succ-CoA_synth-type    ATP_grasp_subdomain_1    CoA_ligase    Succ-CoA_synthase_bsu_CS    Succ_CoA_betaA_euk    Succ_CoA_synthase_bsu    Succinyl-CoA_synth-like   
Domain families : Pfam (Sanger)ATP-grasp_2 (PF08442)    Ligase_CoA (PF00549)   
Domain families : Pfam (NCBI)pfam08442    pfam00549   
Conserved Domain (NCBI)SUCLA2
Blocks (Seattle)SUCLA2
PDB (RSDB)6G4Q   
PDB Europe6G4Q   
PDB (PDBSum)6G4Q   
PDB (IMB)6G4Q   
Structural Biology KnowledgeBase6G4Q   
SCOP (Structural Classification of Proteins)6G4Q   
CATH (Classification of proteins structures)6G4Q   
SuperfamilyQ9P2R7
Human Protein Atlas [tissue]ENSG00000136143-SUCLA2 [tissue]
Peptide AtlasQ9P2R7
HPRD06798
IPIIPI00464979   IPI00217232   IPI01013225   IPI01013597   IPI00513883   IPI00514217   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2R7
IntAct (EBI)Q9P2R7
BioGRIDSUCLA2
STRING (EMBL)SUCLA2
ZODIACSUCLA2
Ontologies - Pathways
QuickGOQ9P2R7
Ontology : AmiGOmagnesium ion binding  succinate-CoA ligase (ADP-forming) activity  succinate-CoA ligase (ADP-forming) activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  tricarboxylic acid cycle  succinyl-CoA metabolic process  succinate metabolic process  succinyl-CoA pathway  succinate-CoA ligase complex  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  succinate-CoA ligase (ADP-forming) activity  succinate-CoA ligase (ADP-forming) activity  protein binding  ATP binding  mitochondrion  mitochondrion  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  tricarboxylic acid cycle  succinyl-CoA metabolic process  succinate metabolic process  succinyl-CoA pathway  succinate-CoA ligase complex  extracellular exosome  
Pathways : KEGGC5-Branched dibasic acid metabolism    Propanoate metabolism    Citrate cycle (TCA cycle)    Reductive carboxylate cycle (CO2 fixation)   
NDEx NetworkSUCLA2
Atlas of Cancer Signalling NetworkSUCLA2
Wikipedia pathwaysSUCLA2
Orthology - Evolution
OrthoDB8803
GeneTree (enSembl)ENSG00000136143
Phylogenetic Trees/Animal Genes : TreeFamSUCLA2
HOGENOMQ9P2R7
Homologs : HomoloGeneSUCLA2
Homology/Alignments : Family Browser (UCSC)SUCLA2
Gene fusions - Rearrangements
Fusion : QuiverSUCLA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUCLA2 [hg38]
dbVarSUCLA2
ClinVarSUCLA2
MonarchSUCLA2
1000_GenomesSUCLA2 
Exome Variant ServerSUCLA2
GNOMAD BrowserENSG00000136143
Varsome BrowserSUCLA2
Genomic Variants (DGV)SUCLA2 [DGVbeta]
DECIPHERSUCLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUCLA2 
Mutations
ICGC Data PortalSUCLA2 
TCGA Data PortalSUCLA2 
Broad Tumor PortalSUCLA2
OASIS PortalSUCLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUCLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUCLA2
Mutations and Diseases : HGMDSUCLA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SUCLA2
DgiDB (Drug Gene Interaction Database)SUCLA2
DoCM (Curated mutations)SUCLA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUCLA2 (select a term)
intoGenSUCLA2
Cancer3DSUCLA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603921    612073   
Orphanet491   
DisGeNETSUCLA2
MedgenSUCLA2
Genetic Testing Registry SUCLA2
NextProtQ9P2R7 [Medical]
GENETestsSUCLA2
Target ValidationSUCLA2
Huge Navigator SUCLA2 [HugePedia]
ClinGenSUCLA2
Clinical trials, drugs, therapy
MyCancerGenomeSUCLA2
Protein Interactions : CTD
Pharm GKB GenePA36245
Clinical trialSUCLA2
Miscellaneous
canSAR (ICR)SUCLA2 (select the gene name)
HarmonizomeSUCLA2
DataMed IndexSUCLA2
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUCLA2
EVEXSUCLA2
GoPubMedSUCLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Dec 5 17:30:44 CET 2020
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