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SUCLA2 (succinate-CoA ligase ADP-forming beta subunit)

Identity

Alias_namessuccinate-CoA ligase, ADP-forming, beta subunit
Other aliasA-BETA
A-SCS
MTDPS5
SCS-betaA
HGNC (Hugo) SUCLA2
LocusID (NCBI) 8803
Atlas_Id 74351
Location 13q14.2  [Link to chromosome band 13q14]
Location_base_pair Starts at 47942656 and ends at 48001326 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTTNBP2NL (1p13.2) / SUCLA2 (13q14.2)SUCLA2 (13q14.2) / CASR (3q21.1)SUCLA2 (13q14.2) / FAAP20 (1p36.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SUCLA2   11448
Cards
Entrez_Gene (NCBI)SUCLA2  8803  succinate-CoA ligase ADP-forming beta subunit
AliasesA-BETA; A-SCS; MTDPS5; SCS-betaA
GeneCards (Weizmann)SUCLA2
Ensembl hg19 (Hinxton)ENSG00000136143 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136143 [Gene_View]  ENSG00000136143 [Sequence]  chr13:47942656-48001326 [Contig_View]  SUCLA2 [Vega]
ICGC DataPortalENSG00000136143
TCGA cBioPortalSUCLA2
AceView (NCBI)SUCLA2
Genatlas (Paris)SUCLA2
WikiGenes8803
SOURCE (Princeton)SUCLA2
Genetics Home Reference (NIH)SUCLA2
Genomic and cartography
GoldenPath hg38 (UCSC)SUCLA2  -     chr13:47942656-48001326 -  13q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUCLA2  -     13q14.2   [Description]    (hg19-Feb_2009)
SUCLA2 - 13q14.2 [CytoView hg19]  SUCLA2 - 13q14.2 [CytoView hg38]
Mapping of homologs : NCBISUCLA2 [Mapview hg19]  SUCLA2 [Mapview hg38]
OMIM603921   612073   
Gene and transcription
Genbank (Entrez)AB035863 AF058953 AF087890 AK001458 AK001847
RefSeq transcript (Entrez)NM_003850
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUCLA2
Cluster EST : UnigeneHs.743361 [ NCBI ]
CGAP (NCI)Hs.743361
Alternative Splicing GalleryENSG00000136143
Gene ExpressionSUCLA2 [ NCBI-GEO ]   SUCLA2 [ EBI - ARRAY_EXPRESS ]   SUCLA2 [ SEEK ]   SUCLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)SUCLA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8803
GTEX Portal (Tissue expression)SUCLA2
Human Protein AtlasENSG00000136143-SUCLA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9P2R7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9P2R7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9P2R7
Splice isoforms : SwissVarQ9P2R7
PhosPhoSitePlusQ9P2R7
Domaine pattern : Prosite (Expaxy)ATP_GRASP (PS50975)    SUCCINYL_COA_LIG_3 (PS01217)   
Domains : Interpro (EBI)ATP-grasp    ATP-grasp_succ-CoA_synth-type    ATP_grasp_subdomain_1    ATP_grasp_subdomain_2    CoA_ligase    Succ-CoA_synthase_bsu_CS    Succ_CoA_synthase_bsu    Succinyl-CoA_synth-like   
Domain families : Pfam (Sanger)ATP-grasp_2 (PF08442)    Ligase_CoA (PF00549)   
Domain families : Pfam (NCBI)pfam08442    pfam00549   
Conserved Domain (NCBI)SUCLA2
DMDM Disease mutations8803
Blocks (Seattle)SUCLA2
SuperfamilyQ9P2R7
Human Protein Atlas [tissue]ENSG00000136143-SUCLA2 [tissue]
Peptide AtlasQ9P2R7
HPRD06798
IPIIPI00464979   IPI00217232   IPI01013225   IPI01013597   IPI00513883   IPI00514217   
Protein Interaction databases
DIP (DOE-UCLA)Q9P2R7
IntAct (EBI)Q9P2R7
FunCoupENSG00000136143
BioGRIDSUCLA2
STRING (EMBL)SUCLA2
ZODIACSUCLA2
Ontologies - Pathways
QuickGOQ9P2R7
Ontology : AmiGOsuccinate-CoA ligase (ADP-forming) activity  protein binding  ATP binding  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  succinyl-CoA metabolic process  succinate metabolic process  succinyl-CoA pathway  myelin sheath  metal ion binding  extracellular exosome  
Ontology : EGO-EBIsuccinate-CoA ligase (ADP-forming) activity  protein binding  ATP binding  mitochondrion  mitochondrial matrix  tricarboxylic acid cycle  tricarboxylic acid cycle  succinyl-CoA metabolic process  succinate metabolic process  succinyl-CoA pathway  myelin sheath  metal ion binding  extracellular exosome  
Pathways : KEGGC5-Branched dibasic acid metabolism    Propanoate metabolism    Citrate cycle (TCA cycle)    Reductive carboxylate cycle (CO2 fixation)   
NDEx NetworkSUCLA2
Atlas of Cancer Signalling NetworkSUCLA2
Wikipedia pathwaysSUCLA2
Orthology - Evolution
OrthoDB8803
GeneTree (enSembl)ENSG00000136143
Phylogenetic Trees/Animal Genes : TreeFamSUCLA2
HOGENOMQ9P2R7
Homologs : HomoloGeneSUCLA2
Homology/Alignments : Family Browser (UCSC)SUCLA2
Gene fusions - Rearrangements
Fusion : QuiverSUCLA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUCLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUCLA2
dbVarSUCLA2
ClinVarSUCLA2
1000_GenomesSUCLA2 
Exome Variant ServerSUCLA2
ExAC (Exome Aggregation Consortium)ENSG00000136143
GNOMAD BrowserENSG00000136143
Varsome BrowserSUCLA2
Genetic variants : HAPMAP8803
Genomic Variants (DGV)SUCLA2 [DGVbeta]
DECIPHERSUCLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUCLA2 
Mutations
ICGC Data PortalSUCLA2 
TCGA Data PortalSUCLA2 
Broad Tumor PortalSUCLA2
OASIS PortalSUCLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUCLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUCLA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SUCLA2
DgiDB (Drug Gene Interaction Database)SUCLA2
DoCM (Curated mutations)SUCLA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUCLA2 (select a term)
intoGenSUCLA2
Cancer3DSUCLA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603921    612073   
Orphanet491   
DisGeNETSUCLA2
MedgenSUCLA2
Genetic Testing Registry SUCLA2
NextProtQ9P2R7 [Medical]
TSGene8803
GENETestsSUCLA2
Target ValidationSUCLA2
Huge Navigator SUCLA2 [HugePedia]
snp3D : Map Gene to Disease8803
BioCentury BCIQSUCLA2
ClinGenSUCLA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8803
Chemical/Pharm GKB GenePA36245
Clinical trialSUCLA2
Miscellaneous
canSAR (ICR)SUCLA2 (select the gene name)
DataMed IndexSUCLA2
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUCLA2
EVEXSUCLA2
GoPubMedSUCLA2
iHOPSUCLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Apr 30 13:58:53 CEST 2019
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