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SUCLG1 (succinate-CoA ligase alpha subunit)

Identity

Alias_namessuccinate-CoA ligase, GDP-forming, alpha subunit
succinate-CoA ligase, alpha subunit
Other aliasGALPHA
MTDPS9
SUCLA1
HGNC (Hugo) SUCLG1
LocusID (NCBI) 8802
Atlas_Id 74353
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 84423523 and ends at 84459462 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SP100 (2q37.1) / SUCLG1 (2p11.2)SUCLG1 (2p11.2) / SUCLG1 (2p11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUCLG1   11449
Cards
Entrez_Gene (NCBI)SUCLG1  8802  succinate-CoA ligase alpha subunit
AliasesGALPHA; MTDPS9; SUCLA1
GeneCards (Weizmann)SUCLG1
Ensembl hg19 (Hinxton)ENSG00000163541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163541 [Gene_View]  chr2:84423523-84459462 [Contig_View]  SUCLG1 [Vega]
ICGC DataPortalENSG00000163541
TCGA cBioPortalSUCLG1
AceView (NCBI)SUCLG1
Genatlas (Paris)SUCLG1
WikiGenes8802
SOURCE (Princeton)SUCLG1
Genetics Home Reference (NIH)SUCLG1
Genomic and cartography
GoldenPath hg38 (UCSC)SUCLG1  -     chr2:84423523-84459462 -  2p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUCLG1  -     2p11.2   [Description]    (hg19-Feb_2009)
EnsemblSUCLG1 - 2p11.2 [CytoView hg19]  SUCLG1 - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBISUCLG1 [Mapview hg19]  SUCLG1 [Mapview hg38]
OMIM245400   611224   
Gene and transcription
Genbank (Entrez)AA705613 AF104921 AK024767 AK125502 AK225737
RefSeq transcript (Entrez)NM_003849
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUCLG1
Cluster EST : UnigeneHs.270428 [ NCBI ]
CGAP (NCI)Hs.270428
Alternative Splicing GalleryENSG00000163541
Gene ExpressionSUCLG1 [ NCBI-GEO ]   SUCLG1 [ EBI - ARRAY_EXPRESS ]   SUCLG1 [ SEEK ]   SUCLG1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUCLG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8802
GTEX Portal (Tissue expression)SUCLG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53597   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53597  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53597
Splice isoforms : SwissVarP53597
PhosPhoSitePlusP53597
Domaine pattern : Prosite (Expaxy)SUCCINYL_COA_LIG_1 (PS01216)    SUCCINYL_COA_LIG_2 (PS00399)   
Domains : Interpro (EBI)Cit_synth/succinyl-CoA_lig_AS    Citrt_syn/SCS-alpha_CS    CoA-bd    CoA_lig_alpha    CoA_ligase    NAD(P)-bd_dom    Succinyl-CoA_synth-like   
Domain families : Pfam (Sanger)CoA_binding (PF02629)    Ligase_CoA (PF00549)   
Domain families : Pfam (NCBI)pfam02629    pfam00549   
Domain families : Smart (EMBL)CoA_binding (SM00881)  
Conserved Domain (NCBI)SUCLG1
DMDM Disease mutations8802
Blocks (Seattle)SUCLG1
SuperfamilyP53597
Human Protein AtlasENSG00000163541
Peptide AtlasP53597
HPRD18128
IPIIPI00872762   IPI00916453   IPI00916298   
Protein Interaction databases
DIP (DOE-UCLA)P53597
IntAct (EBI)P53597
FunCoupENSG00000163541
BioGRIDSUCLG1
STRING (EMBL)SUCLG1
ZODIACSUCLG1
Ontologies - Pathways
QuickGOP53597
Ontology : AmiGOnucleotide binding  RNA binding  succinate-CoA ligase (ADP-forming) activity  succinate-CoA ligase (GDP-forming) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  plasma membrane  tricarboxylic acid cycle  tricarboxylic acid cycle  cofactor binding  extracellular exosome  
Ontology : EGO-EBInucleotide binding  RNA binding  succinate-CoA ligase (ADP-forming) activity  succinate-CoA ligase (GDP-forming) activity  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  cytosol  plasma membrane  tricarboxylic acid cycle  tricarboxylic acid cycle  cofactor binding  extracellular exosome  
Pathways : KEGGCitrate cycle (TCA cycle)    Propanoate metabolism   
NDEx NetworkSUCLG1
Atlas of Cancer Signalling NetworkSUCLG1
Wikipedia pathwaysSUCLG1
Orthology - Evolution
OrthoDB8802
GeneTree (enSembl)ENSG00000163541
Phylogenetic Trees/Animal Genes : TreeFamSUCLG1
HOVERGENP53597
HOGENOMP53597
Homologs : HomoloGeneSUCLG1
Homology/Alignments : Family Browser (UCSC)SUCLG1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUCLG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUCLG1
dbVarSUCLG1
ClinVarSUCLG1
1000_GenomesSUCLG1 
Exome Variant ServerSUCLG1
ExAC (Exome Aggregation Consortium)SUCLG1 (select the gene name)
Genetic variants : HAPMAP8802
Genomic Variants (DGV)SUCLG1 [DGVbeta]
DECIPHERSUCLG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUCLG1 
Mutations
ICGC Data PortalSUCLG1 
TCGA Data PortalSUCLG1 
Broad Tumor PortalSUCLG1
OASIS PortalSUCLG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUCLG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUCLG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SUCLG1
DgiDB (Drug Gene Interaction Database)SUCLG1
DoCM (Curated mutations)SUCLG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUCLG1 (select a term)
intoGenSUCLG1
Cancer3DSUCLG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM245400    611224   
Orphanet776   
MedgenSUCLG1
Genetic Testing Registry SUCLG1
NextProtP53597 [Medical]
TSGene8802
GENETestsSUCLG1
Target ValidationSUCLG1
Huge Navigator SUCLG1 [HugePedia]
snp3D : Map Gene to Disease8802
BioCentury BCIQSUCLG1
ClinGenSUCLG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8802
Chemical/Pharm GKB GenePA36246
Clinical trialSUCLG1
Miscellaneous
canSAR (ICR)SUCLG1 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUCLG1
EVEXSUCLG1
GoPubMedSUCLG1
iHOPSUCLG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:44:30 CEST 2017

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