SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)

2018-07-01  

Identity

HGNC
LOCATION
3p14.1
LOCUSID
ALIAS
G-SCS,GBETA,GTPSCS
FUSION GENES

Other Information

Locus ID:

NCBI: 8801
MIM: 603922
HGNC: 11450
Ensembl: ENSG00000172340

Variants:

dbSNP: 8801
ClinVar: 8801
TCGA: ENSG00000172340
COSMIC: SUCLG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172340ENST00000307227Q96I99
ENSG00000172340ENST00000307227A0A024R325
ENSG00000172340ENST00000460567H0Y852
ENSG00000172340ENST00000492795E9PDQ8
ENSG00000172340ENST00000493112Q96I99

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Propanoate metabolismKEGGko00640
Citrate cycle (TCA cycle)KEGGhsa00020
Propanoate metabolismKEGGhsa00640
Metabolic pathwaysKEGGhsa01100
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGhsa_M00011
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetateKEGGM00011
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212951392011The interplay between SUCLA2, SUCLG2, and mitochondrial DNA depletion.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
250273202014SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.15
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
201610662009A Fast Implementation of a Scan Statistic for Identifying Chromosomal Patterns of Genome Wide Association Studies.4
253704872015Localization of SUCLA2 and SUCLG2 subunits of succinyl CoA ligase within the cerebral cortex suggests the absence of matrix substrate-level phosphorylation in glial cells of the human brain.3
287099332017Identification of novel biomarker and therapeutic target candidates for diagnosis and treatment of follicular carcinoma.1

Citation

Dessen P

SUCLG2 (succinate-CoA ligase GDP-forming subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57513/suclg2