SUCNR1 (succinate receptor 1)

2016-10-01  

Identity

HGNC
LOCATION
3q25.1
LOCUSID
ALIAS
GPR91
FUSION GENES

Other Information

Locus ID:

NCBI: 56670
MIM: 606381
HGNC: 4542
Ensembl: ENSG00000198829

Variants:

dbSNP: 56670
ClinVar: 56670
TCGA: ENSG00000198829
COSMIC: SUCNR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198829ENST00000362032Q9BXA5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
151412132004Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.217
151412132004Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.217
274811322016GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis.73
255399792014Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation.25
192041472009The role of the GPR91 ligand succinate in hematopoiesis.23
280614582017Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation.22
267590542016GPR91: expanding the frontiers of Krebs cycle intermediates.20
260512742015Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells.19
283823822017SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes.18
237700962013Succinate receptor GPR91, a Gα(i) coupled receptor that increases intracellular calcium concentrations through PLCβ.16

Citation

Dessen P

SUCNR1 (succinate receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56511/sucnr1