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SUFU (SUFU negative regulator of hedgehog signaling)

Identity

Alias_namessuppressor of fused homolog (Drosophila)
Alias_symbol (synonym)SUFUH
SUFUXL
PRO1280
Other alias
HGNC (Hugo) SUFU
LocusID (NCBI) 51684
Atlas_Id 42447
Location 10q24.32  [Link to chromosome band 10q24]
Location_base_pair Starts at 102503962 and ends at 102619463 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNNM2 (10q24.32) / SUFU (10q24.32)FAM13C (10q21.1) / SUFU (10q24.32)PPP6C (9q33.3) / SUFU (10q24.32)
SUFU (10q24.32) / GBF1 (10q24.32)SUFU (10q24.32) / SUFU (10q24.32)SUFU (10q24.32) / ZCCHC24 (10q22.3)
WBP1L (10q24.32) / SUFU (10q24.32)C10orf26 SUFU 10q24.32CNNM2 10q24.32 / SUFU 10q24.32
SUFU 10q24.32 / GBF1 10q24.32SUFU 10q24.32 / ZCCHC24 10q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Cancer prone implicated (Data extracted from papers in the Atlas) [ 2 ]
  Familial nervous system tumour syndromes Naevoid basal cell carcinoma syndrome (NBCS)


External links

Nomenclature
HGNC (Hugo)SUFU   16466
LRG (Locus Reference Genomic)LRG_521
Cards
Entrez_Gene (NCBI)SUFU  51684  SUFU negative regulator of hedgehog signaling
AliasesPRO1280; SUFUH; SUFUXL
GeneCards (Weizmann)SUFU
Ensembl hg19 (Hinxton)ENSG00000107882 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107882 [Gene_View]  chr10:102503962-102619463 [Contig_View]  SUFU [Vega]
ICGC DataPortalENSG00000107882
TCGA cBioPortalSUFU
AceView (NCBI)SUFU
Genatlas (Paris)SUFU
WikiGenes51684
SOURCE (Princeton)SUFU
Genetics Home Reference (NIH)SUFU
Genomic and cartography
GoldenPath hg38 (UCSC)SUFU  -     chr10:102503962-102619463 +  10q24.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUFU  -     10q24.32   [Description]    (hg19-Feb_2009)
EnsemblSUFU - 10q24.32 [CytoView hg19]  SUFU - 10q24.32 [CytoView hg38]
Mapping of homologs : NCBISUFU [Mapview hg19]  SUFU [Mapview hg38]
OMIM109400   155255   607035   607174   
Gene and transcription
Genbank (Entrez)AF144231 AF159447 AF172319 AF175770 AF222345
RefSeq transcript (Entrez)NM_001178133 NM_016169
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUFU
Cluster EST : UnigeneHs.404089 [ NCBI ]
CGAP (NCI)Hs.404089
Alternative Splicing GalleryENSG00000107882
Gene ExpressionSUFU [ NCBI-GEO ]   SUFU [ EBI - ARRAY_EXPRESS ]   SUFU [ SEEK ]   SUFU [ MEM ]
Gene Expression Viewer (FireBrowse)SUFU [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51684
GTEX Portal (Tissue expression)SUFU
Human Protein AtlasENSG00000107882-SUFU [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMX1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMX1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMX1
Splice isoforms : SwissVarQ9UMX1
PhosPhoSitePlusQ9UMX1
Domains : Interpro (EBI)SUFU-like_domain    SUFU_C    Suppressor_of_fused    Suppressor_of_fused_euk   
Domain families : Pfam (Sanger)SUFU (PF05076)  nbsp+ ĽA HREF=http://pfam.xfam.org/family/PF12470 TARGET=PFAM>SUFU_C (PF12470)   
Domain families : Pfam (NCBI)pfam05076    pfam12470   
Conserved Domain (NCBI)SUFU
DMDM Disease mutations51684
Blocks (Seattle)SUFU
PDB (SRS)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
PDB (PDBSum)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
PDB (IMB)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
PDB (RSDB)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
Structural Biology KnowledgeBase1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
SCOP (Structural Classification of Proteins)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
CATH (Classification of proteins structures)1M1L    4BL8    4BL9    4BLA    4BLB    4BLD    4KM8    4KM9    4KMD    4KMH   
SuperfamilyQ9UMX1
Human Protein Atlas [tissue]ENSG00000107882-SUFU [tissue]
Peptide AtlasQ9UMX1
HPRD06124
IPIIPI00099179   IPI00556458   IPI00556521   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMX1
IntAct (EBI)Q9UMX1
FunCoupENSG00000107882
BioGRIDSUFU
STRING (EMBL)SUFU
ZODIACSUFU
Ontologies - Pathways
QuickGOQ9UMX1
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  skeletal system development  neural tube closure  heart looping  ventricular septum development  transcription corepressor activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  proteolysis  signal transduction  multicellular organism development  beta-catenin binding  transcription factor binding  protein kinase binding  smoothened signaling pathway involved in ventral spinal cord interneuron specification  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  aorta development  negative regulation of transcription factor import into nucleus  cytoplasmic sequestering of transcription factor  negative regulation of sequence-specific DNA binding transcription factor activity  skin development  negative regulation of osteoblast differentiation  negative regulation of smoothened signaling pathway  coronary vasculature development  ciliary tip  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  skeletal system development  neural tube closure  heart looping  ventricular septum development  transcription corepressor activity  signal transducer activity  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  regulation of transcription, DNA-templated  proteolysis  signal transduction  multicellular organism development  beta-catenin binding  transcription factor binding  protein kinase binding  smoothened signaling pathway involved in ventral spinal cord interneuron specification  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification  aorta development  negative regulation of transcription factor import into nucleus  cytoplasmic sequestering of transcription factor  negative regulation of sequence-specific DNA binding transcription factor activity  skin development  negative regulation of osteoblast differentiation  negative regulation of smoothened signaling pathway  coronary vasculature development  ciliary tip  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  
Pathways : BIOCARTASonic Hedgehog (Shh) Pathway [Genes]   
Pathways : KEGGHedgehog signaling pathway    Pathways in cancer    Basal cell carcinoma   
NDEx NetworkSUFU
Atlas of Cancer Signalling NetworkSUFU
Wikipedia pathwaysSUFU
Orthology - Evolution
OrthoDB51684
GeneTree (enSembl)ENSG00000107882
Phylogenetic Trees/Animal Genes : TreeFamSUFU
HOVERGENQ9UMX1
HOGENOMQ9UMX1
Homologs : HomoloGeneSUFU
Homology/Alignments : Family Browser (UCSC)SUFU
Gene fusions - Rearrangements
Fusion : MitelmanCNNM2/SUFU [10q24.32/10q24.32]  [t(10;10)(q24;q24)]  
Fusion : MitelmanFAM13C/SUFU [10q21.1/10q24.32]  [t(10;10)(q21;q24)]  
Fusion : MitelmanSUFU/GBF1 [10q24.32/10q24.32]  [t(10;10)(q24;q24)]  
Fusion : MitelmanSUFU/ZCCHC24 [10q24.32/10q22.3]  [t(10;10)(q22;q24)]  
Fusion : MitelmanWBP1L/SUFU [10q24.32/10q24.32]  [t(10;10)(q24;q24)]  
Fusion: TCGAC10orf26 SUFU 10q24.32 GBM LUAD
Fusion: TCGACNNM2 10q24.32 SUFU 10q24.32 BRCA
Fusion: TCGASUFU 10q24.32 GBF1 10q24.32 BRCA
Fusion: TCGASUFU 10q24.32 ZCCHC24 10q22.3 LGG
Fusion: Tumor Portal SUFU
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUFU [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUFU
dbVarSUFU
ClinVarSUFU
1000_GenomesSUFU 
Exome Variant ServerSUFU
ExAC (Exome Aggregation Consortium)ENSG00000107882
GNOMAD BrowserENSG00000107882
Genetic variants : HAPMAP51684
Genomic Variants (DGV)SUFU [DGVbeta]
DECIPHERSUFU [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUFU 
Mutations
ICGC Data PortalSUFU 
TCGA Data PortalSUFU 
Broad Tumor PortalSUFU
OASIS PortalSUFU [ Somatic mutations - Copy number]
Cancer Gene: CensusSUFU 
Somatic Mutations in Cancer : COSMICSUFU  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUFU
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUFU
DgiDB (Drug Gene Interaction Database)SUFU
DoCM (Curated mutations)SUFU (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUFU (select a term)
intoGenSUFU
Cancer3DSUFU(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109400    155255    607035    607174   
Orphanet207    19682    19681    20073   
MedgenSUFU
Genetic Testing Registry SUFU
NextProtQ9UMX1 [Medical]
TSGene51684
GENETestsSUFU
Target ValidationSUFU
Huge Navigator SUFU [HugePedia]
snp3D : Map Gene to Disease51684
BioCentury BCIQSUFU
ClinGenSUFU
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51684
Chemical/Pharm GKB GenePA38146
Clinical trialSUFU
Miscellaneous
canSAR (ICR)SUFU (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUFU
EVEXSUFU
GoPubMedSUFU
iHOPSUFU
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:13:19 CET 2017

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