SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)

2010-10-01  

Identity

HGNC
LOCATION
13q14.3
LOCUSID
ALIAS
SGT1
FUSION GENES

Other Information

Locus ID:

NCBI: 10910
MIM: 604098
HGNC: 16987
Ensembl: ENSG00000165416

Variants:

dbSNP: 10910
ClinVar: 10910
TCGA: ENSG00000165416
COSMIC: SUGT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165416ENST00000310528Q9Y2Z0
ENSG00000165416ENST00000343788Q9Y2Z0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysREACTOMER-HSA-168643
InflammasomesREACTOMER-HSA-622312
The NLRP3 inflammasomeREACTOMER-HSA-844456

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348276722021Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.2
348276722021Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.2
325140482020SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.6
325140482020SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.6
306569092018Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.10
306569092018Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.10
286962592017Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.3
288165742017SGT1-HSP90 complex is required for CENP-A deposition at centromeres.9
286962592017Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.3
288165742017SGT1-HSP90 complex is required for CENP-A deposition at centromeres.9
275918992016Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli.3
275918992016Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli.3
265457992015Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.6
265457992015Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.6
231849432013Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.9

Citation

Dessen P

SUGT1 (SGT1 homolog, MIS12 kinetochore complex assembly cochaperone)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51737/sugt1