SULT1A3 (sulfotransferase family 1A member 3)

2016-10-01 Affiliation

Identity

HGNC

SULT1A3

LOCATION

16p11.2

LOCUSID

6818

ALIAS

HAST,HAST3,M-PST,ST1A3,ST1A3/ST1A4,ST1A4,ST1A5,STM,TL-PST

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6818
MIM: 600641
HGNC: 11455
Ensembl: ENSG00000261052

Variants:

dbSNP: 6818
ClinVar: 6818
TCGA: ENSG00000261052
COSMIC: SULT1A3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000261052	ENST00000338971	P0DMM9
ENSG00000261052	ENST00000338971	Q1ET61
ENSG00000261052	ENST00000395138	P0DMM9
ENSG00000261052	ENST00000395138	Q1ET61
ENSG00000261052	ENST00000563322	P0DMM9
ENSG00000261052	ENST00000563638	H3BRT0
ENSG00000261052	ENST00000569485	H3BPL6

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism of proteins	REACTOME	R-HSA-392499
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Cytosolic sulfonation of small molecules	REACTOME	R-HSA-156584

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PMIDs
PA166131379	o-desmethyl-tramadol	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK
PA166179720	tapentadol	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PK
PA448015	acetaminophen	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation, Pathway, VariantAnnotation	associated	PK	23462933, 26049587
PA450550	morphine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PK
PA451735	tramadol	Chemical	ClinicalAnnotation	associated	PK

References

Pubmed ID	Year	Title	Citations
16083857	2005	Crystal structure of human sulfotransferase SULT1A3 in complex with dopamine and 3'-phosphoadenosine 5'-phosphate.	18
14871892	2004	Active site mutations and substrate inhibition in human sulfotransferase 1A1 and 1A3.	17
15358107	2004	Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies.	15
14622112	2003	Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism.	13
22949271	2014	Proteomic profiling of osteosarcoma cells identifies ALDOA and SULT1A3 as negative survival markers of human osteosarcoma.	11
26067475	2015	Sulphation of acetaminophen by the human cytosolic sulfotransferases: a systematic analysis.	8
22352375	2012	SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.	7
25941087	2015	Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism.	7
19447296	2009	Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells.	5
28630292	2017	Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.	5

Citation

Dessen P

SULT1A3 (sulfotransferase family 1A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56490/sult1a3