SULT1A4 (sulfotransferase family 1A member 4)

2014-11-01  

Identity

HGNC
SULT1A4
LOCATION
16p11.2
LOCUSID
445329
ALIAS
HAST3,M-PST,ST1A3,ST1A3/ST1A4,ST1A4,STM,TL-PST

Other Information

Locus ID:

NCBI: 445329
MIM: 615819
HGNC: 30004
Ensembl: ENSG00000213648

Variants:

dbSNP: 445329
ClinVar: 445329
TCGA: ENSG00000213648
COSMIC: SULT1A4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213648ENST00000360423P0DMN0
ENSG00000213648ENST00000360423Q1ET61
ENSG00000213648ENST00000563944H3BRT0
ENSG00000213648ENST00000565290A0A0A6YYL2
ENSG00000213648ENST00000569544H3BNY7

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448015acetaminophenChemicalClinicalAnnotation, PathwayassociatedPK26049587
PA450550morphineChemicalClinicalAnnotationassociatedPK

References

Pubmed IDYearTitleCitations
297052712018Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.2
311457022019Impact of SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of phenylephrine and salbutamol by human SULT1A3 allozymes.0

Citation

Dessen P

SULT1A4 (sulfotransferase family 1A member 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74363/sult1a4