SULT2A1 (sulfotransferase family 2A member 1)

2007-02-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
DHEA-ST,DHEA-ST8,DHEAS,HST,ST2,ST2A1,ST2A3,STD,SULT2A3,hSTa
FUSION GENES

Other Information

Locus ID:

NCBI: 6822
MIM: 125263
HGNC: 11458
Ensembl: ENSG00000105398

Variants:

dbSNP: 6822
ClinVar: 6822
TCGA: ENSG00000105398
COSMIC: SULT2A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105398ENST00000222002Q06520
ENSG00000105398ENST00000222002A8K015

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA31751NR1H3GeneMultilinkAnnotationassociated26555224
PA448015acetaminophenChemicalPathwayassociated26049587

References

Pubmed IDYearTitleCitations
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
232567512013The gate that governs sulfotransferase selectivity.31
119880892002Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate.26
250569522014Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1.18
153887882005Steroid sulfotransferase 2A1 gene transcription is regulated by steroidogenic factor 1 and GATA-6 in the human adrenal.17
158789682005Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha.15
180427342008Identification and characterization of two amino acids critical for the substrate inhibition of human dehydroepiandrosterone sulfotransferase (SULT2A1).15
233622782013Testing the sulfotransferase molecular pore hypothesis.15
232115252013Regulation of the human hydroxysteroid sulfotransferase (SULT2A1) by RORα and RORγ and its potential relevance to human liver diseases.14
201022952010Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1).13

Citation

Dessen P

SULT2A1 (sulfotransferase family 2A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46236/sult2a1