SULT2B1 (sulfotransferase family 2B member 1)

2008-10-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
ARCI14,HSST2
FUSION GENES

Other Information

Locus ID:

NCBI: 6820
MIM: 604125
HGNC: 11459
Ensembl: ENSG00000088002

Variants:

dbSNP: 6820
ClinVar: 6820
TCGA: ENSG00000088002
COSMIC: SULT2B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000088002ENST00000201586O00204
ENSG00000088002ENST00000323090O00204

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Steroid hormone biosynthesisKEGGhsa00140
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA164749431gemtuzumab ozogamicinChemicalClinicalAnnotationassociatedPD22584460
PA444760Leukemia, Myeloid, AcuteDiseaseClinicalAnnotationassociatedPD22584460
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA449177cytarabineChemicalClinicalAnnotationassociatedPD22584460
PA449655fludarabineChemicalClinicalAnnotationassociatedPD22584460
PA449961idarubicinChemicalClinicalAnnotationassociatedPD22584460

References

Pubmed IDYearTitleCitations
173474982007Oxysterols are substrates for cholesterol sulfotransferase.34
211461702011Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.29
129231822003Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.20
147410472004Different subcellular localization of sulphotransferase 2B1b in human placenta and prostate.20
151402242004Expression of cholesterol sulfotransferase (SULT2B1b) in human skin and primary cultures of human epidermal keratinocytes.18
121453172002Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.17
150637622004Genetic variations in humans associated with differences in the course of hepatitis C.16
235794882013SULT2B1b sulfotransferase: induction by vitamin D receptor and reduced expression in prostate cancer.15
240203832013SULT2B1: unique properties and characteristics of a hydroxysteroid sulfotransferase family.14
158786392005Identification and immunohistochemical localization of Sulfotransferase 2B1b (SULT2B1b) in human lung.13

Citation

Dessen P

SULT2B1 (sulfotransferase family 2B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50436/sult2b1