SUMF2 (sulfatase modifying factor 2)

2014-11-01 Affiliation

Identity

HGNC

SUMF2

LOCATION

7p11.2

LOCUSID

25870

ALIAS

pFGE

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 25870
MIM: 607940
HGNC: 20415
Ensembl: ENSG00000129103

Variants:

dbSNP: 25870
ClinVar: 25870
TCGA: ENSG00000129103
COSMIC: SUMF2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000129103	ENST00000275607	Q8NBJ7
ENSG00000129103	ENST00000275607	A0A024RDK8
ENSG00000129103	ENST00000342190	Q8NBJ7
ENSG00000129103	ENST00000395435	Q8NBJ7
ENSG00000129103	ENST00000395436	A8MXB9
ENSG00000129103	ENST00000413756	C9J660
ENSG00000129103	ENST00000413952	C9JL30
ENSG00000129103	ENST00000423763	F8WEX5
ENSG00000129103	ENST00000434526	Q8NBJ7
ENSG00000129103	ENST00000436782	F8WEV7
ENSG00000129103	ENST00000437307	E9PBT8
ENSG00000129103	ENST00000438133	F8WES7
ENSG00000129103	ENST00000447501	E9PG02
ENSG00000129103	ENST00000451338	H7C3B2
ENSG00000129103	ENST00000452216	F8WCW9
ENSG00000129103	ENST00000650735	J3QT17
ENSG00000129103	ENST00000651354	J3KQJ1
ENSG00000129103	ENST00000651586	A0A494C1B1
ENSG00000129103	ENST00000652303	F8WA42

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Gamma carboxylation, hypusine formation and arylsulfatase activation	REACTOME	R-HSA-163841
The activation of arylsulfatases	REACTOME	R-HSA-1663150
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Glycosphingolipid metabolism	REACTOME	R-HSA-1660662

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15962010	2005	Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2.	11
15687489	2005	Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme.	8
15708861	2005	Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme.	5
18266766	2008	Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals.	5
19739097	2009	SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells.	4

Citation

Dessen P

SUMF2 (sulfatase modifying factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/74372/sumf2