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SUMO1 (small ubiquitin like modifier 1)

Identity

Alias (NCBI)DAP1
GMP1
OFC10
PIC1
SENP2
SMT3
SMT3C
SMT3H3
UBL1
HGNC (Hugo) SUMO1
HGNC Alias symbPIC1
GMP1
SMT3C
SUMO-1
SMT3H3
OFC10
HGNC Previous nameUBL1
HGNC Previous nameubiquitin-like 1 (sentrin)
 SMT3 suppressor of mif two 3 homolog 1 (yeast)
 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)
LocusID (NCBI) 7341
Atlas_Id 42758
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 202206185 and ends at 202238597 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SPCS2 (11q13.4) / SUMO1 (2q33.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)SUMO1   12502
Cards
Entrez_Gene (NCBI)SUMO1    small ubiquitin like modifier 1
AliasesDAP1; GMP1; OFC10; PIC1; 
SENP2; SMT3; SMT3C; SMT3H3; UBL1
GeneCards (Weizmann)SUMO1
Ensembl hg19 (Hinxton)ENSG00000116030 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116030 [Gene_View]  ENSG00000116030 [Sequence]  chr2:202206185-202238597 [Contig_View]  SUMO1 [Vega]
ICGC DataPortalENSG00000116030
TCGA cBioPortalSUMO1
AceView (NCBI)SUMO1
Genatlas (Paris)SUMO1
SOURCE (Princeton)SUMO1
Genetics Home Reference (NIH)SUMO1
Genomic and cartography
GoldenPath hg38 (UCSC)SUMO1  -     chr2:202206185-202238597 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUMO1  -     2q33.1   [Description]    (hg19-Feb_2009)
GoldenPathSUMO1 - 2q33.1 [CytoView hg19]  SUMO1 - 2q33.1 [CytoView hg38]
ImmunoBaseENSG00000116030
genome Data Viewer NCBISUMO1 [Mapview hg19]  
OMIM601912   613705   
Gene and transcription
Genbank (Entrez)AA401634 AB062294 AI815216 AK311840 BC005899
RefSeq transcript (Entrez)NM_001005781 NM_001005782 NM_001371392 NM_001371393 NM_001371394 NM_003352
Consensus coding sequences : CCDS (NCBI)SUMO1
Alternative Splicing GalleryENSG00000116030
Gene ExpressionSUMO1 [ NCBI-GEO ]   SUMO1 [ EBI - ARRAY_EXPRESS ]   SUMO1 [ SEEK ]   SUMO1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUMO1 [ Firebrowse - Broad ]
GenevisibleExpression of SUMO1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7341
GTEX Portal (Tissue expression)SUMO1
Human Protein AtlasENSG00000116030-SUMO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63165   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63165  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63165
PhosPhoSitePlusP63165
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Rad60/SUMO-like_dom    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)Rad60-SLD (PF11976)   
Domain families : Pfam (NCBI)pfam11976   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)SUMO1
PDB (RSDB)1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
PDB Europe1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
PDB (PDBSum)1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
PDB (IMB)1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
Structural Biology KnowledgeBase1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
SCOP (Structural Classification of Proteins)1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
CATH (Classification of proteins structures)1A5R    1TGZ    1WYW    1Y8R    1Z5S    2ASQ    2BF8    2G4D    2IO2    2IY0    2IY1    2KQS    2LAS    2MW5    2N1A    2N1V    2PE6    2UYZ    2VRR    3KYC    3KYD    3RZW    3UIP    4WJN    4WJO    4WJP    4WJQ    5AEK    5B7A    5ELJ    5GHD    6EOP    6EOT    6J4I    6JXU    6JXV    6K5T    6UYO    6UYP    6UYQ    6UYR    6UYS    6UYT    6UYU    6UYV    6UYX    6UYY    6UYZ    6V7P    6V7Q    6V7R    6V7S    6WW3   
SuperfamilyP63165
AlphaFold pdb e-kbP63165   
Human Protein Atlas [tissue]ENSG00000116030-SUMO1 [tissue]
HPRD03554
Protein Interaction databases
DIP (DOE-UCLA)P63165
IntAct (EBI)P63165
BioGRIDSUMO1
STRING (EMBL)SUMO1
ZODIACSUMO1
Ontologies - Pathways
QuickGOP63165
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA binding  protein binding  nucleus  nucleus  nucleus  nuclear envelope  nuclear pore  nucleoplasm  nucleoplasm  nucleolus  cytosol  plasma membrane  DNA repair  double-strand break repair  double-strand break repair via nonhomologous end joining  mitotic nuclear membrane reassembly  transcription factor binding  potassium channel regulator activity  nuclear body  PML body  PML body  PML body  nuclear speck  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  viral protein processing  enzyme binding  positive regulation of protein-containing complex assembly  protein tag  ubiquitin protein ligase binding  nuclear membrane  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  cellular response to heat  negative regulation of DNA binding  negative regulation of DNA binding  negative regulation of DNA-binding transcription factor activity  small protein activating enzyme binding  ubiquitin-like protein ligase binding  negative regulation of action potential  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  protein stabilization  roof of mouth development  regulation of interferon-gamma-mediated signaling pathway  cellular response to cadmium ion  nuclear stress granule  negative regulation of delayed rectifier potassium channel activity  ubiquitin-specific protease binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA binding  protein binding  nucleus  nucleus  nucleus  nuclear envelope  nuclear pore  nucleoplasm  nucleoplasm  nucleolus  cytosol  plasma membrane  DNA repair  double-strand break repair  double-strand break repair via nonhomologous end joining  mitotic nuclear membrane reassembly  transcription factor binding  potassium channel regulator activity  nuclear body  PML body  PML body  PML body  nuclear speck  protein sumoylation  protein sumoylation  protein sumoylation  protein sumoylation  viral protein processing  enzyme binding  positive regulation of protein-containing complex assembly  protein tag  ubiquitin protein ligase binding  nuclear membrane  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  regulation of protein localization  cellular response to heat  negative regulation of DNA binding  negative regulation of DNA binding  negative regulation of DNA-binding transcription factor activity  small protein activating enzyme binding  ubiquitin-like protein ligase binding  negative regulation of action potential  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  protein stabilization  roof of mouth development  regulation of interferon-gamma-mediated signaling pathway  cellular response to cadmium ion  nuclear stress granule  negative regulation of delayed rectifier potassium channel activity  ubiquitin-specific protease binding  
Pathways : BIOCARTARole of Parkin in the Ubiquitin-Proteasomal Pathway [Genes]    Regulation of transcriptional activity by PML [Genes]    SUMOylation as a mechanism to modulate CtBP-dependent gene responses [Genes]    Sumoylation by RanBP2 Regulates Transcriptional Repression [Genes]    Basic Mechanisms of SUMOylation [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkSUMO1
Atlas of Cancer Signalling NetworkSUMO1
Wikipedia pathwaysSUMO1
Orthology - Evolution
OrthoDB7341
GeneTree (enSembl)ENSG00000116030
Phylogenetic Trees/Animal Genes : TreeFamSUMO1
Homologs : HomoloGeneSUMO1
Homology/Alignments : Family Browser (UCSC)SUMO1
Gene fusions - Rearrangements
Fusion : QuiverSUMO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUMO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUMO1
dbVarSUMO1
ClinVarSUMO1
MonarchSUMO1
1000_GenomesSUMO1 
Exome Variant ServerSUMO1
GNOMAD BrowserENSG00000116030
Varsome BrowserSUMO1
Genomic Variants (DGV)SUMO1 [DGVbeta]
DECIPHERSUMO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUMO1 
Mutations
ICGC Data PortalSUMO1 
TCGA Data PortalSUMO1 
Broad Tumor PortalSUMO1
OASIS PortalSUMO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUMO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUMO1
Mutations and Diseases : HGMDSUMO1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch SUMO1
DgiDB (Drug Gene Interaction Database)SUMO1
DoCM (Curated mutations)SUMO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUMO1 (select a term)
Cancer3DSUMO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601912    613705   
Orphanet
DisGeNETSUMO1
MedgenSUMO1
Genetic Testing Registry SUMO1
NextProtP63165 [Medical]
GENETestsSUMO1
Target ValidationSUMO1
Huge Navigator SUMO1 [HugePedia]
ClinGenSUMO1
Clinical trials, drugs, therapy
MyCancerGenomeSUMO1
Protein Interactions : CTDSUMO1
Pharm GKB GenePA37149
PharosP63165
Clinical trialSUMO1
Miscellaneous
canSAR (ICR)SUMO1
HarmonizomeSUMO1
DataMed IndexSUMO1
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSUMO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Sep 15 22:39:25 CEST 2021

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