SUMO2 (small ubiquitin like modifier 2)

2010-06-01  

Identity

HGNC
LOCATION
17q25.1
LOCUSID
ALIAS
HSMT3,SMT3B,SMT3H2,SUMO3,Smt3A
FUSION GENES

Other Information

Locus ID:

NCBI: 6613
MIM: 603042
HGNC: 11125
Ensembl: ENSG00000188612

Variants:

dbSNP: 6613
ClinVar: 6613
TCGA: ENSG00000188612
COSMIC: SUMO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188612ENST00000314523P61956
ENSG00000188612ENST00000420826P61956
ENSG00000188612ENST00000420826A0A024R8S3
ENSG00000188612ENST00000578238J3KRH1

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Nuclear pore complexKEGGhsa_M00427
Nuclear pore complexKEGGM00427
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is proteolytically processedREACTOMER-HSA-3065679
SUMO is conjugated to E1 (UBA2:SAE1)REACTOMER-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
SUMOylation of transcription factorsREACTOMER-HSA-3232118
SUMOylation of chromatin organization proteinsREACTOMER-HSA-4551638
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
165248842006Specification of SUMO1- and SUMO2-interacting motifs.198
207976342010Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.122
126655922003Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.107
183746472008SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.101
154569022004Distinct in vivo dynamics of vertebrate SUMO paralogues.91
247825672014Proteome-wide identification of SUMO2 modification sites.77
193942922009Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.75
245825012014Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein.71
187083562008Small ubiquitin-related modifier (SUMO) binding determines substrate recognition and paralog-selective SUMO modification.70
160557102005Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation.69

Citation

Dessen P

SUMO2 (small ubiquitin like modifier 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51516/sumo2