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SUMO2 (small ubiquitin like modifier 2)

Identity

Alias (NCBI)HSMT3
SMT3B
SMT3H2
SUMO3
Smt3A
HGNC (Hugo) SUMO2
HGNC Alias symbSMT3B
HGNC Previous nameSMT3H2
HGNC Previous nameSMT3 (suppressor of mif two 3, yeast) homolog 2
 SMT3 suppressor of mif two 3 homolog 2 (yeast)
 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)
LocusID (NCBI) 6613
Atlas_Id 51516
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75165586 and ends at 75182959 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NUP85 (17q25.1) / SUMO2 (17q25.1)SUMO2 (17q25.1) / MXRA7 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(2)(p23q13) RANBP2/ALK::t(2;2)(p23;q13) RANBP2/ALK


External links

 

Nomenclature
HGNC (Hugo)SUMO2   11125
Cards
Entrez_Gene (NCBI)SUMO2    small ubiquitin like modifier 2
AliasesHSMT3; SMT3B; SMT3H2; SUMO3; 
Smt3A
GeneCards (Weizmann)SUMO2
Ensembl hg19 (Hinxton)ENSG00000188612 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188612 [Gene_View]  ENSG00000188612 [Sequence]  chr17:75165586-75182959 [Contig_View]  SUMO2 [Vega]
ICGC DataPortalENSG00000188612
TCGA cBioPortalSUMO2
AceView (NCBI)SUMO2
Genatlas (Paris)SUMO2
SOURCE (Princeton)SUMO2
Genetics Home Reference (NIH)SUMO2
Genomic and cartography
GoldenPath hg38 (UCSC)SUMO2  -     chr17:75165586-75182959 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUMO2  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathSUMO2 - 17q25.1 [CytoView hg19]  SUMO2 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000188612
Genome Data Viewer NCBISUMO2 [Mapview hg19]  
OMIM603042   
Gene and transcription
Genbank (Entrez)AK024823 AK225090 AK225263 AK311837 BC008450
RefSeq transcript (Entrez)NM_001005849 NM_006937
Consensus coding sequences : CCDS (NCBI)SUMO2
Gene ExpressionSUMO2 [ NCBI-GEO ]   SUMO2 [ EBI - ARRAY_EXPRESS ]   SUMO2 [ SEEK ]   SUMO2 [ MEM ]
Gene Expression Viewer (FireBrowse)SUMO2 [ Firebrowse - Broad ]
GenevisibleExpression of SUMO2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6613
GTEX Portal (Tissue expression)SUMO2
Human Protein AtlasENSG00000188612-SUMO2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61956
PhosPhoSitePlusP61956
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Rad60/SUMO-like_dom    Ubiquitin-like_dom    Ubiquitin-like_domsf   
Domain families : Pfam (Sanger)Rad60-SLD (PF11976)   
Domain families : Pfam (NCBI)pfam11976   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)SUMO2
PDB (RSDB)1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
PDB Europe1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
PDB (PDBSum)1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
PDB (IMB)1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
Structural Biology KnowledgeBase1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
SCOP (Structural Classification of Proteins)1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
CATH (Classification of proteins structures)1WM2    1WM3    1WZ0    1Z5Q    2AWT    2CKH    2D07    2IO0    2IO3    2IYD    2N1W    2N9E    2RPQ    3UIN    3UIO    3ZO5    4BKG    4NPN    5D2M    5ELU    5EQL    5GHB    5GHC    6JXW    6JXX   
SuperfamilyP61956
AlphaFold pdb e-kbP61956   
Human Protein Atlas [tissue]ENSG00000188612-SUMO2 [tissue]
HPRD04332
Protein Interaction databases
DIP (DOE-UCLA)P61956
IntAct (EBI)P61956
BioGRIDSUMO2
STRING (EMBL)SUMO2
ZODIACSUMO2
Ontologies - Pathways
QuickGOP61956
Ontology : AmiGORNA binding  protein binding  nucleus  nucleus  nucleoplasm  PML body  protein sumoylation  protein sumoylation  SUMO transferase activity  protein tag  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-like protein ligase binding  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIRNA binding  protein binding  nucleus  nucleus  nucleoplasm  PML body  protein sumoylation  protein sumoylation  SUMO transferase activity  protein tag  ubiquitin protein ligase binding  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  ubiquitin-like protein ligase binding  positive regulation of transcription by RNA polymerase II  
Pathways : BIOCARTABasic Mechanisms of SUMOylation [Genes]   
Pathways : KEGGRNA transport   
NDEx NetworkSUMO2
Atlas of Cancer Signalling NetworkSUMO2
Wikipedia pathwaysSUMO2
Orthology - Evolution
OrthoDB6613
GeneTree (enSembl)ENSG00000188612
Phylogenetic Trees/Animal Genes : TreeFamSUMO2
Homologs : HomoloGeneSUMO2
Homology/Alignments : Family Browser (UCSC)SUMO2
Gene fusions - Rearrangements
Fusion : QuiverSUMO2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUMO2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUMO2
dbVarSUMO2
ClinVarSUMO2
MonarchSUMO2
1000_GenomesSUMO2 
Exome Variant ServerSUMO2
GNOMAD BrowserENSG00000188612
Varsome BrowserSUMO2
ACMGSUMO2 variants
VarityP61956
Genomic Variants (DGV)SUMO2 [DGVbeta]
DECIPHERSUMO2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUMO2 
Mutations
ICGC Data PortalSUMO2 
TCGA Data PortalSUMO2 
Broad Tumor PortalSUMO2
OASIS PortalSUMO2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUMO2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUMO2
Mutations and Diseases : HGMDSUMO2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSUMO2
DgiDB (Drug Gene Interaction Database)SUMO2
DoCM (Curated mutations)SUMO2
CIViC (Clinical Interpretations of Variants in Cancer)SUMO2
Cancer3DSUMO2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603042   
Orphanet
DisGeNETSUMO2
MedgenSUMO2
Genetic Testing Registry SUMO2
NextProtP61956 [Medical]
GENETestsSUMO2
Target ValidationSUMO2
Huge Navigator SUMO2 [HugePedia]
ClinGenSUMO2
Clinical trials, drugs, therapy
MyCancerGenomeSUMO2
Protein Interactions : CTDSUMO2
Pharm GKB GenePA134914683
PharosP61956
Clinical trialSUMO2
Miscellaneous
canSAR (ICR)SUMO2
HarmonizomeSUMO2
DataMed IndexSUMO2
Probes
Litterature
PubMed241 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSUMO2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:51 CEST 2021

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