SUN1 (Sad1 and UNC84 domain containing 1)

2016-10-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
UNC84A
FUSION GENES

Other Information

Locus ID:

NCBI: 23353
MIM: 607723
HGNC: 18587
Ensembl: ENSG00000164828

Variants:

dbSNP: 23353
ClinVar: 23353
TCGA: ENSG00000164828
COSMIC: SUN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164828ENST00000389574O94901
ENSG00000164828ENST00000401592O94901
ENSG00000164828ENST00000403868O94901
ENSG00000164828ENST00000405266E9PHI4
ENSG00000164828ENST00000419312H7C3X3
ENSG00000164828ENST00000421580C9JS54
ENSG00000164828ENST00000424128C9JR15
ENSG00000164828ENST00000425407O94901
ENSG00000164828ENST00000429178H0Y742
ENSG00000164828ENST00000433212H0Y6N5
ENSG00000164828ENST00000435699C9JK55
ENSG00000164828ENST00000439679C9K051
ENSG00000164828ENST00000440380C9JR15
ENSG00000164828ENST00000450881H7C019
ENSG00000164828ENST00000452783O94901
ENSG00000164828ENST00000457378O94901
ENSG00000164828ENST00000457598C9JJU6
ENSG00000164828ENST00000457861H7C2K3

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160792852005The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.171
103755071999UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.130
199335762010Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.106
225414282012Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies.93
177241192007Functional association of Sun1 with nuclear pore complexes.91
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
252108892014Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
115930022001Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane.61
217271972011POM121 and Sun1 play a role in early steps of interphase NPC assembly.56

Citation

Dessen P

SUN1 (Sad1 and UNC84 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56534/sun1