SUN2 (Sad1 and UNC84 domain containing 2)

2015-05-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
UNC84B,rab5IP
FUSION GENES

Other Information

Locus ID:

NCBI: 25777
MIM: 613569
HGNC: 14210
Ensembl: ENSG00000100242

Variants:

dbSNP: 25777
ClinVar: 25777
TCGA: ENSG00000100242
COSMIC: SUN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100242ENST00000405018Q9UH99
ENSG00000100242ENST00000405510Q9UH99
ENSG00000100242ENST00000405510A0A024R1P7
ENSG00000100242ENST00000406622Q9UH99
ENSG00000100242ENST00000406622A0A024R1P7
ENSG00000100242ENST00000417332B0QY69
ENSG00000100242ENST00000420859B0QY65
ENSG00000100242ENST00000430185H0Y686
ENSG00000100242ENST00000433561B0QY66
ENSG00000100242ENST00000438058B0QY63
ENSG00000100242ENST00000439339B0QY68
ENSG00000100242ENST00000452294B0QY67
ENSG00000100242ENST00000455125B0QY60
ENSG00000100242ENST00000456894B0QY64

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
MeiosisREACTOMER-HSA-1500620
Meiotic synapsisREACTOMER-HSA-1221632

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226329682012LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.154
199335762010Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.106
178273882007Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.67
252108892014Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization.66
221700552012Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.55
201083212010Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.39
205519052010A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane.38
266588022015SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer.31
171320862006Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome.29
246625672014SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.24

Citation

Dessen P

SUN2 (Sad1 and UNC84 domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55222/sun2