SUOX (sulfite oxidase)

2014-05-01 Affiliation

Identity

HGNC

SUOX

LOCATION

12q13.2

LOCUSID

6821

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6821
MIM: 606887
HGNC: 11460
Ensembl: ENSG00000139531

Variants:

dbSNP: 6821
ClinVar: 6821
TCGA: ENSG00000139531
COSMIC: SUOX

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000139531	ENST00000266971	P51687
ENSG00000139531	ENST00000266971	A0A024RB79
ENSG00000139531	ENST00000356124	P51687
ENSG00000139531	ENST00000356124	A0A024RB79
ENSG00000139531	ENST00000394109	P51687
ENSG00000139531	ENST00000394109	A0A024RB79
ENSG00000139531	ENST00000394115	P51687
ENSG00000139531	ENST00000394115	A0A024RB79
ENSG00000139531	ENST00000546833	F8VVW9
ENSG00000139531	ENST00000547586	F8VRK9
ENSG00000139531	ENST00000548274	P51687
ENSG00000139531	ENST00000548274	A0A024RB79
ENSG00000139531	ENST00000550065	P51687
ENSG00000139531	ENST00000550065	A0A024RB79
ENSG00000139531	ENST00000551841	F8VX56
ENSG00000139531	ENST00000552258	F8VPA2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Sulfur metabolism	KEGG	ko00920
Sulfur metabolism	KEGG	hsa00920
Metabolic pathways	KEGG	hsa01100
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Sulfur amino acid metabolism	REACTOME	R-HSA-1614635
Degradation of cysteine and homocysteine	REACTOME	R-HSA-1614558
Sulfide oxidation to sulfate	REACTOME	R-HSA-1614517

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
24106282	2013	Cross-ethnic meta-analysis of genetic variants for polycystic ovary syndrome.	27
23665285	2013	SUOX is a promising diagnostic and prognostic biomarker for hepatocellular carcinoma.	26
18529001	2008	Structural studies of the molybdenum center of the pathogenic R160Q mutant of human sulfite oxidase by pulsed EPR spectroscopy and 17O and 33S labeling.	17
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
25314640	2015	Sulfite Oxidase Catalyzes Single-Electron Transfer at Molybdenum Domain to Reduce Nitrite to Nitric Oxide.	17
14567685	2003	Essential role of conserved arginine 160 in intramolecular electron transfer in human sulfite oxidase.	15
16140720	2005	Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature.	14
14729666	2004	The role of tyrosine 343 in substrate binding and catalysis by human sulfite oxidase.	13
20063894	2010	Effects of interdomain tether length and flexibility on the kinetics of intramolecular electron transfer in human sulfite oxidase.	13
12424234	2003	Role of conserved tyrosine 343 in intramolecular electron transfer in human sulfite oxidase.	11

Citation

Dessen P

SUOX (sulfite oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53894/suox