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SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

Identity

Alias (NCBI)SPT4
SPT4H
SUPT4H
Supt4a
HGNC (Hugo) SUPT4H1
HGNC Alias symbSPT4H
Spt4
Supt4a
HGNC Previous nameSUPT4H
HGNC Previous namesuppressor of Ty (S.cerevisiae) 4 homolog 1
 suppressor of Ty 4 homolog 1 (S. cerevisiae)
LocusID (NCBI) 6827
Atlas_Id 42452
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58345178 and ends at 58352201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SUPT4H1 (17q22) / CEP112 (17q24.1)SUPT4H1 (17q22) / PSMD12 (17q24.2)SUPT4H1 (17q22) / SEPT4 (17q22)
SUPT4H1 17q22 / PSMD12 17q24.2SUPT4H1 17q22 / SEPT4 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)SUPT4H1   11467
Cards
Entrez_Gene (NCBI)SUPT4H1    SPT4 homolog, DSIF elongation factor subunit
AliasesSPT4; SPT4H; SUPT4H; Supt4a
GeneCards (Weizmann)SUPT4H1
Ensembl hg19 (Hinxton)ENSG00000213246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213246 [Gene_View]  ENSG00000213246 [Sequence]  chr17:58345178-58352201 [Contig_View]  SUPT4H1 [Vega]
ICGC DataPortalENSG00000213246
TCGA cBioPortalSUPT4H1
AceView (NCBI)SUPT4H1
Genatlas (Paris)SUPT4H1
SOURCE (Princeton)SUPT4H1
Genetics Home Reference (NIH)SUPT4H1
Genomic and cartography
GoldenPath hg38 (UCSC)SUPT4H1  -     chr17:58345178-58352201 -  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPT4H1  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathSUPT4H1 - 17q22 [CytoView hg19]  SUPT4H1 - 17q22 [CytoView hg38]
ImmunoBaseENSG00000213246
Genome Data Viewer NCBISUPT4H1 [Mapview hg19]  
OMIM603555   
Gene and transcription
Genbank (Entrez)AA311965 AI342302 AI735030 AK129758 AK311986
RefSeq transcript (Entrez)NM_003168
Consensus coding sequences : CCDS (NCBI)SUPT4H1
Gene ExpressionSUPT4H1 [ NCBI-GEO ]   SUPT4H1 [ EBI - ARRAY_EXPRESS ]   SUPT4H1 [ SEEK ]   SUPT4H1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT4H1 [ Firebrowse - Broad ]
GenevisibleExpression of SUPT4H1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6827
GTEX Portal (Tissue expression)SUPT4H1
Human Protein AtlasENSG00000213246-SUPT4H1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63272   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63272  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63272
PhosPhoSitePlusP63272
Domains : Interpro (EBI)RPABC4/Spt4    Spt4    Spt4/RpoE2_Znf    Spt4_sf   
Domain families : Pfam (Sanger)Spt4 (PF06093)   
Domain families : Pfam (NCBI)pfam06093   
Domain families : Smart (EMBL)Spt4 (SM01389)  
Conserved Domain (NCBI)SUPT4H1
PDB (RSDB)3H7H    5OIK    6GMH    6GML    6TED   
PDB Europe3H7H    5OIK    6GMH    6GML    6TED   
PDB (PDBSum)3H7H    5OIK    6GMH    6GML    6TED   
PDB (IMB)3H7H    5OIK    6GMH    6GML    6TED   
Structural Biology KnowledgeBase3H7H    5OIK    6GMH    6GML    6TED   
SCOP (Structural Classification of Proteins)3H7H    5OIK    6GMH    6GML    6TED   
CATH (Classification of proteins structures)3H7H    5OIK    6GMH    6GML    6TED   
SuperfamilyP63272
AlphaFold pdb e-kbP63272   
Human Protein Atlas [tissue]ENSG00000213246-SUPT4H1 [tissue]
HPRD16026
Protein Interaction databases
DIP (DOE-UCLA)P63272
IntAct (EBI)P63272
BioGRIDSUPT4H1
STRING (EMBL)SUPT4H1
ZODIACSUPT4H1
Ontologies - Pathways
QuickGOP63272
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  protein binding  nucleoplasm  nucleoplasm  chromatin organization  regulation of transcription, DNA-templated  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of viral transcription  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  protein binding  nucleoplasm  nucleoplasm  chromatin organization  regulation of transcription, DNA-templated  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of viral transcription  
NDEx NetworkSUPT4H1
Atlas of Cancer Signalling NetworkSUPT4H1
Wikipedia pathwaysSUPT4H1
Orthology - Evolution
OrthoDB6827
GeneTree (enSembl)ENSG00000213246
Phylogenetic Trees/Animal Genes : TreeFamSUPT4H1
Homologs : HomoloGeneSUPT4H1
Homology/Alignments : Family Browser (UCSC)SUPT4H1
Gene fusions - Rearrangements
Fusion : MitelmanSUPT4H1/CEP112 [17q22/17q24.1]  
Fusion : MitelmanSUPT4H1/PSMD12 [17q22/17q24.2]  
Fusion : QuiverSUPT4H1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT4H1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT4H1
dbVarSUPT4H1
ClinVarSUPT4H1
MonarchSUPT4H1
1000_GenomesSUPT4H1 
Exome Variant ServerSUPT4H1
GNOMAD BrowserENSG00000213246
Varsome BrowserSUPT4H1
ACMGSUPT4H1 variants
VarityP63272
Genomic Variants (DGV)SUPT4H1 [DGVbeta]
DECIPHERSUPT4H1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPT4H1 
Mutations
ICGC Data PortalSUPT4H1 
TCGA Data PortalSUPT4H1 
Broad Tumor PortalSUPT4H1
OASIS PortalSUPT4H1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT4H1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUPT4H1
Mutations and Diseases : HGMDSUPT4H1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSUPT4H1
DgiDB (Drug Gene Interaction Database)SUPT4H1
DoCM (Curated mutations)SUPT4H1
CIViC (Clinical Interpretations of Variants in Cancer)SUPT4H1
Cancer3DSUPT4H1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603555   
Orphanet
DisGeNETSUPT4H1
MedgenSUPT4H1
Genetic Testing Registry SUPT4H1
NextProtP63272 [Medical]
GENETestsSUPT4H1
Target ValidationSUPT4H1
Huge Navigator SUPT4H1 [HugePedia]
ClinGenSUPT4H1
Clinical trials, drugs, therapy
MyCancerGenomeSUPT4H1
Protein Interactions : CTDSUPT4H1
Pharm GKB GenePA36253
PharosP63272
Clinical trialSUPT4H1
Miscellaneous
canSAR (ICR)SUPT4H1
HarmonizomeSUPT4H1
DataMed IndexSUPT4H1
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSUPT4H1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:53 CEST 2021

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