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SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

Identity

Alias (NCBI)SPT4
SPT4H
SUPT4H
Supt4a
HGNC (Hugo) SUPT4H1
HGNC Alias symbSPT4H
Spt4
Supt4a
HGNC Previous nameSUPT4H
HGNC Previous namesuppressor of Ty (S.cerevisiae) 4 homolog 1
 suppressor of Ty 4 homolog 1 (S. cerevisiae)
LocusID (NCBI) 6827
Atlas_Id 42452
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58345178 and ends at 58352201 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SUPT4H1 (17q22) / CEP112 (17q24.1)SUPT4H1 (17q22) / PSMD12 (17q24.2)SUPT4H1 (17q22) / SEPT4 (17q22)
SUPT4H1 17q22 / PSMD12 17q24.2SUPT4H1 17q22 / SEPT4 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(17;17)(q22;q24) SUPT4H1/CEP112
t(17;17)(q22;q24) SUPT4H1/PSMD12


External links

Nomenclature
HGNC (Hugo)SUPT4H1   11467
Cards
Entrez_Gene (NCBI)SUPT4H1  6827  SPT4 homolog, DSIF elongation factor subunit
AliasesSPT4; SPT4H; SUPT4H; Supt4a
GeneCards (Weizmann)SUPT4H1
Ensembl hg19 (Hinxton)ENSG00000213246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213246 [Gene_View]  ENSG00000213246 [Sequence]  chr17:58345178-58352201 [Contig_View]  SUPT4H1 [Vega]
ICGC DataPortalENSG00000213246
TCGA cBioPortalSUPT4H1
AceView (NCBI)SUPT4H1
Genatlas (Paris)SUPT4H1
WikiGenes6827
SOURCE (Princeton)SUPT4H1
Genetics Home Reference (NIH)SUPT4H1
Genomic and cartography
GoldenPath hg38 (UCSC)SUPT4H1  -     chr17:58345178-58352201 -  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPT4H1  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathSUPT4H1 - 17q22 [CytoView hg19]  SUPT4H1 - 17q22 [CytoView hg38]
ImmunoBaseENSG00000213246
genome Data Viewer NCBISUPT4H1 [Mapview hg19]  
OMIM603555   
Gene and transcription
Genbank (Entrez)AA311965 AI342302 AI735030 AK129758 AK311986
RefSeq transcript (Entrez)NM_003168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUPT4H1
Alternative Splicing GalleryENSG00000213246
Gene ExpressionSUPT4H1 [ NCBI-GEO ]   SUPT4H1 [ EBI - ARRAY_EXPRESS ]   SUPT4H1 [ SEEK ]   SUPT4H1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT4H1 [ Firebrowse - Broad ]
GenevisibleExpression of SUPT4H1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6827
GTEX Portal (Tissue expression)SUPT4H1
Human Protein AtlasENSG00000213246-SUPT4H1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63272   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63272  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63272
Splice isoforms : SwissVarP63272
PhosPhoSitePlusP63272
Domains : Interpro (EBI)RPABC4/Spt4    Spt4    Spt4/RpoE2_Znf    Spt4_sf   
Domain families : Pfam (Sanger)Spt4 (PF06093)   
Domain families : Pfam (NCBI)pfam06093   
Domain families : Smart (EMBL)Spt4 (SM01389)  
Conserved Domain (NCBI)SUPT4H1
DMDM Disease mutations6827
Blocks (Seattle)SUPT4H1
PDB (RSDB)3H7H    5OIK    6GMH    6GML   
PDB Europe3H7H    5OIK    6GMH    6GML   
PDB (PDBSum)3H7H    5OIK    6GMH    6GML   
PDB (IMB)3H7H    5OIK    6GMH    6GML   
Structural Biology KnowledgeBase3H7H    5OIK    6GMH    6GML   
SCOP (Structural Classification of Proteins)3H7H    5OIK    6GMH    6GML   
CATH (Classification of proteins structures)3H7H    5OIK    6GMH    6GML   
SuperfamilyP63272
Human Protein Atlas [tissue]ENSG00000213246-SUPT4H1 [tissue]
Peptide AtlasP63272
HPRD16026
IPIIPI00002895   
Protein Interaction databases
DIP (DOE-UCLA)P63272
IntAct (EBI)P63272
FunCoupENSG00000213246
BioGRIDSUPT4H1
STRING (EMBL)SUPT4H1
ZODIACSUPT4H1
Ontologies - Pathways
QuickGOP63272
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  DNA-binding transcription factor activity  single-stranded RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin organization  chromatin remodeling  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of viral transcription  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II complex binding  DNA-binding transcription factor activity  single-stranded RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin organization  chromatin remodeling  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of viral transcription  
NDEx NetworkSUPT4H1
Atlas of Cancer Signalling NetworkSUPT4H1
Wikipedia pathwaysSUPT4H1
Orthology - Evolution
OrthoDB6827
GeneTree (enSembl)ENSG00000213246
Phylogenetic Trees/Animal Genes : TreeFamSUPT4H1
HOGENOMP63272
Homologs : HomoloGeneSUPT4H1
Homology/Alignments : Family Browser (UCSC)SUPT4H1
Gene fusions - Rearrangements
Fusion : MitelmanSUPT4H1/CEP112 [17q22/17q24.1]  
Fusion : MitelmanSUPT4H1/PSMD12 [17q22/17q24.2]  
Fusion PortalSUPT4H1 17q22 PSMD12 17q24.2 BRCA
Fusion PortalSUPT4H1 17q22 SEPT4 17q22 BRCA
Fusion : QuiverSUPT4H1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT4H1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT4H1
dbVarSUPT4H1
ClinVarSUPT4H1
1000_GenomesSUPT4H1 
Exome Variant ServerSUPT4H1
GNOMAD BrowserENSG00000213246
Varsome BrowserSUPT4H1
Genetic variants : HAPMAP6827
Genomic Variants (DGV)SUPT4H1 [DGVbeta]
DECIPHERSUPT4H1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPT4H1 
Mutations
ICGC Data PortalSUPT4H1 
TCGA Data PortalSUPT4H1 
Broad Tumor PortalSUPT4H1
OASIS PortalSUPT4H1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT4H1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUPT4H1
Mutations and Diseases : HGMDSUPT4H1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT4H1
DgiDB (Drug Gene Interaction Database)SUPT4H1
DoCM (Curated mutations)SUPT4H1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT4H1 (select a term)
intoGenSUPT4H1
Cancer3DSUPT4H1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603555   
Orphanet
DisGeNETSUPT4H1
MedgenSUPT4H1
Genetic Testing Registry SUPT4H1
NextProtP63272 [Medical]
TSGene6827
GENETestsSUPT4H1
Target ValidationSUPT4H1
Huge Navigator SUPT4H1 [HugePedia]
snp3D : Map Gene to Disease6827
BioCentury BCIQSUPT4H1
ClinGenSUPT4H1
Clinical trials, drugs, therapy
Protein Interactions : CTD6827
Pharm GKB GenePA36253
Clinical trialSUPT4H1
Miscellaneous
canSAR (ICR)SUPT4H1 (select the gene name)
HarmonizomeSUPT4H1
DataMed IndexSUPT4H1
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT4H1
EVEXSUPT4H1
GoPubMedSUPT4H1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 15:38:16 CEST 2020

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