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SUPT4H1 (SPT4 homolog, DSIF elongation factor subunit)

Identity

Alias_namesSUPT4H
suppressor of Ty (S.cerevisiae) 4 homolog 1
suppressor of Ty 4 homolog 1 (S. cerevisiae)
Alias_symbol (synonym)SPT4H
Spt4
Supt4a
Other aliasSPT4
HGNC (Hugo) SUPT4H1
LocusID (NCBI) 6827
Atlas_Id 42452
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58345175 and ends at 58352238 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SUPT4H1 (17q22) / CEP112 (17q24.1)SUPT4H1 (17q22) / PSMD12 (17q24.2)SUPT4H1 (17q22) / SEPT4 (17q22)
SUPT4H1 17q22 / PSMD12 17q24.2SUPT4H1 17q22 / SEPT4 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUPT4H1   11467
Cards
Entrez_Gene (NCBI)SUPT4H1  6827  SPT4 homolog, DSIF elongation factor subunit
AliasesSPT4; SPT4H; SUPT4H; Supt4a
GeneCards (Weizmann)SUPT4H1
Ensembl hg19 (Hinxton)ENSG00000213246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213246 [Gene_View]  chr17:58345175-58352238 [Contig_View]  SUPT4H1 [Vega]
ICGC DataPortalENSG00000213246
TCGA cBioPortalSUPT4H1
AceView (NCBI)SUPT4H1
Genatlas (Paris)SUPT4H1
WikiGenes6827
SOURCE (Princeton)SUPT4H1
Genetics Home Reference (NIH)SUPT4H1
Genomic and cartography
GoldenPath hg38 (UCSC)SUPT4H1  -     chr17:58345175-58352238 -  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPT4H1  -     17q22   [Description]    (hg19-Feb_2009)
EnsemblSUPT4H1 - 17q22 [CytoView hg19]  SUPT4H1 - 17q22 [CytoView hg38]
Mapping of homologs : NCBISUPT4H1 [Mapview hg19]  SUPT4H1 [Mapview hg38]
OMIM603555   
Gene and transcription
Genbank (Entrez)AA311965 AI342302 AI735030 AK129758 AK311986
RefSeq transcript (Entrez)NM_003168
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUPT4H1
Cluster EST : UnigeneHs.718477 [ NCBI ]
CGAP (NCI)Hs.718477
Alternative Splicing GalleryENSG00000213246
Gene ExpressionSUPT4H1 [ NCBI-GEO ]   SUPT4H1 [ EBI - ARRAY_EXPRESS ]   SUPT4H1 [ SEEK ]   SUPT4H1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT4H1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6827
GTEX Portal (Tissue expression)SUPT4H1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63272   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63272  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63272
Splice isoforms : SwissVarP63272
PhosPhoSitePlusP63272
Domains : Interpro (EBI)RPABC4/Spt4    Spt4    Spt4-like    Spt4/RpoE2_Znf   
Domain families : Pfam (Sanger)Spt4 (PF06093)   
Domain families : Pfam (NCBI)pfam06093   
Domain families : Smart (EMBL)Spt4 (SM01389)  
Conserved Domain (NCBI)SUPT4H1
DMDM Disease mutations6827
Blocks (Seattle)SUPT4H1
PDB (SRS)3H7H   
PDB (PDBSum)3H7H   
PDB (IMB)3H7H   
PDB (RSDB)3H7H   
Structural Biology KnowledgeBase3H7H   
SCOP (Structural Classification of Proteins)3H7H   
CATH (Classification of proteins structures)3H7H   
SuperfamilyP63272
Human Protein AtlasENSG00000213246
Peptide AtlasP63272
HPRD16026
IPIIPI00002895   
Protein Interaction databases
DIP (DOE-UCLA)P63272
IntAct (EBI)P63272
FunCoupENSG00000213246
BioGRIDSUPT4H1
STRING (EMBL)SUPT4H1
ZODIACSUPT4H1
Ontologies - Pathways
QuickGOP63272
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core binding  transcription factor activity, sequence-specific DNA binding  single-stranded RNA binding  protein binding  nucleus  nucleoplasm  chromatin remodeling  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of viral transcription  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core binding  transcription factor activity, sequence-specific DNA binding  single-stranded RNA binding  protein binding  nucleus  nucleoplasm  chromatin remodeling  regulation of transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  zinc ion binding  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  regulation of transcription elongation from RNA polymerase II promoter  negative regulation of transcription elongation from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of viral transcription  
NDEx NetworkSUPT4H1
Atlas of Cancer Signalling NetworkSUPT4H1
Wikipedia pathwaysSUPT4H1
Orthology - Evolution
OrthoDB6827
GeneTree (enSembl)ENSG00000213246
Phylogenetic Trees/Animal Genes : TreeFamSUPT4H1
HOVERGENP63272
HOGENOMP63272
Homologs : HomoloGeneSUPT4H1
Homology/Alignments : Family Browser (UCSC)SUPT4H1
Gene fusions - Rearrangements
Fusion : MitelmanSUPT4H1/CEP112 [17q22/17q24.1]  
Fusion : MitelmanSUPT4H1/PSMD12 [17q22/17q24.2]  [t(17;17)(q22;q24)]  
Fusion: TCGASUPT4H1 17q22 PSMD12 17q24.2 BRCA
Fusion: TCGASUPT4H1 17q22 SEPT4 17q22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT4H1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT4H1
dbVarSUPT4H1
ClinVarSUPT4H1
1000_GenomesSUPT4H1 
Exome Variant ServerSUPT4H1
ExAC (Exome Aggregation Consortium)SUPT4H1 (select the gene name)
Genetic variants : HAPMAP6827
Genomic Variants (DGV)SUPT4H1 [DGVbeta]
DECIPHERSUPT4H1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPT4H1 
Mutations
ICGC Data PortalSUPT4H1 
TCGA Data PortalSUPT4H1 
Broad Tumor PortalSUPT4H1
OASIS PortalSUPT4H1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT4H1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUPT4H1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT4H1
DgiDB (Drug Gene Interaction Database)SUPT4H1
DoCM (Curated mutations)SUPT4H1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT4H1 (select a term)
intoGenSUPT4H1
Cancer3DSUPT4H1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603555   
Orphanet
MedgenSUPT4H1
Genetic Testing Registry SUPT4H1
NextProtP63272 [Medical]
TSGene6827
GENETestsSUPT4H1
Target ValidationSUPT4H1
Huge Navigator SUPT4H1 [HugePedia]
snp3D : Map Gene to Disease6827
BioCentury BCIQSUPT4H1
ClinGenSUPT4H1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6827
Chemical/Pharm GKB GenePA36253
Clinical trialSUPT4H1
<.TH>žTH$ ALIGN=LEFT COLSPAN=1 BGCOLOR=#DDDDFC>Miscellaneous
canSAR (ICR)SUPT4H1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT4H1
EVEXSUPT4H1
GoPubMedSUPT4H1
iHOPSUPT4H1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:33:47 CEST 2017

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