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SUPT5H (SPT5 homolog, DSIF elongation factor subunit)

Identity

Alias_namessuppressor of Ty (S.cerevisiae) 5 homolog
suppressor of Ty 5 homolog (S. cerevisiae)
Alias_symbol (synonym)SPT5H
SPT5
FLJ34157
Other aliasTat-CT1
HGNC (Hugo) SUPT5H
LocusID (NCBI) 6829
Atlas_Id 42453
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39936186 and ends at 39967308 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NOL9 (1p36.31) / SUPT5H (19q13.2)RPS4X (Xq13.1) / SUPT5H (19q13.2)SUPT5H (19q13.2) / CTSB (8p23.1)
SUPT5H (19q13.2) / NADSYN1 (11q13.4)SUPT5H (19q13.2) / SIPA1L3 (19q13.13)SUPT5H (19q13.2) / SUPT5H (19q13.2)
SUPT5H 19q13.2 / NADSYN1 11q13.4SUPT5H 19q13.2 / SIPA1L3 19q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUPT5H   11469
Cards
Entrez_Gene (NCBI)SUPT5H  6829  SPT5 homolog, DSIF elongation factor subunit
AliasesSPT5; SPT5H; Tat-CT1
GeneCards (Weizmann)SUPT5H
Ensembl hg19 (Hinxton)ENSG00000196235 [Gene_View]  chr19:39936186-39967308 [Contig_View]  SUPT5H [Vega]
Ensembl hg38 (Hinxton)ENSG00000196235 [Gene_View]  chr19:39936186-39967308 [Contig_View]  SUPT5H [Vega]
ICGC DataPortalENSG00000196235
TCGA cBioPortalSUPT5H
AceView (NCBI)SUPT5H
Genatlas (Paris)SUPT5H
WikiGenes6829
SOURCE (Princeton)SUPT5H
Genetics Home Reference (NIH)SUPT5H
Genomic and cartography
GoldenPath hg19 (UCSC)SUPT5H  -     chr19:39936186-39967308 +  19q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SUPT5H  -     19q13.2   [Description]    (hg38-Dec_2013)
EnsemblSUPT5H - 19q13.2 [CytoView hg19]  SUPT5H - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBISUPT5H [Mapview hg19]  SUPT5H [Mapview hg38]
OMIM602102   
Gene and transcription
Genbank (Entrez)AB000516 AB209257 AF040253 AF052165 AK091476
RefSeq transcript (Entrez)NM_001111020 NM_001130824 NM_001130825 NM_001319990 NM_001319991 NM_003169
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)SUPT5H
Cluster EST : UnigeneHs.631604 [ NCBI ]
CGAP (NCI)Hs.631604
Alternative Splicing GalleryENSG00000196235
Gene ExpressionSUPT5H [ NCBI-GEO ]   SUPT5H [ EBI - ARRAY_EXPRESS ]   SUPT5H [ SEEK ]   SUPT5H [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT5H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6829
GTEX Portal (Tissue expression)SUPT5H
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00267   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00267  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00267
Splice isoforms : SwissVarO00267
PhosPhoSitePlusO00267
Domains : Interpro (EBI)KOW    NGN_dom    Spt5_C_dom    Spt5_N    TF_Spt5    TF_Spt5_NGN-domain    Translation_prot_SH3-like   
Domain families : Pfam (Sanger)KOW (PF00467)    Spt5-NGN (PF03439)    Spt5_N (PF11942)   
Domain families : Pfam (NCBI)pfam00467    pfam03439    pfam11942   
Domain families : Smart (EMBL)CTD (SM01104)  KOW (SM00739)  NGN (SM00738)  
Conserved Domain (NCBI)SUPT5H
DMDM Disease mutations6829
Blocks (Seattle)SUPT5H
PDB (SRS)2DO3    2E6Z    2E70    3H7H    4L1U   
PDB (PDBSum)2DO3    2E6Z    2E70    3H7H    4L1U   
PDB (IMB)2DO3    2E6Z    2E70    3H7H    4L1U   
PDB (RSDB)2DO3    2E6Z    2E70    3H7H    4L1U   
Structural Biology KnowledgeBase2DO3    2E6Z    2E70    3H7H    4L1U   
SCOP (Structural Classification of Proteins)2DO3    2E6Z    2E70    3H7H    4L1U   
CATH (Classification of proteins structures)2DO3    2E6Z    2E70    3H7H    4L1U   
SuperfamilyO00267
Human Protein AtlasENSG00000196235
Peptide AtlasO00267
HPRD03655
IPIIPI00298058   IPI00655641   IPI00911042   IPI01010195   
Protein Interaction databases
DIP (DOE-UCLA)O00267
IntAct (EBI)O00267
FunCoupENSG00000196235
BioGRIDSUPT5H
STRING (EMBL)SUPT5H
ZODIACSUPT5H
Ontologies - Pathways
QuickGOO00267
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin remodeling  DNA-templated transcription, elongation  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  cell cycle  response to organic substance  positive regulation of macroautophagy  enzyme binding  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  single stranded viral RNA replication via double stranded DNA intermediate  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of viral transcription  negative regulation of mRNA polyadenylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin remodeling  DNA-templated transcription, elongation  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  cell cycle  response to organic substance  positive regulation of macroautophagy  enzyme binding  DSIF complex  negative regulation of DNA-templated transcription, elongation  positive regulation of DNA-templated transcription, elongation  single stranded viral RNA replication via double stranded DNA intermediate  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of viral transcription  negative regulation of mRNA polyadenylation  
NDEx NetworkSUPT5H
Atlas of Cancer Signalling NetworkSUPT5H
Wikipedia pathwaysSUPT5H
Orthology - Evolution
OrthoDB6829
GeneTree (enSembl)ENSG00000196235
Phylogenetic Trees/Animal Genes : TreeFamSUPT5H
HOVERGENO00267
HOGENOMO00267
Homologs : HomoloGeneSUPT5H
Homology/Alignments : Family Browser (UCSC)SUPT5H
Gene fusions - Rearrangements
Fusion : MitelmanSUPT5H/NADSYN1 [19q13.2/11q13.4]  
Fusion : MitelmanSUPT5H/SIPA1L3 [19q13.2/19q13.13]  [t(19;19)(q13;q13)]  
Fusion: TCGASUPT5H 19q13.2 NADSYN1 11q13.4 LUAD
Fusion: TCGASUPT5H 19q13.2 SIPA1L3 19q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT5H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT5H
dbVarSUPT5H
ClinVarSUPT5H
1000_GenomesSUPT5H 
Exome Variant ServerSUPT5H
ExAC (Exome Aggregation Consortium)SUPT5H (select the gene name)
Genetic variants : HAPMAP6829
Genomic Variants (DGV)SUPT5H [DGVbeta]
DECIPHER (Syndromes)19:39936186-39967308  ENSG00000196235
CONAN: Copy Number AnalysisSUPT5H 
Mutations
ICGC Data PortalSUPT5H 
TCGA Data PortalSUPT5H 
Broad Tumor PortalSUPT5H
OASIS PortalSUPT5H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT5H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUPT5H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT5H
DgiDB (Drug Gene Interaction Database)SUPT5H
DoCM (Curated mutations)SUPT5H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT5H (select a term)
intoGenSUPT5H
Cancer3DSUPT5H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602102   
Orphanet
MedgenSUPT5H
Genetic Testing Registry SUPT5H
NextProtO00267 [Medical]
TSGene6829
GENETestsSUPT5H
Huge Navigator SUPT5H [HugePedia]
snp3D : Map Gene to Disease6829
BioCentury BCIQSUPT5H
ClinGenSUPT5H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6829
Chemical/Pharm GKB GenePA36255
Clinical trialSUPT5H
Miscellaneous
canSAR (ICR)SUPT5H (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT5H
EVEXSUPT5H
GoPubMedSUPT5H
iHOPSUPT5H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:21:29 CEST 2017

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