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SUPT6H (SPT6 homolog, histone chaperone)

Identity

Alias_namessuppressor of Ty (S.cerevisiae) 6 homolog
suppressor of Ty 6 homolog (S. cerevisiae)
Alias_symbol (synonym)KIAA0162
SPT6H
Other aliasSPT6
emb-5
HGNC (Hugo) SUPT6H
LocusID (NCBI) 6830
Atlas_Id 42454
Location 17q11.2  [Link to chromosome band 17q11]
Location_base_pair Starts at 28662198 and ends at 28702684 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASNSD1 (2q32.2) / SUPT6H (17q11.2)NF1 (17q11.2) / SUPT6H (17q11.2)R3HDM2 (12q13.3) / SUPT6H (17q11.2)
SUPT6H (17q11.2) / APOB (2p24.1)SUPT6H (17q11.2) / BGN (Xq28)SUPT6H (17q11.2) / DTYMK (2q37.3)
SUPT6H (17q11.2) / MRO (18q21.2)SUPT6H (17q11.2) / SUPT6H (17q11.2)SUPT6H (17q11.2) / UTP6 (17q11.2)
R3HDM2 12q13.3 / SUPT6H 17q11.2SUPT6H 17q11.2 / MRO 18q21.2SUPT6H 17q11.2 / UTP6 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUPT6H   11470
Cards
Entrez_Gene (NCBI)SUPT6H  6830  SPT6 homolog, histone chaperone
AliasesSPT6; SPT6H; emb-5
GeneCards (Weizmann)SUPT6H
Ensembl hg19 (Hinxton)ENSG00000109111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000109111 [Gene_View]  chr17:28662198-28702684 [Contig_View]  SUPT6H [Vega]
ICGC DataPortalENSG00000109111
TCGA cBioPortalSUPT6H
AceView (NCBI)SUPT6H
Genatlas (Paris)SUPT6H
WikiGenes6830
SOURCE (Princeton)SUPT6H
Genetics Home Reference (NIH)SUPT6H
Genomic and cartography
GoldenPath hg38 (UCSC)SUPT6H  -     chr17:28662198-28702684 +  17q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPT6H  -     17q11.2   [Description]    (hg19-Feb_2009)
EnsemblSUPT6H - 17q11.2 [CytoView hg19]  SUPT6H - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBISUPT6H [Mapview hg19]  SUPT6H [Mapview hg38]
OMIM601333   
Gene and transcription
Genbank (Entrez)AF070532 AK126585 AL833607 AW135492 BC003692
RefSeq transcript (Entrez)NM_001320755 NM_003170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUPT6H
Cluster EST : UnigeneHs.735114 [ NCBI ]
CGAP (NCI)Hs.735114
Alternative Splicing GalleryENSG00000109111
Gene ExpressionSUPT6H [ NCBI-GEO ]   SUPT6H [ EBI - ARRAY_EXPRESS ]   SUPT6H [ SEEK ]   SUPT6H [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT6H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6830
GTEX Portal (Tissue expression)SUPT6H
Human Protein AtlasENSG00000109111-SUPT6H [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7KZ85   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7KZ85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7KZ85
Splice isoforms : SwissVarQ7KZ85
PhosPhoSitePlusQ7KZ85
Domaine pattern : Prosite (Expaxy)S1 (PS50126)    SH2 (PS50001)   
Domains : Interpro (EBI)NA-bd_OB-fold    RNaseH-like_dom    RuvA_2-like    S1_dom    S1_domain    SH2    Spt6_acidic_N_dom    Spt6_dom    Spt6_HHH    Spt6_HTH_DNA-bd_dom    Spt6_YqgF    Tex-like_dom    Tex_RuvX-like_dom    TF_Spt6    YqgF/RNaseH-like_dom   
Domain families : Pfam (Sanger)DLD (PF14878)    HHH_7 (PF14635)    HTH_44 (PF14641)    S1 (PF00575)    SH2_2 (PF14633)    SPT6_acidic (PF14632)    YqgF (PF14639)   
Domain families : Pfam (NCBI)pfam14878    pfam14635    pfam14641    pfam00575    pfam14633    pfam14632    pfam14639   
Domain families : Smart (EMBL)S1 (SM00316)  SH2 (SM00252)  YqgFc (SM00732)  
Conserved Domain (NCBI)SUPT6H
DMDM Disease mutations6830
Blocks (Seattle)SUPT6H
SuperfamilyQ7KZ85
Human Protein Atlas [tissue]ENSG00000109111-SUPT6H [tissue]
Peptide AtlasQ7KZ85
HPRD03211
IPIIPI00784161   IPI00430770   IPI00456683   
Protein Interaction databases
DIP (DOE-UCLA)Q7KZ85
IntAct (EBI)Q7KZ85
FunCoupENSG00000109111
BioGRIDSUPT6H
STRING (EMBL)SUPT6H
ZODIACSUPT6H
Ontologies - Pathways
QuickGOQ7KZ85
Ontology : AmiGOtranscription factor activity, core RNA polymerase II binding  DNA binding  transcription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  chromatin remodeling  chromatin silencing  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  transcription elongation factor complex  RNA splicing  regulation of mRNA export from nucleus  viral process  nucleosome binding  positive regulation of transcription elongation from RNA polymerase II promoter  nucleosome organization  transcriptionally active chromatin  histone binding  mRNA transcription from RNA polymerase II promoter  regulation of isotype switching  regulation of mRNA processing  regulation of mRNA processing  mRNA transport  regulation of muscle cell differentiation  negative regulation of histone H3-K27 methylation  chromatin maintenance  
Ontology : EGO-EBItranscription factor activity, core RNA polymerase II binding  DNA binding  transcription factor activity, sequence-specific DNA binding  RNA binding  protein binding  nucleus  nucleoplasm  chromatin remodeling  chromatin silencing  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  mRNA processing  transcription elongation factor complex  RNA splicing  regulation of mRNA export from nucleus  viral process  nucleosome binding  positive regulation of transcription elongation from RNA polymerase II promoter  nucleosome organization  transcriptionally active chromatin  histone binding  mRNA transcription from RNA polymerase II promoter  regulation of isotype switching  regulation of mRNA processing  regulation of mRNA processing  mRNA transport  regulation of muscle cell differentiation  negative regulation of histone H3-K27 methylation  chromatin maintenance  
NDEx NetworkSUPT6H
Atlas of Cancer Signalling NetworkSUPT6H
Wikipedia pathwaysSUPT6H
Orthology - Evolution
OrthoDB6830
GeneTree (enSembl)ENSG00000109111
Phylogenetic Trees/Animal Genes : TreeFamSUPT6H
HOVERGENQ7KZ85
HOGENOMQ7KZ85
Homologs : HomoloGeneSUPT6H
Homology/Alignments : Family Browser (UCSC)SUPT6H
Gene fusions - Rearrangements
Fusion : MitelmanR3HDM2/SUPT6H [12q13.3/17q11.2]  [t(12;17)(q13;q11)]  
Fusion : MitelmanSUPT6H/MRO [17q11.2/18q21.2]  [t(17;18)(q11;q21)]  
Fusion : MitelmanSUPT6H/UTP6 [17q11.2/17q11.2]  [t(17;17)(q11;q11)]  
Fusion: TCGA_MDACCR3HDM2 12q13.3 SUPT6H 17q11.2 BRCA
Fusion: TCGA_MDACCSUPT6H 17q11.2 MRO 18q21.2 HNSC
Fusion: TCGA_MDACCSUPT6H 17q11.2 UTP6 17q11.2 BRCA
Tumor Fusion PortalSUPT6H
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPT6H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT6H
dbVarSUPT6H
ClinVarSUPT6H
1000_GenomesSUPT6H 
Exome Variant ServerSUPT6H
ExAC (Exome Aggregation Consortium)ENSG00000109111
GNOMAD BrowserENSG00000109111
Genetic variants : HAPMAP6830
Genomic Variants (DGV)SUPT6H [DGVbeta]
DECIPHERSUPT6H [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPT6H 
Mutations
ICGC Data PortalSUPT6H 
TCGA Data PortalSUPT6H 
Broad Tumor PortalSUPT6H
OASIS PortalSUPT6H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT6H  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUPT6H
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT6H
DgiDB (Drug Gene Interaction Database)SUPT6H
DoCM (Curated mutations)SUPT6H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT6H (select a term)
intoGenSUPT6H
Cancer3DSUPT6H(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601333   
Orphanet
DisGeNETSUPT6H
MedgenSUPT6H
Genetic Testing Registry SUPT6H
NextProtQ7KZ85 [Medical]
TSGene6830
GENETestsSUPT6H
Target ValidationSUPT6H
Huge Navigator SUPT6H [HugePedia]
snp3D : Map Gene to Disease6830
BioCentury BCIQSUPT6H
ClinGenSUPT6H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6830
Chemical/Pharm GKB GenePA36256
Clinical trialSUPT6H
Miscellaneous
canSAR (ICR)SUPT6H (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT6H
EVEXSUPT6H
GoPubMedSUPT6H
iHOPSUPT6H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:37:16 CET 2017

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