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SUPT6H (SPT6 homolog, histone chaperone)

Identity

Other namesSPT6
SPT6H
emb-5
HGNC (Hugo) SUPT6H
LocusID (NCBI) 6830
Atlas_Id 42454
Location 17q11.2
Location_base_pair Starts at 26989302 and ends at 27029249 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ASNSD1 (2q32.2) / SUPT6H (17q11.2)NF1 (17q11.2) / SUPT6H (17q11.2)R3HDM2 (12q13.3) / SUPT6H (17q11.2)
SUPT6H (17q11.2) / APOB (2p24.1)SUPT6H (17q11.2) / BGN (Xq28)SUPT6H (17q11.2) / DTYMK (2q37.3)
SUPT6H (17q11.2) / MRO (18q21.2)SUPT6H (17q11.2) / SUPT6H (17q11.2)SUPT6H (17q11.2) / UTP6 (17q11.2)
R3HDM2 12q13.3 / SUPT6H 17q11.2SUPT6H 17q11.2 / MRO 18q21.2SUPT6H 17q11.2 / UTP6 17q11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUPT6H   11470
Cards
Entrez_Gene (NCBI)SUPT6H  6830  SPT6 homolog, histone chaperone
AliasesSPT6; SPT6H; emb-5
GeneCards (Weizmann)SUPT6H
Ensembl hg19 (Hinxton)ENSG00000109111 [Gene_View]  chr17:26989302-27029249 [Contig_View]  SUPT6H [Vega]
Ensembl hg38 (Hinxton)ENSG00000109111 [Gene_View]  chr17:26989302-27029249 [Contig_View]  SUPT6H [Vega]
ICGC DataPortalENSG00000109111
TCGA cBioPortalSUPT6H
AceView (NCBI)SUPT6H
Genatlas (Paris)SUPT6H
WikiGenes6830
SOURCE (Princeton)SUPT6H
Genomic and cartography
GoldenPath hg19 (UCSC)SUPT6H  -     chr17:26989302-27029249 +  17q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SUPT6H  -     17q11.2   [Description]    (hg38-Dec_2013)
EnsemblSUPT6H - 17q11.2 [CytoView hg19]  SUPT6H - 17q11.2 [CytoView hg38]
Mapping of homologs : NCBISUPT6H [Mapview hg19]  SUPT6H [Mapview hg38]
OMIM601333   
Gene and transcription
Genbank (Entrez)AF070532 AK126585 AL833607 AW135492 BC003692
RefSeq transcript (Entrez)NM_001320755 NM_003170
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)SUPT6H
Cluster EST : UnigeneHs.735114 [ NCBI ]
CGAP (NCI)Hs.735114
Alternative Splicing GalleryENSG00000109111
Gene ExpressionSUPT6H [ NCBI-GEO ]   SUPT6H [ EBI - ARRAY_EXPRESS ]   SUPT6H [ SEEK ]   SUPT6H [ MEM ]
Gene Expression Viewer (FireBrowse)SUPT6H [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6830
GTEX Portal (Tissue expression)SUPT6H
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7KZ85 (Uniprot)
NextProtQ7KZ85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7KZ85
Splice isoforms : SwissVarQ7KZ85 (Swissvar)
PhosPhoSitePlusQ7KZ85
Domaine pattern : Prosite (Expaxy)S1 (PS50126)    SH2 (PS50001)   
Domains : Interpro (EBI)NA-bd_OB-fold    RNaseH-like_dom    RuvA_2-like    S1_dom    S1_domain    SH2    Spt6_acidic_N_dom    Spt6_dom    Spt6_HHH    Spt6_HTH_DNA-bd_dom    Spt6_YqgF    Tex-like_dom    Tex_RuvX-like_dom    TF_Spt6    YqgF/RNaseH-like_dom   
Domain families : Pfam (Sanger)DLD (PF14878)    HHH_7 (PF14635)    HTH_44 (PF14641)    S1 (PF00575)    SH2_2 (PF14633)    SPT6_acidic (PF14632)    YqgF (PF14639)   
Domain families : Pfam (NCBI)pfam14878    pfam14635    pfam14641    pfam00575    pfam14633    pfam14632    pfam14639   
Domain families : Smart (EMBL)S1 (SM00316)  SH2 (SM00252)  YqgFc (SM00732)  
DMDM Disease mutations6830
Blocks (Seattle)SUPT6H
SuperfamilyQ7KZ85
Human Protein AtlasENSG00000109111
Peptide AtlasQ7KZ85
HPRD03211
IPIIPI00784161   IPI00430770   IPI00456683   
Protein Interaction databases
DIP (DOE-UCLA)Q7KZ85
IntAct (EBI)Q7KZ85
FunCoupENSG00000109111
BioGRIDSUPT6H
STRING (EMBL)SUPT6H
ZODIACSUPT6H
Ontologies - Pathways
QuickGOQ7KZ85
Ontology : AmiGODNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  RNA splicing  regulation of mRNA export from nucleus  viral process  positive regulation of transcription elongation from RNA polymerase II promoter  histone binding  poly(A) RNA binding  regulation of isotype switching  regulation of mRNA processing  mRNA transport  regulation of muscle cell differentiation  negative regulation of histone H3-K27 methylation  
Ontology : EGO-EBIDNA binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  chromatin remodeling  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  RNA splicing  regulation of mRNA export from nucleus  viral process  positive regulation of transcription elongation from RNA polymerase II promoter  histone binding  poly(A) RNA binding  regulation of isotype switching  regulation of mRNA processing  mRNA transport  regulation of muscle cell differentiation  negative regulation of histone H3-K27 methylation  
NDEx Network
Atlas of Cancer Signalling NetworkSUPT6H
Wikipedia pathwaysSUPT6H
Orthology - Evolution
OrthoDB6830
GeneTree (enSembl)ENSG00000109111
Phylogenetic Trees/Animal Genes : TreeFamSUPT6H
Homologs : HomoloGeneSUPT6H
Homology/Alignments : Family Browser (UCSC)SUPT6H
Gene fusions - Rearrangements
Fusion: TCGAR3HDM2 12q13.3 SUPT6H 17q11.2 BRCA
Fusion: TCGASUPT6H 17q11.2 MRO 18q21.2 HNSC
Fusion: TCGASUPT6H 17q11.2 UTP6 17q11.2 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerSUPT6H [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPT6H
dbVarSUPT6H
ClinVarSUPT6H
1000_GenomesSUPT6H 
Exome Variant ServerSUPT6H
ExAC (Exome Aggregation Consortium)SUPT6H (select the gene name)
Genetic variants : HAPMAP6830
Genomic Variants (DGV)SUPT6H [DGVbeta]
Mutations
ICGC Data PortalSUPT6H 
TCGA Data PortalSUPT6H 
Broad Tumor PortalSUPT6H
OASIS PortalSUPT6H [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPT6H 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUPT6H
DgiDB (Drug Gene Interaction Database)SUPT6H
DoCM (Curated mutations)SUPT6H (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPT6H (select a term)
intoGenSUPT6H
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:26989302-27029249  ENSG00000109111
CONAN: Copy Number AnalysisSUPT6H 
Mutations and Diseases : HGMDSUPT6H
OMIM601333   
MedgenSUPT6H
Genetic Testing Registry SUPT6H
NextProtQ7KZ85 [Medical]
TSGene6830
GENETestsSUPT6H
Huge Navigator SUPT6H [HugePedia]
snp3D : Map Gene to Disease6830
BioCentury BCIQSUPT6H
ClinGenSUPT6H
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6830
Chemical/Pharm GKB GenePA36256
Clinical trialSUPT6H
Miscellaneous
canSAR (ICR)SUPT6H (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPT6H
EVEXSUPT6H
GoPubMedSUPT6H
iHOPSUPT6H
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:23:28 CEST 2016

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