SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)

2003-11-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
SPT6,SPT6H,emb-5
FUSION GENES

Other Information

Locus ID:

NCBI: 6830
MIM: 601333
HGNC: 11470
Ensembl: ENSG00000109111

Variants:

dbSNP: 6830
ClinVar: 6830
TCGA: ENSG00000109111
COSMIC: SUPT6H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109111ENST00000314616Q7KZ85
ENSG00000109111ENST00000347486Q7KZ85
ENSG00000109111ENST00000577713J3QS64
ENSG00000109111ENST00000584312K7EK85

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150601542004Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro.52
301355782018Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.52
228436872012The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.28
215188742011Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.21
255907592015The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells.20
244410442015SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.18
304497232018Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.13
223161382012Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.8
221712522012The cellular protein SPT6 is required for efficient replication of human cytomegalovirus.2

Citation

Dessen P

SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42454/supt6h