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SUPV3L1 (Suv3 like RNA helicase)

Identity

Alias (NCBI)SUV3
HGNC (Hugo) SUPV3L1
HGNC Alias symbSUV3
HGNC Previous namesuppressor of var1 (S.cerevisiae) 3-like 1
 suppressor of var1, 3-like 1 (S. cerevisiae)
LocusID (NCBI) 6832
Atlas_Id 47109
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69180234 and ends at 69209093 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTB (7p22.1) / SUPV3L1 (10q22.1)SUPV3L1 (10q22.1) / PRKG1 (10q11.23)SUPV3L1 (10q22.1) / VPS26A (10q22.1)
UBR1 (15q15.2) / SUPV3L1 (10q22.1)SUPV3L1 10q22.1 / VPS26A 10q22.1UBR1 15q15.2 / SUPV3L1 10q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)SUPV3L1   11471
Cards
Entrez_Gene (NCBI)SUPV3L1    Suv3 like RNA helicase
AliasesSUV3
GeneCards (Weizmann)SUPV3L1
Ensembl hg19 (Hinxton)ENSG00000156502 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156502 [Gene_View]  ENSG00000156502 [Sequence]  chr10:69180234-69209093 [Contig_View]  SUPV3L1 [Vega]
ICGC DataPortalENSG00000156502
TCGA cBioPortalSUPV3L1
AceView (NCBI)SUPV3L1
Genatlas (Paris)SUPV3L1
SOURCE (Princeton)SUPV3L1
Genetics Home Reference (NIH)SUPV3L1
Genomic and cartography
GoldenPath hg38 (UCSC)SUPV3L1  -     chr10:69180234-69209093 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPV3L1  -     10q22.1   [Description]    (hg19-Feb_2009)
GoldenPathSUPV3L1 - 10q22.1 [CytoView hg19]  SUPV3L1 - 10q22.1 [CytoView hg38]
ImmunoBaseENSG00000156502
Genome Data Viewer NCBISUPV3L1 [Mapview hg19]  
OMIM605122   
Gene and transcription
Genbank (Entrez)AF042169 AK290416 AK299670 BC036112 BM675613
RefSeq transcript (Entrez)NM_001301683 NM_001323584 NM_001323585 NM_001323586 NM_001323587 NM_001323588 NM_003171
Consensus coding sequences : CCDS (NCBI)SUPV3L1
Gene ExpressionSUPV3L1 [ NCBI-GEO ]   SUPV3L1 [ EBI - ARRAY_EXPRESS ]   SUPV3L1 [ SEEK ]   SUPV3L1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUPV3L1 [ Firebrowse - Broad ]
GenevisibleExpression of SUPV3L1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6832
GTEX Portal (Tissue expression)SUPV3L1
Human Protein AtlasENSG00000156502-SUPV3L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYB8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYB8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYB8
PhosPhoSitePlusQ8IYB8
Domaine pattern : Prosite (Expaxy)HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)Helicase_C    P-loop_NTPase    SUV3_C    Suv3_C_1    Suv3_N   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    SUV3_C (PF12513)    Suv3_C_1 (PF18147)    Suv3_N (PF18114)   
Domain families : Pfam (NCBI)pfam00271    pfam12513    pfam18147    pfam18114   
Domain families : Smart (EMBL)HELICc (SM00490)  
Conserved Domain (NCBI)SUPV3L1
PDB (RSDB)3RC3    3RC8   
PDB Europe3RC3    3RC8   
PDB (PDBSum)3RC3    3RC8   
PDB (IMB)3RC3    3RC8   
Structural Biology KnowledgeBase3RC3    3RC8   
SCOP (Structural Classification of Proteins)3RC3    3RC8   
CATH (Classification of proteins structures)3RC3    3RC8   
SuperfamilyQ8IYB8
AlphaFold pdb e-kbQ8IYB8   
Human Protein Atlas [tissue]ENSG00000156502-SUPV3L1 [tissue]
HPRD05493
Protein Interaction databases
DIP (DOE-UCLA)Q8IYB8
IntAct (EBI)Q8IYB8
BioGRIDSUPV3L1
STRING (EMBL)SUPV3L1
ZODIACSUPV3L1
Ontologies - Pathways
QuickGOQ8IYB8
Ontology : AmiGOmitochondrial mRNA catabolic process  positive regulation of mitochondrial RNA catabolic process  positive regulation of mitochondrial RNA catabolic process  mitochondrial RNA 3'-end processing  mitochondrial RNA 3'-end processing  DNA binding  DNA helicase activity  RNA binding  RNA helicase activity  RNA helicase activity  double-stranded RNA binding  helicase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial matrix  DNA recombination  RNA catabolic process  RNA catabolic process  hydrolase activity, acting on acid anhydrides  positive regulation of cell growth  DNA duplex unwinding  3'-5' RNA helicase activity  mitochondrial ncRNA surveillance  mitochondrial mRNA surveillance  mitochondrial nucleoid  protein homodimerization activity  negative regulation of apoptotic process  mitochondrial degradosome  mitochondrial degradosome  mitochondrion morphogenesis  chromatin maintenance  mitochondrial RNA surveillance  
Ontology : EGO-EBImitochondrial mRNA catabolic process  positive regulation of mitochondrial RNA catabolic process  positive regulation of mitochondrial RNA catabolic process  mitochondrial RNA 3'-end processing  mitochondrial RNA 3'-end processing  DNA binding  DNA helicase activity  RNA binding  RNA helicase activity  RNA helicase activity  double-stranded RNA binding  helicase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial matrix  DNA recombination  RNA catabolic process  RNA catabolic process  hydrolase activity, acting on acid anhydrides  positive regulation of cell growth  DNA duplex unwinding  3'-5' RNA helicase activity  mitochondrial ncRNA surveillance  mitochondrial mRNA surveillance  mitochondrial nucleoid  protein homodimerization activity  negative regulation of apoptotic process  mitochondrial degradosome  mitochondrial degradosome  mitochondrion morphogenesis  chromatin maintenance  mitochondrial RNA surveillance  
NDEx NetworkSUPV3L1
Atlas of Cancer Signalling NetworkSUPV3L1
Wikipedia pathwaysSUPV3L1
Orthology - Evolution
OrthoDB6832
GeneTree (enSembl)ENSG00000156502
Phylogenetic Trees/Animal Genes : TreeFamSUPV3L1
Homologs : HomoloGeneSUPV3L1
Homology/Alignments : Family Browser (UCSC)SUPV3L1
Gene fusions - Rearrangements
Fusion : MitelmanSUPV3L1/VPS26A [10q22.1/10q22.1]  
Fusion : MitelmanUBR1/SUPV3L1 [15q15.2/10q22.1]  
Fusion : QuiverSUPV3L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPV3L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPV3L1
dbVarSUPV3L1
ClinVarSUPV3L1
MonarchSUPV3L1
1000_GenomesSUPV3L1 
Exome Variant ServerSUPV3L1
GNOMAD BrowserENSG00000156502
Varsome BrowserSUPV3L1
ACMGSUPV3L1 variants
VarityQ8IYB8
Genomic Variants (DGV)SUPV3L1 [DGVbeta]
DECIPHERSUPV3L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPV3L1 
Mutations
ICGC Data PortalSUPV3L1 
TCGA Data PortalSUPV3L1 
Broad Tumor PortalSUPV3L1
OASIS PortalSUPV3L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPV3L1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUPV3L1
Mutations and Diseases : HGMDSUPV3L1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSUPV3L1
DgiDB (Drug Gene Interaction Database)SUPV3L1
DoCM (Curated mutations)SUPV3L1
CIViC (Clinical Interpretations of Variants in Cancer)SUPV3L1
Cancer3DSUPV3L1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605122   
Orphanet
DisGeNETSUPV3L1
MedgenSUPV3L1
Genetic Testing Registry SUPV3L1
NextProtQ8IYB8 [Medical]
GENETestsSUPV3L1
Target ValidationSUPV3L1
Huge Navigator SUPV3L1 [HugePedia]
ClinGenSUPV3L1
Clinical trials, drugs, therapy
MyCancerGenomeSUPV3L1
Protein Interactions : CTDSUPV3L1
Pharm GKB GenePA36257
PharosQ8IYB8
Clinical trialSUPV3L1
Miscellaneous
canSAR (ICR)SUPV3L1
HarmonizomeSUPV3L1
DataMed IndexSUPV3L1
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSUPV3L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:33:54 CEST 2021
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