Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SUPV3L1 (Suv3 like RNA helicase)

Identity

Alias_namessuppressor of var1 (S.cerevisiae) 3-like 1
suppressor of var1, 3-like 1 (S. cerevisiae)
Alias_symbol (synonym)SUV3
Other alias
HGNC (Hugo) SUPV3L1
LocusID (NCBI) 6832
Atlas_Id 47109
Location 10q22.1  [Link to chromosome band 10q22]
Location_base_pair Starts at 69180204 and ends at 69209098 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACTB (7p22.1) / SUPV3L1 (10q22.1)SUPV3L1 (10q22.1) / PRKG1 (10q11.23)SUPV3L1 (10q22.1) / VPS26A (10q22.1)
UBR1 (15q15.2) / SUPV3L1 (10q22.1)SUPV3L1 10q22.1 / VPS26A 10q22.1UBR1 15q15.2 / SUPV3L1 10q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;10)(q22;q22) SUPV3L1/VPS26A
t(10;15)(q22;q15) UBR1/SUPV3L1

External links

Nomenclature
HGNC (Hugo)SUPV3L1   11471
Cards
Entrez_Gene (NCBI)SUPV3L1  6832  Suv3 like RNA helicase
AliasesSUV3
GeneCards (Weizmann)SUPV3L1
Ensembl hg19 (Hinxton)ENSG00000156502 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156502 [Gene_View]  ENSG00000156502 [Sequence]  chr10:69180204-69209098 [Contig_View]  SUPV3L1 [Vega]
ICGC DataPortalENSG00000156502
TCGA cBioPortalSUPV3L1
AceView (NCBI)SUPV3L1
Genatlas (Paris)SUPV3L1
WikiGenes6832
SOURCE (Princeton)SUPV3L1
Genetics Home Reference (NIH)SUPV3L1
Genomic and cartography
GoldenPath hg38 (UCSC)SUPV3L1  -     chr10:69180204-69209098 +  10q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUPV3L1  -     10q22.1   [Description]    (hg19-Feb_2009)
EnsemblSUPV3L1 - 10q22.1 [CytoView hg19]  SUPV3L1 - 10q22.1 [CytoView hg38]
Mapping of homologs : NCBISUPV3L1 [Mapview hg19]  SUPV3L1 [Mapview hg38]
OMIM605122   
Gene and transcription
Genbank (Entrez)AF042169 AK290416 AK299670 BC036112 BM675613
RefSeq transcript (Entrez)NM_001301683 NM_001323584 NM_001323585 NM_001323586 NM_001323587 NM_001323588 NM_003171
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUPV3L1
Cluster EST : UnigeneHs.106469 [ NCBI ]
CGAP (NCI)Hs.106469
Alternative Splicing GalleryENSG00000156502
Gene ExpressionSUPV3L1 [ NCBI-GEO ]   SUPV3L1 [ EBI - ARRAY_EXPRESS ]   SUPV3L1 [ SEEK ]   SUPV3L1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUPV3L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6832
GTEX Portal (Tissue expression)SUPV3L1
Human Protein AtlasENSG00000156502-SUPV3L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IYB8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IYB8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IYB8
Splice isoforms : SwissVarQ8IYB8
Catalytic activity : Enzyme3.6.4.13 [ Enzyme-Expasy ]   3.6.4.133.6.4.13 [ IntEnz-EBI ]   3.6.4.13 [ BRENDA ]   3.6.4.13 [ KEGG ]   
PhosPhoSitePlusQ8IYB8
Domaine pattern : Prosite (Expaxy)HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)Helicase_C    P-loop_NTPase    SUV3_C   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    SUV3_C (PF12513)   
Domain families : Pfam (NCBI)pfam00271    pfam12513   
Domain families : Smart (EMBL)HELICc (SM00490)  
Conserved Domain (NCBI)SUPV3L1
DMDM Disease mutations6832
Blocks (Seattle)SUPV3L1
PDB (SRS)3RC3    3RC8   
PDB (PDBSum)3RC3    3RC8   
PDB (IMB)3RC3    3RC8   
PDB (RSDB)3RC3    3RC8   
Structural Biology KnowledgeBase3RC3    3RC8   
SCOP (Structural Classification of Proteins)3RC3    3RC8   
CATH (Classification of proteins structures)3RC3    3RC8   
SuperfamilyQ8IYB8
Human Protein Atlas [tissue]ENSG00000156502-SUPV3L1 [tissue]
Peptide AtlasQ8IYB8
HPRD05493
IPIIPI00412404   IPI00478485   
Protein Interaction databases
DIP (DOE-UCLA)Q8IYB8
IntAct (EBI)Q8IYB8
FunCoupENSG00000156502
BioGRIDSUPV3L1
STRING (EMBL)SUPV3L1
ZODIACSUPV3L1
Ontologies - Pathways
QuickGOQ8IYB8
Ontology : AmiGOmitochondrial mRNA catabolic process  positive regulation of mitochondrial RNA catabolic process  positive regulation of mitochondrial RNA catabolic process  mitochondrial RNA 3'-end processing  DNA binding  DNA helicase activity  RNA binding  double-stranded RNA binding  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial matrix  DNA recombination  RNA catabolic process  positive regulation of cell growth  DNA duplex unwinding  3'-5' RNA helicase activity  mitochondrial ncRNA surveillance  mitochondrial mRNA surveillance  mitochondrial nucleoid  protein homodimerization activity  negative regulation of apoptotic process  mitochondrial degradosome  mitochondrion morphogenesis  chromatin maintenance  mitochondrial RNA surveillance  
Ontology : EGO-EBImitochondrial mRNA catabolic process  positive regulation of mitochondrial RNA catabolic process  positive regulation of mitochondrial RNA catabolic process  mitochondrial RNA 3'-end processing  DNA binding  DNA helicase activity  RNA binding  double-stranded RNA binding  ATP-dependent RNA helicase activity  helicase activity  protein binding  ATP binding  nucleus  mitochondrion  mitochondrial matrix  DNA recombination  RNA catabolic process  positive regulation of cell growth  DNA duplex unwinding  3'-5' RNA helicase activity  mitochondrial ncRNA surveillance  mitochondrial mRNA surveillance  mitochondrial nucleoid  protein homodimerization activity  negative regulation of apoptotic process  mitochondrial degradosome  mitochondrion morphogenesis  chromatin maintenance  mitochondrial RNA surveillance  
NDEx NetworkSUPV3L1
Atlas of Cancer Signalling NetworkSUPV3L1
Wikipedia pathwaysSUPV3L1
Orthology - Evolution
OrthoDB6832
GeneTree (enSembl)ENSG00000156502
Phylogenetic Trees/Animal Genes : TreeFamSUPV3L1
HOVERGENQ8IYB8
HOGENOMQ8IYB8
Homologs : HomoloGeneSUPV3L1
Homology/Alignments : Family Browser (UCSC)SUPV3L1
Gene fusions - Rearrangements
Fusion : MitelmanSUPV3L1/VPS26A [10q22.1/10q22.1]  
Fusion : MitelmanUBR1/SUPV3L1 [15q15.2/10q22.1]  [t(10;15)(q22;q15)]  
Fusion PortalSUPV3L1 10q22.1 VPS26A 10q22.1 OV
Fusion PortalUBR1 15q15.2 SUPV3L1 10q22.1 BRCA
Fusion : QuiverSUPV3L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUPV3L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUPV3L1
dbVarSUPV3L1
ClinVarSUPV3L1
1000_GenomesSUPV3L1 
Exome Variant ServerSUPV3L1
ExAC (Exome Aggregation Consortium)ENSG00000156502
GNOMAD BrowserENSG00000156502
Genetic variants : HAPMAP6832
Genomic Variants (DGV)SUPV3L1 [DGVbeta]
DECIPHERSUPV3L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUPV3L1 
Mutations
ICGC Data PortalSUPV3L1 
TCGA Data PortalSUPV3L1 
Broad Tumor PortalSUPV3L1
OASIS PortalSUPV3L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUPV3L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUPV3L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch SUPV3L1
DgiDB (Drug Gene Interaction Database)SUPV3L1
DoCM (Curated mutations)SUPV3L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUPV3L1 (select a term)
intoGenSUPV3L1
Cancer3DSUPV3L1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605122   
Orphanet
DisGeNETSUPV3L1
MedgenSUPV3L1
Genetic Testing Registry SUPV3L1
NextProtQ8IYB8 [Medical]
TSGene6832
GENETestsSUPV3L1
Target ValidationSUPV3L1
Huge Navigator SUPV3L1 [HugePedia]
snp3D : Map Gene to Disease6832
BioCentury BCIQSUPV3L1
ClinGenSUPV3L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6832
Chemical/Pharm GKB GenePA36257
Clinical trialSUPV3L1
Miscellaneous
canSAR (ICR)SUPV3L1 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUPV3L1
EVEXSUPV3L1
GoPubMedSUPV3L1
iHOPSUPV3L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:52:38 CEST 2018
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