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SUV39H1 (suppressor of variegation 3-9 homolog 1)

Identity

Alias_namesSUV39H
suppressor of variegation 3-9 (Drosophila) homolog 1
suppressor of variegation 3-9 homolog 1 (Drosophila)
Alias_symbol (synonym)KMT1A
Other aliasH3-K9-HMTase 1
MG44
HGNC (Hugo) SUV39H1
LocusID (NCBI) 6839
Atlas_Id 43860
Location Xp11.23  [Link to chromosome band Xp11]
Location_base_pair Starts at 48553945 and ends at 48567406 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SUV39H1 (Xp11.23) / SUV39H1 (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)SUV39H1   11479
Cards
Entrez_Gene (NCBI)SUV39H1  6839  suppressor of variegation 3-9 homolog 1
AliasesH3-K9-HMTase; KMT1A; MG44; SUV39H
GeneCards (Weizmann)SUV39H1
Ensembl hg19 (Hinxton)ENSG00000101945 [Gene_View]  chrX:48553945-48567406 [Contig_View]  SUV39H1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000101945 [Gene_View]  chrX:48553945-48567406 [Contig_View]  SUV39H1 [Vega]
ICGC DataPortalENSG00000101945
TCGA cBioPortalSUV39H1
AceView (NCBI)SUV39H1
Genatlas (Paris)SUV39H1
WikiGenes6839
SOURCE (Princeton)SUV39H1
Genetics Home Reference (NIH)SUV39H1
Genomic and cartography
GoldenPath hg19 (UCSC)SUV39H1  -     chrX:48553945-48567406 +  Xp11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SUV39H1  -     Xp11.23   [Description]    (hg38-Dec_2013)
EnsemblSUV39H1 - Xp11.23 [CytoView hg19]  SUV39H1 - Xp11.23 [CytoView hg38]
Mapping of homologs : NCBISUV39H1 [Mapview hg19]  SUV39H1 [Mapview hg38]
OMIM300254   
Gene and transcription
Genbank (Entrez)AF019968 AF075109 AK223071 AK297566 AK298233
RefSeq transcript (Entrez)NM_001282166 NM_003173
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012530 NT_079573 NW_004929439
Consensus coding sequences : CCDS (NCBI)SUV39H1
Cluster EST : UnigeneHs.522639 [ NCBI ]
CGAP (NCI)Hs.522639
Alternative Splicing GalleryENSG00000101945
Gene ExpressionSUV39H1 [ NCBI-GEO ]   SUV39H1 [ EBI - ARRAY_EXPRESS ]   SUV39H1 [ SEEK ]   SUV39H1 [ MEM ]
Gene Expression Viewer (FireBrowse)SUV39H1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6839
GTEX Portal (Tissue expression)SUV39H1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43463   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43463  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43463
Splice isoforms : SwissVarO43463
Catalytic activity : Enzyme2.1.1.43 [ Enzyme-Expasy ]   2.1.1.432.1.1.43 [ IntEnz-EBI ]   2.1.1.43 [ BRENDA ]   2.1.1.43 [ KEGG ]   
PhosPhoSitePlusO43463
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)    POST_SET (PS50868)    PRE_SET (PS50867)    SAM_MT43_SUVAR39_3 (PS51579)    SET (PS50280)   
Domains : Interpro (EBI)Chromo/shadow_dom    Chromo_domain    Chromodomain-like    Chromodomain_CS    Histone_H3-K9_MeTrfase    Post-SET_dom    Pre-SET_dom    Pre-SET_Zn-bd_sub    SET_dom   
Domain families : Pfam (Sanger)Chromo (PF00385)    Pre-SET (PF05033)    SET (PF00856)   
Domain families : Pfam (NCBI)pfam00385    pfam05033    pfam00856   
Domain families : Smart (EMBL)CHROMO (SM00298)  PostSET (SM00508)  PreSET (SM00468)  SET (SM00317)  
Conserved Domain (NCBI)SUV39H1
DMDM Disease mutations6839
Blocks (Seattle)SUV39H1
PDB (SRS)3MTS   
PDB (PDBSum)3MTS   
PDB (IMB)3MTS   
PDB (RSDB)3MTS   
Structural Biology KnowledgeBase3MTS   
SCOP (Structural Classification of Proteins)3MTS   
CATH (Classification of proteins structures)3MTS   
SuperfamilyO43463
Human Protein AtlasENSG00000101945
Peptide AtlasO43463
HPRD02221
IPIIPI00941101   IPI00909418   IPI00156887   IPI00940259   IPI00844501   
Protein Interaction databases
DIP (DOE-UCLA)O43463
IntAct (EBI)O43463
FunCoupENSG00000101945
BioGRIDSUV39H1
STRING (EMBL)SUV39H1
ZODIACSUV39H1
Ontologies - Pathways
QuickGOO43463
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  chromatin silencing at rDNA  chromatin silencing at rDNA  chromosome, centromeric region  heterochromatin  condensed nuclear chromosome  transcription regulatory region sequence-specific DNA binding  chromatin binding  protein binding  nucleus  nuclear lamina  nucleoplasm  chromatin silencing complex  chromatin organization  transcription, DNA-templated  rRNA processing  cellular response to DNA damage stimulus  cell cycle  zinc ion binding  S-adenosylmethionine-dependent methyltransferase activity  viral process  histone-lysine N-methyltransferase activity  histone-lysine N-methyltransferase activity  cell differentiation  rDNA heterochromatin  histone H3-K9 dimethylation  histone H3-K9 trimethylation  histone methyltransferase activity  negative regulation of circadian rhythm  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K9 specific)  histone methyltransferase activity (H3-K9 specific)  protein N-terminus binding  rhythmic process  cellular response to hypoxia  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  chromatin silencing at rDNA  chromatin silencing at rDNA  chromosome, centromeric region  heterochromatin  condensed nuclear chromosome  transcription regulatory region sequence-specific DNA binding  chromatin binding  protein binding  nucleus  nuclear lamina  nucleoplasm  chromatin silencing complex  chromatin organization  transcription, DNA-templated  rRNA processing  cellular response to DNA damage stimulus  cell cycle  zinc ion binding  S-adenosylmethionine-dependent methyltransferase activity  viral process  histone-lysine N-methyltransferase activity  histone-lysine N-methyltransferase activity  cell differentiation  rDNA heterochromatin  histone H3-K9 dimethylation  histone H3-K9 trimethylation  histone methyltransferase activity  negative regulation of circadian rhythm  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K9 specific)  histone methyltransferase activity (H3-K9 specific)  protein N-terminus binding  rhythmic process  cellular response to hypoxia  
Pathways : KEGGLysine degradation   
NDEx NetworkSUV39H1
Atlas of Cancer Signalling NetworkSUV39H1
Wikipedia pathwaysSUV39H1
Orthology - Evolution
OrthoDB6839
GeneTree (enSembl)ENSG00000101945
Phylogenetic Trees/Animal Genes : TreeFamSUV39H1
HOVERGENO43463
HOGENOMO43463
Homologs : HomoloGeneSUV39H1
Homology/Alignments : Family Browser (UCSC)SUV39H1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUV39H1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUV39H1
dbVarSUV39H1
ClinVarSUV39H1
1000_GenomesSUV39H1 
Exome Variant ServerSUV39H1
ExAC (Exome Aggregation Consortium)SUV39H1 (select the gene name)
Genetic variants : HAPMAP6839
Genomic Variants (DGV)SUV39H1 [DGVbeta]
DECIPHER (Syndromes)X:48553945-48567406  ENSG00000101945
CONAN: Copy Number AnalysisSUV39H1 
Mutations
ICGC Data PortalSUV39H1 
TCGA Data PortalSUV39H1 
Broad Tumor PortalSUV39H1
OASIS PortalSUV39H1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUV39H1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSUV39H1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch SUV39H1
DgiDB (Drug Gene Interaction Database)SUV39H1
DoCM (Curated mutations)SUV39H1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUV39H1 (select a term)
intoGenSUV39H1
Cancer3DSUV39H1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300254   
Orphanet
MedgenSUV39H1
Genetic Testing Registry SUV39H1
NextProtO43463 [Medical]
TSGene6839
GENETestsSUV39H1
Huge Navigator SUV39H1 [HugePedia]
snp3D : Map Gene to Disease6839
BioCentury BCIQSUV39H1
ClinGenSUV39H1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6839
Chemical/Pharm GKB GenePA36264
Clinical trialSUV39H1
Miscellaneous
canSAR (ICR)SUV39H1 (select the gene name)
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUV39H1
EVEXSUV39H1
GoPubMedSUV39H1
iHOPSUV39H1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:29:58 CET 2017

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