SUV39H2 (suppressor of variegation 3-9 homolog 2)

2007-02-01  

Identity

HGNC
SUV39H2
LOCATION
10p13
LOCUSID
79723
ALIAS
KMT1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79723
MIM: 606503
HGNC: 17287
Ensembl: ENSG00000152455

Variants:

dbSNP: 79723
ClinVar: 79723
TCGA: ENSG00000152455
COSMIC: SUV39H2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152455ENST00000313519Q9H5I1
ENSG00000152455ENST00000354919Q9H5I1
ENSG00000152455ENST00000358298H0Y306
ENSG00000152455ENST00000378325Q9H5I1
ENSG00000152455ENST00000378331G5E9A8
ENSG00000152455ENST00000412254C9JMB4
ENSG00000152455ENST00000420416C9IYH9
ENSG00000152455ENST00000433779Q5JSS2

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Lysine degradationKEGGko00310
Lysine degradationKEGGhsa00310
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
PKMTs methylate histone lysinesREACTOMER-HSA-3214841

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182315862008Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.42
214027812011Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia.23
218969332011Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.19
261835272015SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells.18
167749422006Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.14
167749422006Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.14
238917372013Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.11
254597502015Activity and specificity of the human SUV39H2 protein lysine methyltransferase.7
294581432018SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.7
269889142016Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins.5

Citation

Dessen P

SUV39H2 (suppressor of variegation 3-9 homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45567/suv39h2