Atlas of Genetics and Cytogenetics in Oncology and Haematology

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SUV39H2 (suppressor of variegation 3-9 homolog 2)

Identity

Alias (NCBI)KMT1B
HGNC (Hugo) SUV39H2
HGNC Alias symbFLJ23414
KMT1B
HGNC Previous namesuppressor of variegation 3-9 homolog 2 (Drosophila)
LocusID (NCBI) 79723
Atlas_Id 45567
Location 10p13  [Link to chromosome band 10p13]
Location_base_pair Starts at 14878900 and ends at 14904305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SUV39H2 (10p13) / SUV39H2 (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)SUV39H2   17287
Cards
Entrez_Gene (NCBI)SUV39H2  79723  suppressor of variegation 3-9 homolog 2
AliasesKMT1B
GeneCards (Weizmann)SUV39H2
Ensembl hg19 (Hinxton)ENSG00000152455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152455 [Gene_View]  ENSG00000152455 [Sequence]  chr10:14878900-14904305 [Contig_View]  SUV39H2 [Vega]
ICGC DataPortalENSG00000152455
TCGA cBioPortalSUV39H2
AceView (NCBI)SUV39H2
Genatlas (Paris)SUV39H2
WikiGenes79723
SOURCE (Princeton)SUV39H2
Genetics Home Reference (NIH)SUV39H2
Genomic and cartography
GoldenPath hg38 (UCSC)SUV39H2  -     chr10:14878900-14904305 +  10p13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SUV39H2  -     10p13   [Description]    (hg19-Feb_2009)
GoldenPathSUV39H2 - 10p13 [CytoView hg19]  SUV39H2 - 10p13 [CytoView hg38]
ImmunoBaseENSG00000152455
genome Data Viewer NCBISUV39H2 [Mapview hg19]  
OMIM606503   
Gene and transcription
Genbank (Entrez)AK027067 AK222565 AK225369 AL834488 BC007754
RefSeq transcript (Entrez)NM_001193424 NM_001193425 NM_001193426 NM_001193427 NM_024670
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)SUV39H2
Alternative Splicing GalleryENSG00000152455
Gene ExpressionSUV39H2 [ NCBI-GEO ]   SUV39H2 [ EBI - ARRAY_EXPRESS ]   SUV39H2 [ SEEK ]   SUV39H2 [ MEM ]
Gene Expression Viewer (FireBrowse)SUV39H2 [ Firebrowse - Broad ]
GenevisibleExpression of SUV39H2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79723
GTEX Portal (Tissue expression)SUV39H2
Human Protein AtlasENSG00000152455-SUV39H2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H5I1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H5I1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H5I1
Splice isoforms : SwissVarQ9H5I1
Catalytic activity : Enzyme2.1.1.355 [ Enzyme-Expasy ]   2.1.1.3552.1.1.355 [ IntEnz-EBI ]   2.1.1.355 [ BRENDA ]   2.1.1.355 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9H5I1
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)    POST_SET (PS50868)    PRE_SET (PS50867)    SAM_MT43_SUVAR39_3 (PS51579)    SET (PS50280)   
Domains : Interpro (EBI)Chromo-like_dom_sf    Chromo/chromo_shadow_dom    Chromo_domain    Chromodomain_CS    Histone_H3-K9_MeTrfase    Post-SET_dom    Pre-SET_dom    SET_dom   
Domain families : Pfam (Sanger)Chromo (PF00385)    Pre-SET (PF05033)    SET (PF00856)   
Domain families : Pfam (NCBI)pfam00385    pfam05033    pfam00856   
Domain families : Smart (EMBL)CHROMO (SM00298)  PostSET (SM00508)  PreSET (SM00468)  SET (SM00317)  
Conserved Domain (NCBI)SUV39H2
DMDM Disease mutations79723
Blocks (Seattle)SUV39H2
PDB (RSDB)2R3A    6P0R   
PDB Europe2R3A    6P0R   
PDB (PDBSum)2R3A    6P0R   
PDB (IMB)2R3A    6P0R   
Structural Biology KnowledgeBase2R3A    6P0R   
SCOP (Structural Classification of Proteins)2R3A    6P0R   
CATH (Classification of proteins structures)2R3A    6P0R   
SuperfamilyQ9H5I1
Human Protein Atlas [tissue]ENSG00000152455-SUV39H2 [tissue]
Peptide AtlasQ9H5I1
HPRD07580
IPIIPI00002929   IPI00218860   IPI00218861   IPI00640095   IPI00552780   IPI00640544   IPI00641091   IPI01025501   
Protein Interaction databases
DIP (DOE-UCLA)Q9H5I1
IntAct (EBI)Q9H5I1
FunCoupENSG00000152455
BioGRIDSUV39H2
STRING (EMBL)SUV39H2
ZODIACSUV39H2
Ontologies - Pathways
QuickGOQ9H5I1
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  chromosome, centromeric region  chromatin  transcription regulatory region sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  chromatin assembly or disassembly  chromatin remodeling  cell cycle  zinc ion binding  cell differentiation  histone lysine methylation  histone H3-K9 dimethylation  histone H3-K9 trimethylation  negative regulation of circadian rhythm  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K9 specific)  histone methyltransferase activity (H3-K9 specific)  rhythmic process  cellular response to hypoxia  S-adenosyl-L-methionine binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  chromosome, centromeric region  chromatin  transcription regulatory region sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  chromatin assembly or disassembly  chromatin remodeling  cell cycle  zinc ion binding  cell differentiation  histone lysine methylation  histone H3-K9 dimethylation  histone H3-K9 trimethylation  negative regulation of circadian rhythm  negative regulation of transcription, DNA-templated  histone methyltransferase activity (H3-K9 specific)  histone methyltransferase activity (H3-K9 specific)  rhythmic process  cellular response to hypoxia  S-adenosyl-L-methionine binding  
Pathways : KEGGLysine degradation   
NDEx NetworkSUV39H2
Atlas of Cancer Signalling NetworkSUV39H2
Wikipedia pathwaysSUV39H2
Orthology - Evolution
OrthoDB79723
GeneTree (enSembl)ENSG00000152455
Phylogenetic Trees/Animal Genes : TreeFamSUV39H2
HOGENOMQ9H5I1
Homologs : HomoloGeneSUV39H2
Homology/Alignments : Family Browser (UCSC)SUV39H2
Gene fusions - Rearrangements
Fusion : QuiverSUV39H2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSUV39H2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SUV39H2
dbVarSUV39H2
ClinVarSUV39H2
1000_GenomesSUV39H2 
Exome Variant ServerSUV39H2
GNOMAD BrowserENSG00000152455
Varsome BrowserSUV39H2
Genetic variants : HAPMAP79723
Genomic Variants (DGV)SUV39H2 [DGVbeta]
DECIPHERSUV39H2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSUV39H2 
Mutations
ICGC Data PortalSUV39H2 
TCGA Data PortalSUV39H2 
Broad Tumor PortalSUV39H2
OASIS PortalSUV39H2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSUV39H2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSUV39H2
Mutations and Diseases : HGMDSUV39H2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SUV39H2
DgiDB (Drug Gene Interaction Database)SUV39H2
DoCM (Curated mutations)SUV39H2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SUV39H2 (select a term)
intoGenSUV39H2
Cancer3DSUV39H2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606503   
Orphanet
DisGeNETSUV39H2
MedgenSUV39H2
Genetic Testing Registry SUV39H2
NextProtQ9H5I1 [Medical]
TSGene79723
GENETestsSUV39H2
Target ValidationSUV39H2
Huge Navigator SUV39H2 [HugePedia]
snp3D : Map Gene to Disease79723
BioCentury BCIQSUV39H2
ClinGenSUV39H2
Clinical trials, drugs, therapy
Protein Interactions : CTD79723
Pharm GKB GenePA134868807
Clinical trialSUV39H2
Miscellaneous
canSAR (ICR)SUV39H2 (select the gene name)
HarmonizomeSUV39H2
DataMed IndexSUV39H2
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSUV39H2
EVEXSUV39H2
GoPubMedSUV39H2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:38:19 CEST 2020
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