SV2A (synaptic vesicle glycoprotein 2A)

2010-06-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
SV2
FUSION GENES

Other Information

Locus ID:

NCBI: 9900
MIM: 185860
HGNC: 20566
Ensembl: ENSG00000159164

Variants:

dbSNP: 9900
ClinVar: 9900
TCGA: ENSG00000159164
COSMIC: SV2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159164ENST00000369145Q7L0J3
ENSG00000159164ENST00000369146Q7L0J3

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
ECM-receptor interactionKEGGko04512
ECM-receptor interactionKEGGhsa04512
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Neurotoxicity of clostridium toxinsREACTOMER-HSA-168799
Toxicity of botulinum toxin type A (BoNT/A)REACTOMER-HSA-5250968
Toxicity of botulinum toxin type E (BoNT/E)REACTOMER-HSA-5250992
Toxicity of botulinum toxin type D (BoNT/D)REACTOMER-HSA-5250955
Toxicity of botulinum toxin type F (BoNT/F)REACTOMER-HSA-5250981

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
236178382014Expression pattern of synaptic vesicle protein 2 (SV2) isoforms in patients with temporal lobe epilepsy and hippocampal sclerosis.18
185247682008Synaptic vesicle protein 2 binds adenine nucleotides.14
193997872009Botulinum toxin type A inhibits the growth of LNCaP human prostate cancer cells in vitro and in vivo.12
192204102009Expression patterns of synaptic vesicle protein 2A in focal cortical dysplasia and TSC-cortical tubers.11
217956552011Synaptic vesicle protein 2A predicts response to levetiracetam in patients with glioma.11
201678142010Expression of synaptic vesicle protein 2A in epilepsy-associated brain tumors and in the peritumoral cortex.10
242844122014Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.10
253263862014The human synaptic vesicle protein, SV2A, functions as a galactose transporter in Saccharomyces cerevisiae.8
219368122011Combining modelling and mutagenesis studies of synaptic vesicle protein 2A to identify a series of residues involved in racetam binding.6
230178262012Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.5

Citation

Dessen P

SV2A (synaptic vesicle glycoprotein 2A)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51509/sv2a