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SV2B (synaptic vesicle glycoprotein 2B)

Identity

Alias (NCBI)HsT19680
HGNC (Hugo) SV2B
HGNC Alias symbKIAA0735
HsT19680
LocusID (NCBI) 9899
Atlas_Id 54677
Location 15q26.1  [Link to chromosome band 15q26]
Location_base_pair Starts at 91100257 and ends at 91302565 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GABBR1 (6p22.1) / SV2B (15q26.1)RUNX1 (21q22.12) / SV2B (15q26.1)ZSCAN23 (6p22.1) / SV2B (15q26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(15;21)(q26;q22) RUNX1/SV2B


External links

 

Nomenclature
HGNC (Hugo)SV2B   16874
Cards
Entrez_Gene (NCBI)SV2B    synaptic vesicle glycoprotein 2B
AliasesHsT19680
GeneCards (Weizmann)SV2B
Ensembl hg19 (Hinxton)ENSG00000185518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185518 [Gene_View]  ENSG00000185518 [Sequence]  chr15:91100257-91302565 [Contig_View]  SV2B [Vega]
ICGC DataPortalENSG00000185518
TCGA cBioPortalSV2B
AceView (NCBI)SV2B
Genatlas (Paris)SV2B
SOURCE (Princeton)SV2B
Genetics Home Reference (NIH)SV2B
Genomic and cartography
GoldenPath hg38 (UCSC)SV2B  -     chr15:91100257-91302565 +  15q26.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)SV2B  -     15q26.1   [Description]    (hg19-Feb_2009)
GoldenPathSV2B - 15q26.1 [CytoView hg19]  SV2B - 15q26.1 [CytoView hg38]
ImmunoBaseENSG00000185518
Genome Data Viewer NCBISV2B [Mapview hg19]  
OMIM185861   
Gene and transcription
Genbank (Entrez)AB018278 AF052188 AK124722 AK294902 AL109781
RefSeq transcript (Entrez)NM_001167580 NM_001323031 NM_001323032 NM_001323033 NM_001323034 NM_001323036 NM_001323037 NM_001323038 NM_001323039 NM_001323040 NM_014848
Consensus coding sequences : CCDS (NCBI)SV2B
Gene ExpressionSV2B [ NCBI-GEO ]   SV2B [ EBI - ARRAY_EXPRESS ]   SV2B [ SEEK ]   SV2B [ MEM ]
Gene Expression Viewer (FireBrowse)SV2B [ Firebrowse - Broad ]
GenevisibleExpression of SV2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9899
GTEX Portal (Tissue expression)SV2B
Human Protein AtlasENSG00000185518-SV2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7L1I2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7L1I2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7L1I2
PhosPhoSitePlusQ7L1I2
Domaine pattern : Prosite (Expaxy)MFS (PS50850)   
Domains : Interpro (EBI)MFS    MFS_dom    MFS_sugar_transport-like    MFS_trans_sf    Sugar_transporter_CS    SV2   
Domain families : Pfam (Sanger)MFS_1 (PF07690)    Sugar_tr (PF00083)   
Domain families : Pfam (NCBI)pfam07690    pfam00083   
Conserved Domain (NCBI)SV2B
SuperfamilyQ7L1I2
AlphaFold pdb e-kbQ7L1I2   
Human Protein Atlas [tissue]ENSG00000185518-SV2B [tissue]
HPRD11765
Protein Interaction databases
DIP (DOE-UCLA)Q7L1I2
IntAct (EBI)Q7L1I2
BioGRIDSV2B
STRING (EMBL)SV2B
ZODIACSV2B
Ontologies - Pathways
QuickGOQ7L1I2
Ontology : AmiGOacrosomal vesicle  protein binding  plasma membrane  neurotransmitter transport  chemical synaptic transmission  synaptic vesicle  synaptic vesicle  membrane  integral component of membrane  transmembrane transporter activity  synaptic vesicle membrane  synaptic vesicle membrane  neuron projection  transmembrane transport  
Ontology : EGO-EBIacrosomal vesicle  protein binding  plasma membrane  neurotransmitter transport  chemical synaptic transmission  synaptic vesicle  synaptic vesicle  membrane  integral component of membrane  transmembrane transporter activity  synaptic vesicle membrane  synaptic vesicle membrane  neuron projection  transmembrane transport  
Pathways : KEGGECM-receptor interaction   
NDEx NetworkSV2B
Atlas of Cancer Signalling NetworkSV2B
Wikipedia pathwaysSV2B
Orthology - Evolution
OrthoDB9899
GeneTree (enSembl)ENSG00000185518
Phylogenetic Trees/Animal Genes : TreeFamSV2B
Homologs : HomoloGeneSV2B
Homology/Alignments : Family Browser (UCSC)SV2B
Gene fusions - Rearrangements
Fusion : MitelmanRUNX1/SV2B [21q22.12/15q26.1]  
Fusion : QuiverSV2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSV2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SV2B
dbVarSV2B
ClinVarSV2B
MonarchSV2B
1000_GenomesSV2B 
Exome Variant ServerSV2B
GNOMAD BrowserENSG00000185518
Varsome BrowserSV2B
ACMGSV2B variants
VarityQ7L1I2
Genomic Variants (DGV)SV2B [DGVbeta]
DECIPHERSV2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisSV2B 
Mutations
ICGC Data PortalSV2B 
TCGA Data PortalSV2B 
Broad Tumor PortalSV2B
OASIS PortalSV2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICSV2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DSV2B
Mutations and Diseases : HGMDSV2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaSV2B
DgiDB (Drug Gene Interaction Database)SV2B
DoCM (Curated mutations)SV2B
CIViC (Clinical Interpretations of Variants in Cancer)SV2B
Cancer3DSV2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM185861   
Orphanet
DisGeNETSV2B
MedgenSV2B
Genetic Testing Registry SV2B
NextProtQ7L1I2 [Medical]
GENETestsSV2B
Target ValidationSV2B
Huge Navigator SV2B [HugePedia]
ClinGenSV2B
Clinical trials, drugs, therapy
MyCancerGenomeSV2B
Protein Interactions : CTDSV2B
Pharm GKB GenePA134930999
PharosQ7L1I2
Clinical trialSV2B
Miscellaneous
canSAR (ICR)SV2B
HarmonizomeSV2B
DataMed IndexSV2B
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXSV2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:33:56 CEST 2021

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